دورية أكاديمية
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Nerve Wrap for Local Delivery of FK506/Tacrolimus Accelerates Nerve Regeneration.

التفاصيل البيبلوغرافية
العنوان: Nerve Wrap for Local Delivery of FK506/Tacrolimus Accelerates Nerve Regeneration.
المؤلفون: Xiao B; Department of Plastic Surgery, University of Pittsburgh School of Medicine, Veterans Administration Healthcare System, Pittsburgh, PA 15213, USA., Feturi F; Department of Plastic Surgery, University of Pittsburgh School of Medicine, Veterans Administration Healthcare System, Pittsburgh, PA 15213, USA., Su AA; Department of Plastic Surgery, University of Pittsburgh School of Medicine, Veterans Administration Healthcare System, Pittsburgh, PA 15213, USA.; Department of Surgery, Division of Plastic Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Van der Merwe Y; Department of Ophthalmology, University of California, San Diego, CA 90095, USA., Barnett JM; Department of Plastic Surgery, University of Pittsburgh School of Medicine, Veterans Administration Healthcare System, Pittsburgh, PA 15213, USA., Jabbari K; Department of Surgery, Division of Plastic Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Khatter NJ; Department of Surgery, Division of Plastic Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Li B; Department of Surgery, Division of Plastic Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Katzel EB; Department of Plastic Surgery, University of Pittsburgh School of Medicine, Veterans Administration Healthcare System, Pittsburgh, PA 15213, USA., Venkataramanan R; University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15213, USA., Solari MG; Department of Plastic Surgery, University of Pittsburgh School of Medicine, Veterans Administration Healthcare System, Pittsburgh, PA 15213, USA., Wagner WR; McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA., Steketee MB; Department of Ophthalmology, University of California, San Diego, CA 90095, USA.; McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA., Simons DJ; McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA., Washington KM; Department of Plastic Surgery, University of Pittsburgh School of Medicine, Veterans Administration Healthcare System, Pittsburgh, PA 15213, USA.; Department of Surgery, Division of Plastic Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 10; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Tacrolimus*/pharmacology , Myelin Sheath*, Animals ; Rats ; Neurons ; Urethane ; Nerve Regeneration ; Amides ; Carbamates ; Urea ; Esters
مستخلص: Peripheral nerve injuries (PNIs) occur frequently and can lead to devastating and permanent sensory and motor function disabilities. Systemic tacrolimus (FK506) administration has been shown to hasten recovery and improve functional outcomes after PNI repair. Unfortunately, high systemic levels of FK506 can result in adverse side effects. The localized administration of FK506 could provide the neuroregenerative benefits of FK506 while avoiding systemic, off-target side effects. This study investigates the utility of a novel FK506-impregnated polyester urethane urea (PEUU) nerve wrap to treat PNI in a previously validated rat infraorbital nerve (ION) transection and repair model. ION function was assessed by microelectrode recordings of trigeminal ganglion cells responding to controlled vibrissae deflections in ION-transected and -repaired animals, with and without the nerve wrap. Peristimulus time histograms (PSTHs) having 1 ms bins were constructed from spike times of individual single units. Responses to stimulus onsets (ON responses) were calculated during a 20 ms period beginning 1 ms after deflection onset; this epoch captures the initial, transient phase of the whisker-evoked response. Compared to no-wrap controls, rats with PEUU-FK506 wraps functionally recovered earlier, displaying larger response magnitudes. With nerve wrap treatment, FK506 blood levels up to six weeks were measured nearly at the limit of quantification (LOQ ≥ 2.0 ng/mL); whereas the drug concentrations within the ION and muscle were much higher, demonstrating the local delivery of FK506 to treat PNI. An immunohistological assessment of ION showed increased myelin expression for animals assigned to neurorrhaphy with PEUU-FK506 treatment compared to untreated or systemic-FK506-treated animals, suggesting that improved PNI outcomes using PEUU-FK506 is mediated by the modulation of Schwann cell activity.
