دورية أكاديمية
أعرض في EDS

Clinical, Morphologic, and Molecular Features of MAP3K8 Rearranged Spitz Neoplasms: A Retrospective Study Documenting That Bonafide Spitz Melanomas Are Rare.

التفاصيل البيبلوغرافية
العنوان: Clinical, Morphologic, and Molecular Features of MAP3K8 Rearranged Spitz Neoplasms: A Retrospective Study Documenting That Bonafide Spitz Melanomas Are Rare.
المؤلفون: Patel P; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL., Hagstrom M, Sharma N, Chen A, Dhillon S, Fumero-Velázquez M, Olivares S, Gerami P
المصدر: The American journal of surgical pathology [Am J Surg Pathol] 2024 Apr 01; Vol. 48 (4), pp. 437-446. Date of Electronic Publication: 2024 Jan 19.
نوع المنشور: Meta-Analysis; Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 7707904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-0979 (Electronic) Linking ISSN: 01475185 NLM ISO Abbreviation: Am J Surg Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2015- > : Philadelphia, PA : Wolters Kluwer Health, Inc.
Original Publication: New York, Masson.
مواضيع طبية MeSH: Melanoma*/pathology , Nevus, Epithelioid and Spindle Cell*/genetics , Skin Neoplasms*/pathology, Humans ; Retrospective Studies ; Mutation ; Proto-Oncogene Proteins/genetics ; MAP Kinase Kinase Kinases/genetics
مستخلص: Previous studies regarding the clinical behavior of Spitz neoplasms lack genomic characterization. We aim to assess our hypothesis that most MAP3K8 Spitz neoplasms are indolent despite MAP3K8 being the single most common driver of Spitz melanoma. Further, we aim to identify genomic features associated with aggressive behavior and to better characterize the morphology of these cases. We analyzed the outcomes of MAP3K8 Spitz neoplasms. We also performed a meta-analysis of the outcomes of MAP3K8 Spitz from the literature. Morphologic features were compared with other variants of Spitz using a Student t test and χ 2 test. Two of 35 cases resulted in local recurrence and one of these cases had local regional metastasis; all other cases had no evidence of recurrence (mean follow-up time: 33 mo). MAP3K8 Spitz only rarely results in aggressive behavior. Metastatic cases have genomic mutations associated with tumor progression. Morphologically, MAP3K8 Spitz neoplasms frequently showed nodular silhouette, large cell size, epithelioid morphology, and severe nuclear atypia resulting in more frequent diagnosis as Spitz melanoma. Most MAP3K8 Spitz neoplasms have excellent prognoses, apart from rare cases harboring additional genomic abnormalities associated with tumor progression.
Competing Interests: Conflicts of Interest and Source of Funding: This work was supported by the IDP Foundation. P.G. has served as a consultant for Castle Biosciences and has received an honorarium for this, he has also received royalties for textbooks from Elsevier. For the remaining authors, none were declared.
(Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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المشرفين على المادة: EC 2.7.11.25 (MAP3K8 protein, human)
0 (Proto-Oncogene Proteins)
EC 2.7.11.25 (MAP Kinase Kinase Kinases)
تواريخ الأحداث: Date Created: 20240117 Date Completed: 20240315 Latest Revision: 20240315
رمز التحديث: 20240315
DOI: 10.1097/PAS.0000000000002179
PMID: 38233731
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-0979
DOI:10.1097/PAS.0000000000002179