دورية أكاديمية
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Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.

التفاصيل البيبلوغرافية
العنوان: Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
المؤلفون: Chen X; Department of Arthroplasty, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Taizhou, Zhejiang, 317500, China.; College of Nursing, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Wang B; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Zhou Y; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Wu X; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Du A; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Al Mamun A; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; Central Research Laboratory of The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui People's Hospital, Lishui City, Zhejiang, 323000, China., Xu Y; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Wang S; Department of Arthroplasty, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Taizhou, Zhejiang, 317500, China., Jiang C; Department of Arthroplasty, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Taizhou, Zhejiang, 317500, China., Xie L; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Zhou K; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Hu S; Department of Arthroplasty, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Taizhou, Zhejiang, 317500, China., Xiao J; Department of Arthroplasty, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Taizhou, Zhejiang, 317500, China.; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
المصدر: Advanced healthcare materials [Adv Healthc Mater] 2024 May; Vol. 13 (12), pp. e2303462. Date of Electronic Publication: 2024 Feb 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim : Wiley-VCH, 2012-
مواضيع طبية MeSH: Betulinic Acid*/chemistry , Fibroblast Growth Factor 2*/administration & dosage , Fibroblast Growth Factor 2*/chemistry , Fibroblast Growth Factor 2*/pharmacology , Nanoparticles*/chemistry , Nanoparticles*/therapeutic use , Spinal Cord Injuries*/drug therapy, Animals ; Male ; Rats ; Apoptosis/drug effects ; Drug Carriers/chemistry ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Polymers/chemistry ; Rats, Sprague-Dawley ; Recovery of Function/drug effects
مستخلص: Oxidative stress (OS) is one of the crucial molecular events of secondary spinal cord injury (SCI). Basic fibroblast growth factor (bFGF) is a multipotent cell growth factor with an anti-oxidant effect. However, bFGF has a short half-life in vivo, which limits its therapeutic application. Biodegradable polymers with excellent biocompatibility have been recently applied in SCI. The negative aspect is that polymers cannot provide a significant therapeutic effect. Betulinic acid (BA), a natural anti-inflammatory compound, has been polymerized into poly (betulinic acid) (PBA) to serve as a drug carrier for bFGF. This study explores the therapeutic effects and underlying molecular mechanisms of PBA nanoparticles (NPs) loaded with bFGF (PBA-bFGF NPs) in SCI. Results show that PBA-bFGF NPs produce remarkable biocompatibility in vivo and in vitro. The results also demonstrate that local delivery of PBA-bFGF NPs enhances motor function recovery, inhibits OS, mitigates neuroinflammation, and alleviates neuronal apoptosis following SCI. Furthermore, the results indicate that local delivery of PBA-bFGF NPs activates the nuclear factor erythroid 2-related factor 2 (Nrf-2) signaling pathway following SCI. In summary, results suggest that local delivery of PBA-bFGF NPs delivers potential therapeutic advantages in the treatment and management of SCI.
(© 2024 Wiley‐VCH GmbH.)
References: X. Feng, X. Chen, M. Zaeem, W. Zhang, L. Song, L. Chen, J. Mubwandarikwa, X. Chen, J. Xiao, L. Xie, K. Ye, Oxid. Med. Cell Longev. 2022, 2022, 8010670.
K. L. Zhou, Y. F. Zhou, K. Wu, N. F. Tian, Y. S. Wu, Y. L. Wang, D. H. Chen, B. Zhou, X. Y. Wang, H. Z. Xu, X. L. Zhang, Sci. Rep. 2015, 5, 17130.
B. Fan, Z. Wei, S. Feng, Bone Res. 2022, 10, 35.
S. Fakhri, F. Abbaszadeh, S. Z. Moradi, H. Cao, H. Khan, J. Xiao, Oxid. Med. Cell Longev. 2022, 2022, 8100195.
Y. Z. Zhao, X. Q. Tian, M. Zhang, L. Cai, A. Ru, X. T. Shen, X. Jiang, R. R. Jin, L. Zheng, K. Hawkins, S. Charkrabarti, X. K. Li, Q. Lin, W. Z. Yu, S. Ge, C. T. Lu, H. L. Wong, J. Control. Release 2014, 186, 22.
J. Wu, J. Zhu, Q. Wu, Y. An, K. Wang, T. Xuan, J. Zhang, W. Song, H. He, L. Song, J. Zheng, J. Xiao, ACS Appl. Mater. Interfaces 2021, 13, 2230.
A. Cox, M. Capone, D. Matzelle, A. Vertegel, M. Bredikhin, A. Varma, A. Haque, D. C. Shields, N. L. Banik, J. Neurotrauma 2021, 38, 342.
