دورية أكاديمية
أعرض في EDS

Parkinson's Disease Dementia Patients: Expression of Glia Maturation Factor in the Brain.

التفاصيل البيبلوغرافية
العنوان: Parkinson's Disease Dementia Patients: Expression of Glia Maturation Factor in the Brain.
المؤلفون: Thangavel R; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65212, USA., Kaur H; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65212, USA., Dubova I; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65212, USA., Selvakumar GP; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65212, USA., Ahmed ME; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65212, USA., Raikwar SP; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65212, USA., Govindarajan R; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65212, USA., Kempuraj D; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65212, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 18; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Dementia* , Encephalomyelitis, Autoimmune, Experimental* , Glia Maturation Factor*/genetics , Neurodegenerative Diseases* , Parkinson Disease*, Animals ; Humans ; Brain
مستخلص: Parkinson's disease (PD) is the second most common progressive neurodegenerative disease characterized by the presence of dopaminergic neuronal loss and motor disorders. PD dementia (PDD) is a cognitive disorder that affects many PD patients. We have previously demonstrated the proinflammatory role of the glia maturation factor (GMF) in neuroinflammation and neurodegeneration in AD, PD, traumatic brain injury (TBI), and experimental autoimmune encephalomyelitis (EAE) in human brains and animal models. The purpose of this study was to investigate the expression of the GMF in the human PDD brain. We analyzed the expression pattern of the GMF protein in conjunction with amyloid plaques (APs) and neurofibrillary tangles (NFTs) in the substantia nigra (SN) and striatum of PDD brains using immunostaining. We detected a large number of GMF-positive glial fibrillary acidic protein (GFAP) reactive astrocytes, especially abundant in areas with degenerating dopaminergic neurons within the SN and striatum in PDD. Additionally, we observed excess levels of GMF in glial cells in the vicinity of APs, and NFTs in the SN and striatum of PDD and non-PDD patients. We found that the majority of GMF-positive immunoreactive glial cells were co-localized with GFAP-reactive astrocytes. Our findings suggest that the GMF may be involved in the pathogenesis of PDD.
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فهرسة مساهمة: Keywords: Alzheimer’s disease; Parkinson’s disease dementia; amyloid plaques; dopaminergic neurons; glia maturation factor; glial fibrillary acidic protein; ionized calcium-binding adaptor molecule 1; neurofibrillary tangles; substantia nigra; tyrosine hydroxylase
المشرفين على المادة: 0 (Glia Maturation Factor)
تواريخ الأحداث: Date Created: 20240123 Date Completed: 20240124 Latest Revision: 20240608
رمز التحديث: 20240608
مُعرف محوري في PubMed: PMC11154259
DOI: 10.3390/ijms25021182
PMID: 38256254
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25021182