دورية أكاديمية
Role of Histiocyte-Derived frHMGB1 as a Facilitator in Noncanonical Pyroptosis of Monocytes/Macrophages in Lethal Sepsis.
| العنوان: | Role of Histiocyte-Derived frHMGB1 as a Facilitator in Noncanonical Pyroptosis of Monocytes/Macrophages in Lethal Sepsis. |
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| المؤلفون: | Tian Y; Institute for Medical Immunology, the Affiliated Hospital of Jiangsu University.; International Genome Center, Jiangsu University., Cao Y; Institute for Medical Immunology, the Affiliated Hospital of Jiangsu University.; International Genome Center, Jiangsu University., Liu F; Institute for Medical Immunology, the Affiliated Hospital of Jiangsu University.; International Genome Center, Jiangsu University., Xia L; Institute for Medical Immunology, the Affiliated Hospital of Jiangsu University.; Department of Laboratory Medicine, the Affiliated Hospital of Jiangsu University, Zhenjiang, China., Wang C; Institute for Medical Immunology, the Affiliated Hospital of Jiangsu University.; International Genome Center, Jiangsu University., Su Z; Institute for Medical Immunology, the Affiliated Hospital of Jiangsu University.; International Genome Center, Jiangsu University. |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2024 Aug 16; Vol. 230 (2), pp. 298-308. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مواضيع طبية MeSH: | Pyroptosis* , Sepsis*/metabolism , Macrophages*/metabolism , HMGB1 Protein*/metabolism , Monocytes*/metabolism , Lipopolysaccharides*, Animals ; Mice ; Humans ; Mice, Inbred C57BL ; Caspases, Initiator/metabolism ; Caspases, Initiator/genetics ; Caspases/metabolism ; Receptor for Advanced Glycation End Products/metabolism ; Male ; Disease Models, Animal |
| مستخلص: | In this study, we investigated the role of the noncanonical pyroptosis pathway in the progression of lethal sepsis. Our findings emphasize the significance of noncanonical pyroptosis in monocytes/macrophages for the survival of septic mice. We observed that inhibiting pyroptosis alone significantly improved the survival rate of septic mice and that the HMGB1 A box effectively suppressed this noncanonical pyroptosis, thereby enhancing the survival of septic mice. Additionally, our cell in vitro experiments unveiled that frHMGB1, originating from lipopolysaccharide-carrying histiocytes, entered macrophages via RAGE, resulting in the direct activation of caspase 11 and the induction of noncanonical pyroptosis. Notably, A box's competitive binding with lipopolysaccharide impeded its entry into the cell cytosol. These findings reveal potential therapeutic strategies for slowing the progression of lethal sepsis by modulating the noncanonical pyroptosis pathway. Competing Interests: Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| معلومات مُعتمدة: | 2019-WSN-122 Six Talent Peaks Project in Jiangsu Province; BX2019100 Projects of International Cooperation from Jiangsu |
| فهرسة مساهمة: | Keywords: HMGB1; macrophage; pyroptosis; sepsis |
| المشرفين على المادة: | 0 (HMGB1 Protein) 0 (Lipopolysaccharides) EC 3.4.22.- (Caspases, Initiator) EC 3.4.22.- (Casp4 protein, mouse) EC 3.4.22.- (Caspases) 0 (Receptor for Advanced Glycation End Products) 0 (HMGB1 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20240120 Date Completed: 20240815 Latest Revision: 20240815 |
| رمز التحديث: | 20240816 |
| DOI: | 10.1093/infdis/jiae020 |
| PMID: | 38243905 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6613 |
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| DOI: | 10.1093/infdis/jiae020 |