دورية أكاديمية
أعرض في EDS

Peptic ulcer characteristics in oral opium and non-opium user patients with upper gastrointestinal bleeding.

التفاصيل البيبلوغرافية
العنوان: Peptic ulcer characteristics in oral opium and non-opium user patients with upper gastrointestinal bleeding.
المؤلفون: Masoodi M; Colorectal research center, Iran University of medical sciences, Tehran, Iran. masoodi47@yahoo.com.; Colorectal research center, Hazrat Rasoul Medical Complex, Niayesh Street, Sattarkhan Avenue, Tehran, 1445613131, Iran. masoodi47@yahoo.com., Sabzikarian M; Colorectal research center, Iran University of medical sciences, Tehran, Iran., Masoodi N; Colorectal research center, Iran University of medical sciences, Tehran, Iran., Farhadi S; Colorectal research center, Iran University of medical sciences, Tehran, Iran., Rezamand GR; Colorectal research center, Iran University of medical sciences, Tehran, Iran., Tabaeian SP; Colorectal research center, Iran University of medical sciences, Tehran, Iran., Talebi A; Colorectal research center, Iran University of medical sciences, Tehran, Iran., Fayyaz F; Colorectal research center, Iran University of medical sciences, Tehran, Iran.
المصدر: BMC gastroenterology [BMC Gastroenterol] 2024 Jan 22; Vol. 24 (1), pp. 42. Date of Electronic Publication: 2024 Jan 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Opium Dependence* , Helicobacter Infections*/complications , Helicobacter pylori* , Peptic Ulcer*/complications , Duodenal Ulcer*/complications , Stomach Ulcer*/complications, Humans ; Opium/adverse effects ; Ulcer ; Cross-Sectional Studies ; Gastrointestinal Hemorrhage/chemically induced
مستخلص: Background/aims: Upper gastrointestinal bleeding (UGIB) is a frequent medical issue. The primary risk factors for bleeding peptic ulcers are Helicobacter pylori infection and non-steroidal anti-inflammatory drugs. The association between acute gastric/duodenal ulcer and opium use has been previously proposed; however, there is no available data on endoscopic findings of patients with acute UGIB who use opium.
Materials and Methods: In the present descriptive cross-sectional study, endoscopic data of 50 consecutive patients with oral opium use and 50 consecutive patients without any opium use who were admitted for UGIB were recorded. The size (5-10 mm, 11-20 mm, or more than 20 mm), number (single, double, or multiple), and location of the ulcers (esophagus, gastric corpus including the fundus and body, antrum, angulus, or duodenum) were examined by endoscopy in both groups.
Results: Three or more ulcers were observed in 46% and 16% of patients with oral opium use and without opium use, respectively (P-value = 0.001). The rate of giant ulcers (> 20 mm) was significantly higher in patients who used oral opium (40% vs. 12%; P-value = 0.007). Esophageal ulcers were also more common in oral opium users (30%) than non-users (8%) with UGIB (P-value = 0.01). Nevertheless, the location of the ulcers between the two groups generally was not statistically different.
Conclusions: This study has demonstrated that multiple, large peptic ulcers in GIB are potential complications of oral opium use. This could aid the needed modifications in the treatment protocol for these patients.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Addiction; Endoscopy; Gastrointestinal bleeding; Opium; Ulcer
المشرفين على المادة: 8008-60-4 (Opium)
تواريخ الأحداث: Date Created: 20240123 Date Completed: 20240124 Latest Revision: 20240127
رمز التحديث: 20240127
مُعرف محوري في PubMed: PMC10802017
DOI: 10.1186/s12876-024-03137-7
PMID: 38254056
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-230X
DOI:10.1186/s12876-024-03137-7