دورية أكاديمية
Infant lung function and early skin barrier impairment in the development of asthma at age 3 years.
| العنوان: | Infant lung function and early skin barrier impairment in the development of asthma at age 3 years. |
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| المؤلفون: | Färdig M; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden., Hoyer A; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden., Almqvist C; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Bains KES; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway., Carlsen KCL; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway., Gudmundsdóttir HK; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway., Granum B; Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway., Haugen GN; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, Norway., Hedlin G; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden., Jonassen CM; Department of Virology, Norwegian Institute of Public Health, Oslo, Norway.; Genetic Unit, Centre for Laboratory Medicine, Østfold Hospital Trust, Kalnes, Norway., Konradsen JR; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden., Lie A; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway., Rehbinder EM; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Dermatology and Vaenerology, Oslo University Hospital, Oslo, Norway., Skjerven HO; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway., Staff AC; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, Norway., Vettukattil R; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway., Söderhäll C; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden., Nordlund B; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. |
| المصدر: | Allergy [Allergy] 2024 Mar; Vol. 79 (3), pp. 667-678. Date of Electronic Publication: 2024 Jan 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 7804028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1398-9995 (Electronic) Linking ISSN: 01054538 NLM ISO Abbreviation: Allergy Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Copenhagen : Wiley-Blackwell Original Publication: Copenhagen, Munksgaard. |
| مواضيع طبية MeSH: | Eczema*/epidemiology , Eczema*/genetics , Asthma*/epidemiology , Asthma*/genetics , Asthma*/complications , Dermatitis, Atopic*/diagnosis, Child ; Infant ; Male ; Female ; Humans ; Child, Preschool ; Genotype ; Mutation ; Lung ; Intermediate Filament Proteins/genetics |
| مستخلص: | Background: Largely unexplored, we investigated if lower lung function, impaired skin barrier function by transepidermal water loss (TEWL), eczema, and filaggrin (FLG) mutations in infancy were associated with asthma in early childhood. Methods: From the factorially designed randomized controlled intervention study PreventADALL, we evaluated 1337/2394 children from all randomization groups with information on asthma at age 3 years, and at age 3 months either lung function, TEWL, eczema, and/or FLG mutations. Lower lung function was defined as the time to peak tidal expiratory flow to expiratory time (t Results: Lower lung function and skin barrier impairment were associated with asthma in general; aOR (95% CI) 5.4 (2.1, 13.7) and 1.6 (1.1, 2.5), while eczema and FLG mutations were associated with asthma in children with atopic dermatitis or allergic sensitization only. Stratifying for sex, the risk of asthma was only increased in boys with lower lung function; aOR (95% CI) 7.7 (2.5, 23.6), and in girls with FLG mutations; aOR (95% CI) 3.5 (1.5, 8.2). Conclusion: Lower lung function and impaired skin barrier function in infancy may increase the risk of asthma at age 3 years. (© 2024 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | The Norwegian Research Council; South-Eastern Norway Regional Health Authority; The University of Oslo; Oslo University Hospital; The Foundation for Healthcare and Allergy Research in Sweden -Vårdalstiftelsen; Health and Rehabilitation Norway; Fürst Medical Laboratory, Oslo, Norway; Thermo Fisher Scientific, Uppsala, Sweden; Arne Ingel's legat; Norwegian Society of Dermatology and Venerology; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Region Stockholm; The Sven Jerring Foundation; Swedish Order of Freemasons Foundation Barnhuset; The Swedish Research Council - the Initiative for Clinical Therapy Research; SFO-V Karolinska Institutet; The Swedish Heart-Lung Foundation; Sykehuset Østfold; The Kloster foundation; The Norwegian Association of Asthma and Allergy; Barnestiftelsen at Oslo University Hospital; The Samaritan Foundation for Pediatric Research; The Frithjof Nansen Institute; Roche; The Magnus Bergwall foundation; The Hesselman Foundation; The Swedish Society of Medicine; The Konsul Th C Bergh's Foundation; KI grants; The King Gustaf V 80th Birthday Foundation; The Pediatric Research Foundation at Astrid Lindgren Children's Hospital; The Cancer- and Allergy Foundation; The Swedish Asthma and Allergy Association's Research Foundation |
| فهرسة مساهمة: | Keywords: PreventADALL; asthma; infants; lung function; skin barrier function |
| المشرفين على المادة: | 0 (Intermediate Filament Proteins) |
| تواريخ الأحداث: | Date Created: 20240119 Date Completed: 20240301 Latest Revision: 20240710 |
| رمز التحديث: | 20240710 |
| DOI: | 10.1111/all.16024 |
| PMID: | 38239099 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1398-9995 |
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| DOI: | 10.1111/all.16024 |