دورية أكاديمية
أعرض في EDS

Incidence of Tracheal Stenosis in ICU Hospitalized COVID-19 Patients: Results from a Prospective, Observational, Multicenter Study.

التفاصيل البيبلوغرافية
العنوان: Incidence of Tracheal Stenosis in ICU Hospitalized COVID-19 Patients: Results from a Prospective, Observational, Multicenter Study.
المؤلفون: Perroni G; Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy., Radovanovic D; Division of Respiratory Diseases, L. Sacco University Hospital, ASST Fatebenefratelli-Sacco, Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, 20157 Milan, Italy., Mondoni M; Respiratory Unit, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, 20122 Milan, Italy., Mangiameli G; Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.; Department of Biomedical Sciences, Humanitas University, 20072 Milan, Italy., Giudici VM; Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.; Department of Biomedical Sciences, Humanitas University, 20072 Milan, Italy., Crepaldi A; Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy., Giatti V; Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy., Morenghi E; Biostatistics Unit, IRCCS Humanitas Research Hospital, 20089 Milan, Italy., Stella GM; Department of Internal Medicine and Medical Therapeutics, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy.; Unit of Respiratory Diseases, Cardio-Thoraco-Vascular Department, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy., Pavesi S; Respiratory Unit, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, 20122 Milan, Italy., Mantero M; Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy., Corsico AG; Department of Internal Medicine and Medical Therapeutics, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy.; Unit of Respiratory Diseases, Cardio-Thoraco-Vascular Department, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy., Spotti M; Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy., Premuda C; Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy., Mangili SA; Otolarygoiatry Unit, Sant'anna Istitute, 25127 Brescia, Italy., Franceschi E; Division of Respiratory Diseases, L. Sacco University Hospital, ASST Fatebenefratelli-Sacco, Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, 20157 Milan, Italy., Narvena VM; Unit of Pneumology of Codogno, ASST Lodi, 26845 Lodi, Italy., Vanoni N; Unit of Pneumology, ASST Lodi, 26900 Lodi, Italy., Pilocane T; Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy., Russo G; Unit of Pain Medicine, Department of Emergency, ASST Lodi, 26900 Lodi, Italy., Di Marco F; Department of Health Sciences, Università degli Studi di Milano, Pneumologia, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy., Alloisio M; Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.; Department of Biomedical Sciences, Humanitas University, 20072 Milan, Italy., Aliberti S; Department of Biomedical Sciences, Humanitas University, 20072 Milan, Italy.; Unit of Pneumology, IRCCS Humanitas Research Hospital, 20089 Milan, Italy., Marulli G; Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.; Department of Biomedical Sciences, Humanitas University, 20072 Milan, Italy., Bertuzzi AF; Department of Oncology & Hematology, IRCCS Humanitas Research Hospital, 20089 Milan, Italy., Cipolla G; Unit of Pneumology, ASST Lodi, 26900 Lodi, Italy., Centanni S; Division of Respiratory Diseases, L. Sacco University Hospital, ASST Fatebenefratelli-Sacco, Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, 20157 Milan, Italy., Blasi F; Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy., Santus P; Division of Respiratory Diseases, L. Sacco University Hospital, ASST Fatebenefratelli-Sacco, Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, 20157 Milan, Italy., Cariboni U; Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
المصدر: Journal of personalized medicine [J Pers Med] 2023 Dec 28; Vol. 14 (1). Date of Electronic Publication: 2023 Dec 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101602269 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4426 (Print) Linking ISSN: 20754426 NLM ISO Abbreviation: J Pers Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2011-
مستخلص: Background: Tracheal stenosis represents a fearsome complication that substantially impairs quality of life. The recent SARS-CoV-2 pandemic increased the number of patients requiring invasive ventilation through prolonged intubation or tracheostomy, increasing the risk of tracheal stenosis. Study design and methods: In this prospective, observational, multicenter study performed in Lombardy (Italy), we have exanimated 281 patients who underwent prolonged intubation (more than 7 days) or tracheostomy for severe COVID-19. Patients underwent CT scan and spirometry 2 months after hospital discharge and a subsequent clinical follow-up after an additional 6 months (overall 8 months of follow-up duration) to detect any tracheal lumen reduction above 1%. The last follow-up evaluation was completed on 31 August 2022. Results: In the study period, 24 patients (8.5%, CI 5.6-12.4) developed tracheal stenosis in a median time of 112 days and within a period of 200 days from intubation. Compared to patients without tracheal stenosis, tracheostomy was performed more frequently in patients that developed stenosis (75% vs 54%, p = 0.034). Tracheostomy and alcohol consumption (1 unit of alcohol per day) increased risk of developing tracheal stenosis of 2.6-fold ( p = 0.047; IC 0.99-6.8) and 5.4-fold ( p = 0.002; CI 1.9-16), respectively. Conclusions : In a large cohort of patients, the incidence of tracheal stenosis increased during pandemic, probably related to the increased use of prolonged intubation. Patients with histories of prolonged intubation should be monitored for at least 200 days from invasive ventilation in order to detect tracheal stenosis at early stage. Alcohol use and tracheostomy are risk factors for developing tracheal stenosis.
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فهرسة مساهمة: Keywords: COVID-related tracheal stenosis; SARS-CoV-2 pandemic; tracheal stenosis; tracheostomy
تواريخ الأحداث: Date Created: 20240122 Latest Revision: 20240128
رمز التحديث: 20240128
مُعرف محوري في PubMed: PMC10817429
DOI: 10.3390/jpm14010039
PMID: 38248740
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-4426
DOI:10.3390/jpm14010039