دورية أكاديمية
In Vitro Antiviral Activity of a New Indol-3-carboxylic Acid Derivative Against SARS-CoV-2.
| العنوان: | In Vitro Antiviral Activity of a New Indol-3-carboxylic Acid Derivative Against SARS-CoV-2. |
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| المؤلفون: | Narovlyansky AN; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Filimonova MV; National Medical Research Center for Radiology, Ministry of Health of the Russian Federation, Obninsk, 249036 Russian Federation., Tsyshkova NG; National Medical Research Center for Radiology, Ministry of Health of the Russian Federation, Obninsk, 249036 Russian Federation., Pronin AV; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Grebennikova TV; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Karamov EV; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Larichev VF; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Kornilayeva GV; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Fedyakina IT; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Dolzhikova IV; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Mezentseva MV; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Isaeva EI; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Poloskov VV; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Koval LS; National Medical Research Center for Radiology, Ministry of Health of the Russian Federation, Obninsk, 249036 Russian Federation., Marinchenko VP; National Medical Research Center for Radiology, Ministry of Health of the Russian Federation, Obninsk, 249036 Russian Federation., Surinova VI; National Medical Research Center for Radiology, Ministry of Health of the Russian Federation, Obninsk, 249036 Russian Federation., Filimonov AS; National Medical Research Center for Radiology, Ministry of Health of the Russian Federation, Obninsk, 249036 Russian Federation., Shitova AA; National Medical Research Center for Radiology, Ministry of Health of the Russian Federation, Obninsk, 249036 Russian Federation., Soldatova OV; National Medical Research Center for Radiology, Ministry of Health of the Russian Federation, Obninsk, 249036 Russian Federation., Sanin AV; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Zubashev IK; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Ponomarev AV; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Veselovsky VV; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991 Russian Federation., Kozlov VV; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Stepanov AV; N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991 Russian Federation., Khomich AV; Gamasintez LLC, Moscow, 123098 Russian Federation., Kozlov VS; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Ivanov SA; National Medical Research Center for Radiology, Ministry of Health of the Russian Federation, Obninsk, 249036 Russian Federation., Shegai PV; National Medical Research Center for Radiology, Ministry of Health of the Russian Federation, Obninsk, 249036 Russian Federation., Kaprin AD; National Medical Research Center for Radiology, Ministry of Health of the Russian Federation, Obninsk, 249036 Russian Federation., Ershov FI; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation., Gintsburg AL; National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya, Ministry of Health of the Russian Federation, Moscow, 123098 Russian Federation. |
| المصدر: | Acta naturae [Acta Naturae] 2023 Oct-Dec; Vol. 15 (4), pp. 83-91. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Research University Higher School of Economics Country of Publication: Russia (Federation) NLM ID: 101525823 Publication Model: Print Cited Medium: Print ISSN: 2075-8251 (Print) Linking ISSN: 20758251 NLM ISO Abbreviation: Acta Naturae Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2019- : [Moscow] : National Research University Higher School of Economics Original Publication: Moscow : Park Media Ltd |
| مستخلص: | The coronavirus disease (COVID-19) pandemic has brought into sharp relief the threat posed by coronaviruses and laid the foundation for a fundamental analysis of this viral family, as well as a search for effective anti-COVID drugs. Work is underway to update existent vaccines against COVID-19, and screening for low-molecular-weight anti-COVID drug candidates for outpatient medicine continues. The opportunities and ways to accelerate the development of antiviral drugs against other pathogens are being discussed in the context of preparing for the next pandemic. In 2012-2015, Tsyshkova et al. synthesized a group of water-soluble low-molecular-weight compounds exhibiting an antiviral activity, whose chemical structure was similar to that of arbidol. Among those, there were a number of water-soluble compounds based on 5-methoxyindole-3-carboxylic acid aminoalkyl esters. Only one member of this rather extensive group of compounds, dihydrochloride of 6-bromo-5-methoxy-1-methyl-2-(1-piperidinomethyl)-3-(2-diethylaminoethoxy) carbonylindole, exhibited a reliable antiviral effect against SARS-CoV-2 in vitro . At a concentration of 52.0 μM, this compound completely inhibited the replication of the SARS-CoV-2 virus with an infectious activity of 106 TCID50/mL. The concentration curves of the analyzed compound indicate the specificity of its action. Interferon-inducing activity, as well as suppression of syncytium formation induced by the spike protein (S-glycoprotein) of SARS-CoV-2 by 89%, were also revealed. In view of its synthetic accessibility - high activity (IC (Copyright ® 2023 National Research University Higher School of Economics.) |
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| فهرسة مساهمة: | Keywords: SARS-CoV-2; antiviral activity; cell culture; indole-3 carboxylic acid derivative |
| تواريخ الأحداث: | Date Created: 20240118 Latest Revision: 20240119 |
| رمز التحديث: | 20240119 |
| مُعرف محوري في PubMed: | PMC10790354 |
| DOI: | 10.32607/actanaturae.26623 |
| PMID: | 38234608 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2075-8251 |
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| DOI: | 10.32607/actanaturae.26623 |