References: Exp Neurol. 2013 Sep;247:272-81. (PMID: 23707299)
J Peripher Nerv Syst. 2003 Dec;8(4):209-26. (PMID: 14641646)
Biotechnol Bioeng. 2015 Sep;112(9):1948-53. (PMID: 25850693)
J Neurophysiol. 1978 May;41(3):798-820. (PMID: 660231)
Nefrologia. 2010;30(2):259-60. (PMID: 20393625)
Exp Neurol. 1997 Oct;147(2):269-78. (PMID: 9344552)
Clin Transplant. 2011 Mar-Apr;25(2):E163-7. (PMID: 21158923)
Annu Rev Biomed Eng. 2003;5:293-347. (PMID: 14527315)
Hand Clin. 2013 Aug;29(3):317-30. (PMID: 23895713)
J Plast Reconstr Aesthet Surg. 2014 Feb;67(2):e49-53. (PMID: 24120418)
J Peripher Nerv Syst. 2010 Jun;15(2):120-7. (PMID: 20626775)
J Hand Surg Br. 1999 Feb;24(1):38-42. (PMID: 10190602)
Ann Thorac Surg. 2010 May;89(5):1664-5. (PMID: 20417810)
Clin Dev Immunol. 2013;2013:495212. (PMID: 23476677)
J Plast Reconstr Aesthet Surg. 2013 Oct;66(10):1307-15. (PMID: 23827446)
Plast Reconstr Surg. 2000 Oct;106(5):1036-45; discussion 1046-8. (PMID: 11039375)
Eur J Pharm Biopharm. 2004 Jul;58(1):37-43. (PMID: 15207535)
Plast Reconstr Surg. 2003 Dec;112(7):1832-40. (PMID: 14663227)
Gend Med. 2009;6 Suppl 2:225-34. (PMID: 19406371)
Asian Pac J Trop Med. 2014 Jun;7(6):478-82. (PMID: 25066398)
Biotechnol Bioeng. 2019 Feb;116(2):405-414. (PMID: 30345505)
Plast Reconstr Surg. 1991 Mar;87(3):401-11. (PMID: 1998012)
Pharmacol Biochem Behav. 1986 Sep;25(3):607-14. (PMID: 3774826)
Muscle Nerve. 2002 Sep;26(3):348-55. (PMID: 12210363)
J Neurotrauma. 2003 Mar;20(3):297-307. (PMID: 12820684)
EBioMedicine. 2017 Dec;26:47-59. (PMID: 29208469)
Am J Transplant. 2021 Jan;21(1):291-296. (PMID: 32484257)
Am J Phys Med Rehabil. 2008 May;87(5):381-5. (PMID: 18334923)
J Pharmacol Exp Ther. 1997 Aug;282(2):1084-93. (PMID: 9262378)
J Reconstr Microsurg. 2013 Mar;29(3):141-8. (PMID: 23322540)
J Trauma. 1998 Jul;45(1):116-22. (PMID: 9680023)
Nat Commun. 2019 Jul 5;10(1):2976. (PMID: 31278268)
Transplantation. 2005 Dec 15;80(11):1546-9. (PMID: 16371923)
Lancet. 1989 Oct 28;2(8670):1000-4. (PMID: 2478846)
J Hand Surg Am. 2020 Aug;45(8):759-765. (PMID: 32359866)
Nat Med. 1997 Apr;3(4):421-8. (PMID: 9095176)
Indian J Plast Surg. 2017 Jan-Apr;50(1):5-15. (PMID: 28615804)
Br J Pharmacol. 2012 May;166(2):637-49. (PMID: 22091865)
Bratisl Lek Listy. 2014;115(10):625-31. (PMID: 25573729)
J Oral Maxillofac Surg. 2015 Jul;73(7):1438.e1-9. (PMID: 25869987)
Hand Clin. 2015 May;31(2):151-63. (PMID: 25934193)
