Supplementation of red palm olein-enriched biscuits improves levels of provitamin A carotenes, iron, and erythropoiesis in vitamin A-deficient primary schoolchildren: a double-blinded randomised controlled trial.

التفاصيل البيبلوغرافية
العنوان:	Supplementation of red palm olein-enriched biscuits improves levels of provitamin A carotenes, iron, and erythropoiesis in vitamin A-deficient primary schoolchildren: a double-blinded randomised controlled trial.
المؤلفون:	Tan PY; Nutrition Unit, Division of Product Development and Advisory Services, Malaysian Palm Oil Board, No. 6, Persiaran Institusi, Bandar Baru Bangi, 43000, Kajang, Selangor, Malaysia.; Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia., Loganathan R; Nutrition Unit, Division of Product Development and Advisory Services, Malaysian Palm Oil Board, No. 6, Persiaran Institusi, Bandar Baru Bangi, 43000, Kajang, Selangor, Malaysia. radhika@mpob.gov.my., Teng KT; Nutrition Unit, Division of Product Development and Advisory Services, Malaysian Palm Oil Board, No. 6, Persiaran Institusi, Bandar Baru Bangi, 43000, Kajang, Selangor, Malaysia., Mohd Johari SN; Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia., Lee SC; Type 2 Immunity Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA., Selvaduray KR; Nutrition Unit, Division of Product Development and Advisory Services, Malaysian Palm Oil Board, No. 6, Persiaran Institusi, Bandar Baru Bangi, 43000, Kajang, Selangor, Malaysia., Ngui R; Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.; Department of Paraclinical Sciences, Faculty of Medicine & Health Sciences, Universiti Malaysia Sarawak, 94300, Kota Samarahan, Sarawak, Malaysia., Lim YA; Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. limailian@um.edu.my.
المصدر:	European journal of nutrition [Eur J Nutr] 2024 Apr; Vol. 63 (3), pp. 905-918. Date of Electronic Publication: 2024 Jan 19.
نوع المنشور:	Randomized Controlled Trial; Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Steinkopff Country of Publication: Germany NLM ID: 100888704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1436-6215 (Electronic) Linking ISSN: 14366207 NLM ISO Abbreviation: Eur J Nutr Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Darmstadt, Germany : Steinkopff, 1999-
مواضيع طبية MeSH:	Vitamin A* , Vitamin A Deficiency/drug therapy , Vitamin A Deficiency/epidemiology, Child ; Humans ; Carotenoids ; Provitamins ; Iron ; Erythropoiesis ; Dietary Supplements ; Nutritional Status
مستخلص:	Purpose: Vitamin A deficiency (VAD) remains a significant contributor to childhood morbidity and mortality in developing countries; therefore, the implementation of sustainable and cost-effective approaches to control VAD is of utmost pertinence. This study aims to investigate the efficacy of red palm olein (RPO)-enriched biscuit supplementation in improving vitamin A, haematological, iron, and inflammatory status among vitamin A-deficient schoolchildren. Methods: We conducted a double-blinded, randomised controlled trial involving 651 rural primary schoolchildren (8-12 years) with VAD in Malaysia. The schoolchildren were randomised to receive either RPO-enriched biscuits (experimental group, n = 334) or palm olein-enriched biscuits (control group, n = 317) for 6-month duration. Results: Significant improvements in retinol and retinol-binding protein 4 levels were observed in both groups after supplementation (P < 0.001). The improvement in retinol levels were similar across groups among subjects with confirmed VAD (P = 0.40). Among those with marginal VAD, greater improvement in retinol levels was recorded in the control group (P < 0.001) but lacked clinical significance. The levels of α- and β-carotenes, haematological parameters (haemoglobin, packed cell volume, mean corpuscular volume and mean corpuscular haemoglobin) and iron enhanced more significantly in the experimental group (P < 0.05). The significant reduction in the prevalence of microcytic anaemia (- 21.8%) and high inflammation (- 8.1%) was only observed in the experimental group. Conclusion: The supplementation of RPO-enriched biscuits enhanced levels of provitamin A carotenes, iron, and erythropoiesis, and exhibited anti-inflammatory effects. Therefore, the incorporation of RPO into National Nutritional Intervention Programs may be a potential measure to improve the health status of vitamin A-deficient children, among various other interventions. Clinical Trial Registration: ClinicalTrials.gov (NCT03256123). (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
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معلومات مُعتمدة:	RMK-11 Grant-PD219/16 Malaysian Palm Oil Board
فهرسة مساهمة:	Keywords: Carotene; Erythropoiesis; Inflammation; Iron; Red palm olein; Vitamin A deficiency
سلسلة جزيئية:	ClinicalTrials.gov NCT03256123
المشرفين على المادة:	11103-57-4 (Vitamin A) 36-88-4 (Carotenoids) 0 (Provitamins) E1UOL152H7 (Iron)
تواريخ الأحداث:	Date Created: 20240119 Date Completed: 20240319 Latest Revision: 20240410
رمز التحديث:	20240410
DOI:	10.1007/s00394-023-03314-6
PMID:	38240773
قاعدة البيانات:	MEDLINE

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