دورية أكاديمية
أعرض في EDS

Effect of Hospital Cancer Designation on use of Multimodal Therapy and Survival of Metastatic Colorectal Cancer: A State-Wide Analysis.

التفاصيل البيبلوغرافية
العنوان: Effect of Hospital Cancer Designation on use of Multimodal Therapy and Survival of Metastatic Colorectal Cancer: A State-Wide Analysis.
المؤلفون: Meier J; Department of Surgery, University of Texas Southwestern, Dallas, TX, USA., Murimwa G; Department of Surgery, University of Texas Southwestern, Dallas, TX, USA., Nehrubabu M; Department of Mathematics, University of Texas at Dallas, Dallas, TX, USA., DiMartino L; Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern, Dallas, TX, USA., Singal AG; Division of Digestive & Liver Diseases, University of Texas Southwestern, Dallas, TX, USA., Karagkounis G; Department of Surgery, University of Texas Southwestern, Dallas, TX, USA., Yopp A; Department of Surgery, University of Texas Southwestern, Dallas, TX, USA., Zeh HJ 3rd; Department of Surgery, University of Texas Southwestern, Dallas, TX, USA., Polanco PM; Department of Surgery, University of Texas Southwestern, Dallas, TX, USA. patricio.polanco@utsouthwestern.edu.
المصدر: Annals of surgical oncology [Ann Surg Oncol] 2024 Apr; Vol. 31 (4), pp. 2591-2597. Date of Electronic Publication: 2024 Jan 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 9420840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4681 (Electronic) Linking ISSN: 10689265 NLM ISO Abbreviation: Ann Surg Oncol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : New York, NY : Springer
Original Publication: New York, NY : Raven Press, c1994-
مواضيع طبية MeSH: Colonic Neoplasms* , Rectal Neoplasms* , Colorectal Neoplasms*/therapy, Humans ; Combined Modality Therapy ; Proportional Hazards Models ; Hospitals ; Retrospective Studies
مستخلص: Background: Stage IV colorectal cancer (CRC) often requires multidisciplinary approach. However, multimodal treatment options (receipt of > 1 type of treatment) may not be uniformly delivered across health systems. We characterized the association between center-level cancer center designation and receipt of multimodal treatment and survival.
Methods: The Texas Cancer Registry was used to identify patients diagnosed with stage IV CRC from 2004-2017. We identified those who received care at either: a National Cancer Institute-designated (NCI-D), an American College of Surgeons-Commission on Cancer-designated (ACS-D), or an undesignated facility. We used multivariable logistic regression and Cox regression for analysis to assess receipt of one or more treatment modality and 5-year overall survival.
Results: Of 19,355 patients with stage IV CRC, 2955 (15%) received care at an NCI-D facility and 5871 (30%) received multimodal therapy. Both NCI-D (odds ratio [OR] 1.64; 95% confidence interval [CI] 1.49-1.81) and ACS-D (OR 1.37; 95% CI 1.27-1.48) were associated with increased likelihood of multimodal therapy compared with undesignated centers. NCI-D also was associated with significantly improved survival (hazard ratio [HR] 0.74; 95% CI 0.70-0.78), although ACS-D was associated with a modest improvement in survival (HR 0.95; 95% CI 0.92-0.99). Receipt of multimodal therapy was strongly associated with improved survival (HR 0.61; 95% CI 0.59-0.63).
Conclusions: In patients with stage IV CRC, treatment at ACS-D and NCI-D facilities was associated with increased use of multimodality therapy and improved survival. However, only a small proportion of patients have access to these specialized centers, highlighting a need for expanded access to multimodal therapies at other centers.
(© 2024. Society of Surgical Oncology.)
References: Cancer Stat Facts: Colorectal Cancer. Accessed 10 March 2022. https://seer.cancer.gov/statfacts/html/colorect.html.
Key Statistics for Colorectal Cancer. Accessed 10 Oct 2020. https://www.cancer.org/cancer/colon-rectal-cancer/about/key-statistics.html.
Van Cutsem E, Cervantes A, Nordlinger B, Arnold D, Group EWG. Metastatic colorectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014;25(Suppl 3):iii1-9. https://doi.org/10.1093/annonc/mdu260 . (PMID: 10.1093/annonc/mdu26025190710)
Zhang GQ, Taylor JP, Stem M, et al. Aggressive multimodal treatment and metastatic colorectal cancer survival. J Am Coll Surg. 2020;230(4):689–98. https://doi.org/10.1016/j.jamcollsurg.2019.12.024 . (PMID: 10.1016/j.jamcollsurg.2019.12.02432014570)
NCI-Designated Cancer Centers. Accessed 10 March 2022. https://www.cancer.gov/research/infrastructure/cancer-centers.