Neural Regen Res. 2012 Nov 15;7(32):2500-6. (PMID: 25337101)
Somatosens Mot Res. 2006 Sep-Dec;23(3-4):111-8. (PMID: 17178546)
Naunyn Schmiedebergs Arch Pharmacol. 1993 Nov;348(5):541-5. (PMID: 7509460)
Plast Reconstr Surg. 2011 Nov;128(5):510e-515e. (PMID: 22030511)
Biomed Res Int. 2014;2014:698256. (PMID: 25276813)
Neurosignals. 2004 May-Jun;13(3):122-9. (PMID: 15067199)
Prog Neurobiol. 2012 Jul;98(1):16-37. (PMID: 22609046)
Brain Res. 1970 Jan 20;17(2):205-42. (PMID: 4904874)
Muscle Nerve. 1990 Sep;13(9):771-84. (PMID: 2233864)
Restor Neurol Neurosci. 2000;16(2):77-86. (PMID: 12671210)
J Control Release. 2021 Feb 10;330:438-460. (PMID: 33352244)
J Cereb Blood Flow Metab. 2003 Oct;23(10):1183-94. (PMID: 14526229)
Curr Opin Organ Transplant. 2018 Oct;23(5):568-576. (PMID: 30074507)
Plast Reconstr Surg. 2006 Sep;118(3):615-23; discussion 624-5. (PMID: 16932168)
J Neurosci. 1997 Sep 15;17(18):6939-46. (PMID: 9278529)
Muscle Nerve. 2019 Nov;60(5):613-620. (PMID: 31397908)
Eur J Neurosci. 2015 Nov;42(10):2783-91. (PMID: 26369395)
Trends Neurosci. 1997 Feb;20(2):84-91. (PMID: 9023877)
Glia. 1997 Jun;20(2):87-100. (PMID: 9179594)
Transplant Proc. 2010 Mar;42(2):475-8. (PMID: 20304169)
J Biomed Mater Res. 2002 Sep 5;61(3):493-503. (PMID: 12115475)
Pediatr Nephrol. 2010 May;25(5):965-9. (PMID: 20091056)
Cell Biochem Biophys. 2014 Apr;68(3):449-54. (PMID: 24037713)
Exp Neurol. 2015 Feb;264:26-32. (PMID: 25446720)
Arch Iran Med. 2010 Mar;13(2):116-9. (PMID: 20187665)
Plast Reconstr Surg. 1990 Mar;85(3):419-24. (PMID: 2154831)
Expert Rev Clin Pharmacol. 2019 Nov;12(11):1047-1057. (PMID: 31575290)
Curr Opin Neurobiol. 2013 Dec;23(6):1041-8. (PMID: 23896313)
Sci Rep. 2018 Mar 14;8(1):4474. (PMID: 29540763)
J Biomed Mater Res A. 2004 Sep 15;70(4):603-14. (PMID: 15307165)
J Neurophysiol. 2016 Mar;115(3):1458-67. (PMID: 26792886)
Biomaterials. 2011 May;32(13):3387-94. (PMID: 21303718)
Brain Res. 1983 Oct 3;276(1):178-82. (PMID: 6626997)
فهرسة مساهمة: Keywords: biopolymer; immunology; infraorbital nerve; neuroregeneration; peripheral nerve injury; tacrolimus
المشرفين على المادة: WM0HAQ4WNM (Tacrolimus)
3IN71E75Z5 (Urethane)
0 (Amides)
0 (Carbamates)
8W8T17847W (Urea)
0 (Esters)
تواريخ الأحداث: Date Created: 20240123 Date Completed: 20240124 Latest Revision: 20240128
رمز التحديث: 20240128
مُعرف محوري في PubMed: PMC10815243
DOI: 10.3390/ijms25020847
PMID: 38255920
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25020847