دورية أكاديمية
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
العنوان: | Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury. |
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المؤلفون: | Chen X; Department of Arthroplasty, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Taizhou, Zhejiang, 317500, China.; College of Nursing, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Wang B; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Zhou Y; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Wu X; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Du A; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Al Mamun A; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; Central Research Laboratory of The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui People's Hospital, Lishui City, Zhejiang, 323000, China., Xu Y; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Wang S; Department of Arthroplasty, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Taizhou, Zhejiang, 317500, China., Jiang C; Department of Arthroplasty, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Taizhou, Zhejiang, 317500, China., Xie L; School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Zhou K; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China., Hu S; Department of Arthroplasty, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Taizhou, Zhejiang, 317500, China., Xiao J; Department of Arthroplasty, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Taizhou, Zhejiang, 317500, China.; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. |
المصدر: | Advanced healthcare materials [Adv Healthc Mater] 2024 May; Vol. 13 (12), pp. e2303462. Date of Electronic Publication: 2024 Feb 05. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Weinheim : Wiley-VCH, 2012- |
مواضيع طبية MeSH: | Betulinic Acid*/chemistry , Fibroblast Growth Factor 2*/administration & dosage , Fibroblast Growth Factor 2*/chemistry , Fibroblast Growth Factor 2*/pharmacology , Nanoparticles*/chemistry , Nanoparticles*/therapeutic use , Spinal Cord Injuries*/drug therapy, Animals ; Male ; Rats ; Apoptosis/drug effects ; Drug Carriers/chemistry ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Polymers/chemistry ; Rats, Sprague-Dawley ; Recovery of Function/drug effects |
مستخلص: | Oxidative stress (OS) is one of the crucial molecular events of secondary spinal cord injury (SCI). Basic fibroblast growth factor (bFGF) is a multipotent cell growth factor with an anti-oxidant effect. However, bFGF has a short half-life in vivo, which limits its therapeutic application. Biodegradable polymers with excellent biocompatibility have been recently applied in SCI. The negative aspect is that polymers cannot provide a significant therapeutic effect. Betulinic acid (BA), a natural anti-inflammatory compound, has been polymerized into poly (betulinic acid) (PBA) to serve as a drug carrier for bFGF. This study explores the therapeutic effects and underlying molecular mechanisms of PBA nanoparticles (NPs) loaded with bFGF (PBA-bFGF NPs) in SCI. Results show that PBA-bFGF NPs produce remarkable biocompatibility in vivo and in vitro. The results also demonstrate that local delivery of PBA-bFGF NPs enhances motor function recovery, inhibits OS, mitigates neuroinflammation, and alleviates neuronal apoptosis following SCI. Furthermore, the results indicate that local delivery of PBA-bFGF NPs activates the nuclear factor erythroid 2-related factor 2 (Nrf-2) signaling pathway following SCI. In summary, results suggest that local delivery of PBA-bFGF NPs delivers potential therapeutic advantages in the treatment and management of SCI. (© 2024 Wiley‐VCH GmbH.) |
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معلومات مُعتمدة: | 82172428 National Natural Science Foundation of China; 81972150 National Natural Science Foundation of China; LQ21H090001 Natural Science Foundation of Zhejiang Provincial |
فهرسة مساهمة: | Keywords: Oxidative stress; Poly (betulinic acid) nanoparticles; Spinal cord injury; bFGF |
المشرفين على المادة: | 4G6A18707N (Betulinic Acid) 0 (Drug Carriers) 103107-01-3 (Fibroblast Growth Factor 2) 0 (NF-E2-Related Factor 2) 0 (Polymers) |
تواريخ الأحداث: | Date Created: 20240120 Date Completed: 20240507 Latest Revision: 20240628 |
رمز التحديث: | 20240628 |
DOI: | 10.1002/adhm.202303462 |
PMID: | 38243745 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2192-2659 |
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DOI: | 10.1002/adhm.202303462 |