دورية أكاديمية
Association of cord plasma metabolites with birth weight: results from metabolomic and lipidomic studies of discovery and validation cohorts.
| العنوان: | Association of cord plasma metabolites with birth weight: results from metabolomic and lipidomic studies of discovery and validation cohorts. |
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| المؤلفون: | Xie Y; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Fang X; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Wang A; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Xu S; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; School of Environmental Science and Engineering, Hainan University, Haikou, Hainan, China., Li Y; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Xia W; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. |
| المصدر: | Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology [Ultrasound Obstet Gynecol] 2024 Jul; Vol. 64 (1), pp. 87-96. Date of Electronic Publication: 2024 Jun 10. |
| نوع المنشور: | Journal Article; Validation Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons, Ltd Country of Publication: England NLM ID: 9108340 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-0705 (Electronic) Linking ISSN: 09607692 NLM ISO Abbreviation: Ultrasound Obstet Gynecol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : Chichester, West Sussex, UK : John Wiley & Sons, Ltd. Original Publication: Carnforth, Lancs, UK ; Park Ridge, N.J., USA : Parthenon Pub., c1991- |
| مواضيع طبية MeSH: | Fetal Blood*/metabolism , Fetal Blood*/chemistry , Birth Weight* , Metabolomics*/methods , Infant, Small for Gestational Age* , Lipidomics*, Humans ; Female ; Infant, Newborn ; Pregnancy ; Adult ; China ; Male ; Cohort Studies ; Gestational Age ; Infant, Low Birth Weight ; Metabolome |
| مستخلص: | Objective: Birth weight is a good predictor of fetal intrauterine growth and long-term health, and several studies have evaluated the relationship between metabolites and birth weight. The aim of this study was to investigate the association of cord blood metabolomics and lipidomics with birth weight, using a two-stage discovery and validation approach. Methods: Firstly, a pseudotargeted metabolomics approach was applied to detect metabolites in 504 cord blood samples in the discovery set enrolled from the Wuhan Healthy Baby Cohort, China. Metabolome-wide association scan analysis and pathway enrichment were applied to identify metabolites and metabolic pathways that were significantly associated with birth weight adjusted for gestational age Z-score (BW Z-score). Logistic regression models were used to analyze the association of metabolites in the most significantly associated pathways with small-for-gestational age (SGA) at delivery and low birth weight (LBW). Subsequently, 350 cord blood samples in a validation cohort were subjected to targeted analysis to validate the metabolites identified by screening in the discovery cohort. Results: In the discovery set, of 2566 metabolites detected, 2418 metabolites were retained for subsequent analysis after data preprocessing. Of these, 513 metabolites were significantly associated with BW Z-score (P-value adjusted for false discovery rate (P Conclusions: These results indicate a significant association of elevated primary bile acids, particularly TCDCA and TCA, in cord blood with lower BW Z-score, as well as increased risk of SGA and LBW. Abnormalities of primary bile acid metabolism may play an important role in restricted fetal development. © 2024 International Society of Ultrasound in Obstetrics and Gynecology. (© 2024 International Society of Ultrasound in Obstetrics and Gynecology.) |
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| معلومات مُعتمدة: | 2015ZDTD047 National Natural Science Foundation of China; 42277428 National Natural Science Foundation of China; U21A20397 National Natural Science Foundation of China; 2018QYTD12 Program for HUST Academic Frontier Youth Team; 2022YFE0132900 the National Key Research and Development Plan of China |
| فهرسة مساهمة: | Keywords: birth weight; cohort; mass spectrometry; metabolomic; primary bile acid |
| تواريخ الأحداث: | Date Created: 20240120 Date Completed: 20240701 Latest Revision: 20240701 |
| رمز التحديث: | 20240701 |
| DOI: | 10.1002/uog.27591 |
| PMID: | 38243991 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1469-0705 |
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| DOI: | 10.1002/uog.27591 |