دورية أكاديمية
أعرض في EDS

Expression and potential regulatory functions of Drosophila octopamine receptors in the female reproductive tract.

التفاصيل البيبلوغرافية
العنوان: Expression and potential regulatory functions of Drosophila octopamine receptors in the female reproductive tract.
المؤلفون: Rohrbach EW; Interdepartmental Program in Neuroscience, Brain Research Institute, Gonda (Goldschmied) Neuroscience and Genetics Research Center, UCLA, Los Angeles, CA 90095, USA., Knapp EM; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA., Deshpande SA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA., Krantz DE; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
المصدر: G3 (Bethesda, Md.) [G3 (Bethesda)] 2024 Mar 06; Vol. 14 (3).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101566598 Publication Model: Print Cited Medium: Internet ISSN: 2160-1836 (Electronic) Linking ISSN: 21601836 NLM ISO Abbreviation: G3 (Bethesda) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : [Oxford] : Oxford University Press
Original Publication: Bethesda, MD : Genetics Society of America, 2011-
مواضيع طبية MeSH: Drosophila*/metabolism , Drosophila Proteins*/metabolism , Receptors, Biogenic Amine*, Animals ; Female ; Male ; Drosophila melanogaster/metabolism ; Octopamine/metabolism ; Semen/metabolism ; Mammals
مستخلص: Aminergic signaling is known to play a critical role in regulating female reproductive processes in both mammals and insects. In Drosophila, the ortholog of noradrenaline, octopamine, is required for ovulation as well as several other female reproductive processes. Two octopamine receptors have already been shown to be expressed in the Drosophila reproductive tract and to be required for egg-laying: OAMB and Octβ2R. The Drosophila genome contains 4 additional octopamine receptors-Octα2R, Octβ1R, Octβ3R, and Oct-TyrR-but their cellular patterns of expression in the reproductive tract and potential contribution(s) to egg-laying are not known. In addition, the mechanisms by which OAMB and Octβ2R regulate reproduction are incompletely understood. Using a panel of MiMIC Gal4 lines, we show that Octα2R, Octβ1R, Octβ3R, and Oct-TyrR receptors are not detectable in either epithelium or muscle but are clearly expressed in neurons within the female fly reproductive tract. Optogenetic activation of neurons that express at least 3 types of octopamine receptors stimulates contractions in the lateral oviduct. We also find that octopamine stimulates calcium transients in the sperm storage organs and that its effects in spermathecal, secretory cells, can be blocked by knock-down of OAMB. These data extend our understanding of the pathways by which octopamine regulates egg-laying in Drosophila and raise the possibility that multiple octopamine receptor subtypes could play a role in this process.
Competing Interests: Conflicts of interest The authors declare no conflicts of interest.
(© The Author(s) 2024. Published by Oxford University Press on behalf of The Genetics Society of America.)
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معلومات مُعتمدة: F32 NS123014 United States NS NINDS NIH HHS; R24 OD031447 United States OD NIH HHS; R01MH107390 United States NH NIH HHS; R01 MH114017 United States MH NIMH NIH HHS; T32 DA024635 United States DA NIDA NIH HHS
فهرسة مساهمة: Keywords: egg-laying; octopamine; octopamine receptor; oviposition; spermatheca
المشرفين على المادة: 0 (norsynephrine receptor)
14O50WS8JD (Octopamine)
0 (Drosophila Proteins)
0 (Receptors, Biogenic Amine)
تواريخ الأحداث: Date Created: 20240120 Date Completed: 20240308 Latest Revision: 20240521
رمز التحديث: 20240521
مُعرف محوري في PubMed: PMC10917510
DOI: 10.1093/g3journal/jkae012
PMID: 38244217
قاعدة البيانات: MEDLINE
الوصف
تدمد:2160-1836
DOI:10.1093/g3journal/jkae012