دورية أكاديمية
أعرض في EDS

Cracking the Code: The Role of Peripheral Nervous System Signaling in Fracture Repair.

التفاصيل البيبلوغرافية
العنوان: Cracking the Code: The Role of Peripheral Nervous System Signaling in Fracture Repair.
المؤلفون: Morris AJ; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA., Parker RS; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA., Nazzal MK; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA., Natoli RM; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA., Fehrenbacher JC; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA.; Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA., Kacena MA; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. mkacena@iupui.edu.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA. mkacena@iupui.edu.; Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA. mkacena@iupui.edu., White FA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA. fawhite@iu.edu.; Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA. fawhite@iu.edu.; Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA. fawhite@iu.edu.; Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN, USA. fawhite@iu.edu.
المصدر: Current osteoporosis reports [Curr Osteoporos Rep] 2024 Feb; Vol. 22 (1), pp. 193-204. Date of Electronic Publication: 2024 Jan 18.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Current Science Country of Publication: United States NLM ID: 101176492 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1544-2241 (Electronic) Linking ISSN: 15441873 NLM ISO Abbreviation: Curr Osteoporos Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : Current Science, c2003-
مواضيع طبية MeSH: Artificial Intelligence* , Fractures, Bone*, Humans ; Osteogenesis ; Fracture Healing/physiology ; Peripheral Nervous System ; Inflammation
مستخلص: Purpose of Review: The traditionally understated role of neural regulation in fracture healing is gaining prominence, as recent findings underscore the peripheral nervous system's critical contribution to bone repair. Indeed, it is becoming more evident that the nervous system modulates every stage of fracture healing, from the onset of inflammation to repair and eventual remodeling.
Recent Findings: Essential to this process are neurotrophins and neuropeptides, such as substance P, calcitonin gene-related peptide, and neuropeptide Y. These molecules fulfill key roles in promoting osteogenesis, influencing inflammation, and mediating pain. The sympathetic nervous system also plays an important role in the healing process: while local sympathectomies may improve fracture healing, systemic sympathetic denervation impairs fracture healing. Furthermore, chronic activation of the sympathetic nervous system, often triggered by stress, is a potential impediment to effective fracture healing, marking an important area for further investigation. The potential to manipulate aspects of the nervous system offers promising therapeutic possibilities for improving outcomes in fracture healing. This review article is part of a series of multiple manuscripts designed to determine the utility of using artificial intelligence for writing scientific reviews.
(© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
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معلومات مُعتمدة: R01 AG060621 United States AG NIA NIH HHS; R01 NS102415 United States NS NINDS NIH HHS; UL1 TR002529 United States TR NCATS NIH HHS; HL110854 United States NH NIH HHS; I01 RX003552 United States RX RRD VA; AG060621 United States NH NIH HHS; I01 BX003751 United States BX BLRD VA; IK6 RX004809 United States RX RRD VA; AR065971 United States NH NIH HHS; HL110854 United States NH NIH HHS; AR065971 United States NH NIH HHS; AG060621 United States NH NIH HHS
فهرسة مساهمة: Keywords: AI; Artificial intelligence; ChatGPT; Fracture healing; Neural regulation; Neuropeptides; Neurotrophins; Sympathetic nervous system
تواريخ الأحداث: Date Created: 20240118 Date Completed: 20240305 Latest Revision: 20240604
رمز التحديث: 20240605
مُعرف محوري في PubMed: PMC10912155
DOI: 10.1007/s11914-023-00846-y
PMID: 38236511
قاعدة البيانات: MEDLINE
الوصف
تدمد:1544-2241
DOI:10.1007/s11914-023-00846-y