Commission on Cancer. Accessed 10 March 2023. https://www.facs.org/quality-programs/cancer-programs/commission-on-cancer/.
Murimwa GZ, Karalis JD, Meier J, et al. Hospital designations and their impact on guideline-concordant care and survival in pancreatic cancer. Do they matter? Ann Surg Oncol. 2023. https://doi.org/10.1245/s10434-023-13308-7 . (PMID: 10.1245/s10434-023-13308-737052823)
Texas Cancer Registry. Accessed 16 March 2023. https://www.dshs.texas.gov/texas-cancer-registry.
Ju MR, Karalis JD, Bhat A, et al. Nativity status is an important social determinant of health for hispanic patients with gastric cancer in Texas. Ann Surg Oncol. 2022;29(5):3113–21. https://doi.org/10.1245/s10434-021-11188-3 . (PMID: 10.1245/s10434-021-11188-335028796)
Feo L, Polcino M, Nash GM. Resection of the primary tumor in stage IV colorectal cancer: When is it necessary? Surg Clin North Am. 2017;97(3):657–69. https://doi.org/10.1016/j.suc.2017.01.012 . (PMID: 10.1016/j.suc.2017.01.012285012535590838)
Adam R, Vinet E. Regional treatment of metastasis: surgery of colorectal liver metastases. Ann Oncol. 2004;15(Suppl 4):iv103–6. https://doi.org/10.1093/annonc/mdh912 . (PMID: 10.1093/annonc/mdh91215477291)
Fong ZV, Chang DC, Hur C, et al. Variation in long-term oncologic outcomes by type of cancer center accreditation: an analysis of a SEER-Medicare population with pancreatic cancer. Am J Surg. 2020;220(1):29–34. https://doi.org/10.1016/j.amjsurg.2020.03.035 . (PMID: 10.1016/j.amjsurg.2020.03.035322650138350560)
Huo YR, Phan K, Morris DL, Liauw W. Systematic review and a meta-analysis of hospital and surgeon volume/outcome relationships in colorectal cancer surgery. J Gastrointest Oncol. 2017;8(3):534–46. https://doi.org/10.21037/jgo.2017.01.25 . (PMID: 10.21037/jgo.2017.01.25287366405506277)
Lam MB, Figueroa JF, Feyman Y, Reimold KE, Orav EJ, Jha AK. Association between patient outcomes and accreditation in US hospitals: observational study. BMJ. 2018;363:k4011. https://doi.org/10.1136/bmj.k4011 . (PMID: 10.1136/bmj.k4011303372946193202)
Teh SH, Uong S, Lin TY, et al. Clinical outcomes following regionalization of gastric cancer care in a US integrated health care system. J Clin Oncol. 2021;39(30):3364–76. https://doi.org/10.1200/JCO.21.00480 . (PMID: 10.1200/JCO.21.0048034339289)
Latenstein AEJ, Mackay TM, van der Geest LGM, et al. Effect of centralization and regionalization of pancreatic surgery on resection rates and survival. Br J Surg. 2021;108(7):826–33. https://doi.org/10.1093/bjs/znaa146 . (PMID: 10.1093/bjs/znaa14633738473)
Resio BJ, Chiu AS, Hoag JR, et al. Motivators, barriers, and facilitators to traveling to the safest hospitals in the United States for complex cancer surgery. JAMA Netw Open. 2018;1(7):e184595. https://doi.org/10.1001/jamanetworkopen.2018.4595 . (PMID: 10.1001/jamanetworkopen.2018.4595306463676324377)
Finlayson SR, Birkmeyer JD, Tosteson AN, Nease RF Jr. Patient preferences for location of care: implications for regionalization. Med Care. 1999;37(2):204–9. https://doi.org/10.1097/00005650-199902000-00010 . (PMID: 10.1097/00005650-199902000-0001010024124)
Levine RA, Chawla B, Bergeron S, Wasvary H. Multidisciplinary management of colorectal cancer enhances access to multimodal therapy and compliance with National Comprehensive Cancer Network (NCCN) guidelines. Int J Colorectal Dis. 2012;27(11):1531–8. https://doi.org/10.1007/s00384-012-1501-z . (PMID: 10.1007/s00384-012-1501-z22645076)
US States-Ranked by Population. 2023. https://worldpopulationreview.com/states.
معلومات مُعتمدة: 3R01CA243577-02S1 National Cancer Institute/National Institutes of Health; 1018897 Burroughs Wellcome Fund
تواريخ الأحداث: Date Created: 20240120 Date Completed: 20240306 Latest Revision: 20240306
رمز التحديث: 20240306
DOI: 10.1245/s10434-023-14859-5
PMID: 38245645
قاعدة البيانات: MEDLINE
الوصف
تدمد:1534-4681
DOI:10.1245/s10434-023-14859-5