التفاصيل البيبلوغرافية
| العنوان: |
DNA Methylation and Counterdirectional Pigmentation Change following Immune Challenge in a Small Ectotherm. |
| المؤلفون: |
Tevs DR, Mukhalian JA, Simpson E, Cox CL, Schrey AW, McBrayer LD |
| المصدر: |
Physiological and biochemical zoology : PBZ [Physiol Biochem Zool] 2023 Nov-Dec; Vol. 96 (6), pp. 418-429. Date of Electronic Publication: 2023 Oct 19. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: University of Chicago Press Country of Publication: United States NLM ID: 100883369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-5293 (Electronic) Linking ISSN: 15222152 NLM ISO Abbreviation: Physiol Biochem Zool Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Chicago, IL : University of Chicago Press, c1999-2023. |
| مواضيع طبية MeSH: |
DNA Methylation* , Hypothermia*, Animals ; Pigmentation ; Ecosystem |
| مستخلص: |
AbstractBy allowing for increased absorption or reflectance of solar radiation, changes in pigmentation may assist ectotherms in responding to immune challenges by enabling a more precise regulation of behavioral fever or hypothermia. Variation in epigenetic characteristics may also assist in regulating immune-induced pigmentation changes and managing the body's energetic reserves following infection. Here, we explore how dorsal pigmentation, metabolic rate, and DNA methylation in the Florida scrub lizard ( Sceloporus woodi ) respond to two levels of immune challenge across two habitat types. We found changes in pigmentation that are suggestive of efforts to assist in behavioral fever and hypothermia depending on the intensity of immune challenge. We also found correlations between DNA methylation in liver tissue and pigmentation change along the dorsum, indicating that color transitions may be part of a multifaceted immune response across tissue types. The relationship between immune response and metabolic rate supports the idea that energetic reserves may be conserved for the costs associated with behavioral fever when immune challenge is low and the immune functions when immune challenge is high. While immune response appeared to be unaffected by habitat type, we found differences in metabolic activity between habitats, suggesting differences in the energetic costs associated with each. To our knowledge, these results present the first potential evidence of pigmentation change in ectotherms in association with immune response. The relationship between immune response, DNA methylation, and pigmentation change also highlights the importance of epigenetic mechanisms in organism physiology. |
| فهرسة مساهمة: |
Keywords: DNA methylation; Florida scrub; epiRADseq; immune challenge; pigmentation change |
| تواريخ الأحداث: |
Date Created: 20240118 Date Completed: 20240122 Latest Revision: 20240122 |
| رمز التحديث: |
20240122 |
| DOI: |
10.1086/727692 |
| PMID: |
38237192 |
| قاعدة البيانات: |
MEDLINE |
