دورية أكاديمية

Using the Right Criteria for MCAS.

التفاصيل البيبلوغرافية
العنوان: Using the Right Criteria for MCAS.
المؤلفون: Gulen T; Department of Respiratory Medicine and Allergy, K85, Karolinska University Hospital Huddinge, Stockholm, SE-14186, Sweden. theo.gulen@ki.se.; Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. theo.gulen@ki.se.; Clinical Lung and Allergy Research Unit, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. theo.gulen@ki.se.; Mastocytosis Centre Karolinska, Karolinska University Hospital Huddinge, Stockholm, Sweden. theo.gulen@ki.se.
المصدر: Current allergy and asthma reports [Curr Allergy Asthma Rep] 2024 Feb; Vol. 24 (2), pp. 39-51. Date of Electronic Publication: 2024 Jan 20.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Current Science Inc Country of Publication: United States NLM ID: 101096440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-6315 (Electronic) Linking ISSN: 15297322 NLM ISO Abbreviation: Curr Allergy Asthma Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : Current Science Inc., c2001-
مواضيع طبية MeSH: Mastocytosis* , Mast Cell Activation Syndrome*, Humans ; Tryptases ; Mast Cells ; Diagnosis, Differential
مستخلص: Purpose of Review: The current article aims to provide a comprehensive update on diagnostic criteria for mast cell activation syndrome (MCAS), addressing challenges in diagnosing and classifying MCAS and its variants.
Recent Findings: In recent years, there has been a significant increase in our knowledge regarding the underlying mechanisms responsible for the activation of mast cells (MCs) in various pathological conditions. Furthermore, a set of criteria and a classification for MCASs have been established. MCAS is characterized by the presence of typical clinical symptoms, a substantial elevation in serum tryptase levels during an attack compared to the patient's baseline tryptase levels, and a response to MC mediator-targeting therapy. In this report, a thorough examination was conducted on the contemporary literature relating to MCAS, with a focus on comparing the specificity, sensitivity, and robustness of MCAS-related parameters within proposals for diagnosing and classifying MCAS and its variants. Moreover, the significance of employing specific consensus criteria in the assessment and categorization of MCAS in individual patients was underscored, due to the escalating occurrence of patients receiving a misdiagnosis of MCAS based on nonspecific criteria.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Anaphylaxis; Hereditary alpha-tryptasemia; MCAS; Mast cell activation; Mastocytosis; Tryptase
المشرفين على المادة: EC 3.4.21.59 (Tryptases)
تواريخ الأحداث: Date Created: 20240119 Date Completed: 20240215 Latest Revision: 20240524
رمز التحديث: 20240525
مُعرف محوري في PubMed: PMC10866766
DOI: 10.1007/s11882-024-01126-0
PMID: 38243020
قاعدة البيانات: MEDLINE
الوصف
تدمد:1534-6315
DOI:10.1007/s11882-024-01126-0