R. Ganugula, M. Deng, M. Arora, H. L. Pan, M. Kumar, ACS Chem. Neurosci. 2019, 10, 1801.
W. J. F. Vanbilloen, J. S. Rechberger, J. B. Anderson, L. F. Nonnenbroich, L. Zhang, D. J. Daniels, Pharmaceutics 2023, 15, 1804.
O. S. Obisesan, T. O. Ajiboye, S. D. Mhlanga, H. T. Mufhandu, Colloids Surf., B: Biointerfaces 2023, 227, 113342.
Y. Lu, D. Cheng, B. Niu, X. Wang, X. Wu, A. Wang, Pharmaceuticals 2023, 16, 454.
M. Rahmanian, A. Ghahremani, P. Kesharwani, F. Oroojalian, A. Sahebkar, Environ. Res. 2023, 116563.
F. Molavi, M. Barzegar‐Jalali, H. Hamishehkar, J. Control. Release 2020, 320, 265.
F. Seidi, Y. Zhong, H. Xiao, Y. Jin, D. Crespy, Chem. Soc. Rev. 2022, 51, 6652.
K. Y. Ou, X. J. Xu, S. Y. Guan, R. H. Zhang, X. Y. Zhang, Y. Kang, J. Wu, Adv. Funct. Mater. 2020, 30, 1907857.
X. R. You, L. Y. Wang, L. Wang, J. Wu, Adv. Funct. Mater. 2021, 31, 2100805.
Y. H. Zheng, X. R. You, S. Y. Guan, J. Huang, L. Y. Wang, J. Y. Zhang, J. Wu, Adv. Funct. Mater. 2019, 29, 1808646.
J. F. Oliveira‐Costa, C. S. Meira, M. Neves, B. Dos Reis, M. B. P. Soares, Front. Pharmacol. 2022, 13, 883857.
C. Yang, Y. Chen, M. Yang, J. Li, Y. Wu, H. Fan, X. Kong, C. Ning, S. Wang, W. Xiao, Z. Yuan, J. Yi, J. Wu, Environ. Pollut. 2023, 316, 120435.
R. Wang, X. Wang, X. Jia, H. Wang, W. Li, J. Li, Int. J. Pharm. 2020, 588, 119799.
A. P. Tran, P. M. Warren, J. Silver, Physiol. Rev. 2018, 98, 881.
B. Zheng, M. H. Tuszynski, Nat. Rev. Mol. Cell Biol. 2023, 24, 396.
X. Sun, H. Liu, Z. Tan, Y. Hou, M. Pang, S. Chen, L. Xiao, Q. Yuan, B. Liu, L. Rong, L. He, Small 2023, 19, e2205012.
Y. Hong, K. J. Palaksha, K. Park, S. Park, H. D. Kim, R. J. Reiter, K. T. Chang, J. Pineal Res. 2010, 49, 201.
D. Guimaraes, A. Cavaco‐Paulo, E. Nogueira, Int. J. Pharm. 2021, 601, 120571.
P. P. Wattamwar, S. S. Hardas, D. A. Butterfield, K. W. Anderson, T. D. Dziubla, J. Biomed. Mater. Res. A 2011, 99, 184.
Y. C. Boo, Antioxidants 2019, 8, 275.
J. Hu, Y. Song, C. Zhang, W. Huang, A. Chen, H. He, S. Zhang, Y. Chen, C. Tu, J. Liu, X. Xuan, Y. Chang, J. Zheng, J. Wu, ACS Appl. Biol. Mater. 2020, 3, 965.
W. Jiang, M. Li, F. He, L. Zhu, J. Cell. Physiol. 2019, 234, 6012.
D. M. Basso, L. C. Fisher, A. J. Anderson, L. B. Jakeman, D. M. McTigue, P. G. Popovich, J. Neurotrauma 2006, 23, 635.
معلومات مُعتمدة: 82172428 National Natural Science Foundation of China; 81972150 National Natural Science Foundation of China; LQ21H090001 Natural Science Foundation of Zhejiang Provincial
فهرسة مساهمة: Keywords: Oxidative stress; Poly (betulinic acid) nanoparticles; Spinal cord injury; bFGF
المشرفين على المادة: 4G6A18707N (Betulinic Acid)
0 (Drug Carriers)
103107-01-3 (Fibroblast Growth Factor 2)
0 (NF-E2-Related Factor 2)
0 (Polymers)
تواريخ الأحداث: Date Created: 20240120 Date Completed: 20240507 Latest Revision: 20240628
رمز التحديث: 20240628
DOI: 10.1002/adhm.202303462
PMID: 38243745
قاعدة البيانات: MEDLINE
الوصف
تدمد:2192-2659
DOI:10.1002/adhm.202303462