دورية أكاديمية
أعرض في EDS

The Amazonian Camu-Camu Fruit Modulates the Development of Drosophila melanogaster and the Neural Function of Adult Flies under Oxidative Stress Conditions.

التفاصيل البيبلوغرافية
العنوان: The Amazonian Camu-Camu Fruit Modulates the Development of Drosophila melanogaster and the Neural Function of Adult Flies under Oxidative Stress Conditions.
المؤلفون: Musachio EAS; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Itaqui 97650-000, RS, Brazil., Pires RG; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Itaqui 97650-000, RS, Brazil., Fernandes EJ; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Itaqui 97650-000, RS, Brazil., Andrade S; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Itaqui 97650-000, RS, Brazil., Meichtry LB; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Itaqui 97650-000, RS, Brazil., Janner DE; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Itaqui 97650-000, RS, Brazil., Meira GM; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil., Ribeiro EE; Center for Research, Teaching and Technological Development-GERONTEC, Open University Foundation for the Elderly, Manaus 69029-040, AM, Brazil., Barbisan F; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil.; Graduate Program in Gerontology, Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil.; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil., Cruz IBMD; Laboratory of Biogenomics, Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil.; Graduate Program in Gerontology, Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil.; Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil., Prigol M; Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa, Itaqui 97650-000, RS, Brazil.
المصدر: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2024 Jan 15; Vol. 13 (1). Date of Electronic Publication: 2024 Jan 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101668981 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3921 (Print) Linking ISSN: 20763921 NLM ISO Abbreviation: Antioxidants (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: Camu-camu ( Myrciaria dubia ) is known for its antioxidant properties, although little is known about its developmental safety effects, particularly on adult neural function under basal redox and oxidative stress conditions. Therefore, this study sought to address this gap by conducting three complementary protocols using Drosophila melanogaster to investigate these effects. The initial assays revealed that second-stage larvae consumed diets supplemented with various concentrations of camu-camu uniformly, establishing a 50% lethal concentration at 4.799 mg/mL. Hence, non-lethal (0.1, 0.5, and 1 mg/mL) and sub-lethal (5 and 10 mg/mL) concentrations were then chosen to evaluate the effects of camu-camu on preimaginal development and adult neural function. Our observations showed that camu-camu impacts the expression of antioxidant enzymes, reactive species, and lipoperoxidation. Notably, sub-lethal concentrations decreased preimaginal viability and locomotor activity, negatively influenced geotaxis and acetylcholinesterase activity, and increased reactive species, catalase, and glutathione S-transferase activity in flies. Additionally, the protective effects of camu-camu against oxidative stress induced by iron (20 mM) were assessed. Flies supplemented with 0.5 mg/mL of camu-camu during the larval period showed improved neural viability and function, and this supplementation was found to protect against oxidative stress. These findings are instrumental in evaluating the safety and efficacy of commercial supplements based on camu-camu, offering significant insights for future research and application.
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معلومات مُعتمدة: 308120/2020-5 National Council for Scientific and Technological Development; PQG 19/2551-0001913-0 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Financial Code 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: Drosophila melanogaster; camu-camu; larvae; oxidative stress
تواريخ الأحداث: Date Created: 20240122 Latest Revision: 20240608
رمز التحديث: 20240608
مُعرف محوري في PubMed: PMC11154359
DOI: 10.3390/antiox13010102
PMID: 38247526
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-3921
DOI:10.3390/antiox13010102