دورية أكاديمية
أعرض في EDS

Phytoconstituents and Ergosterol Biosynthesis-Targeting Antimicrobial Activity of Nutmeg ( Myristica fragans Houtt.) against Phytopathogens.

التفاصيل البيبلوغرافية
العنوان: Phytoconstituents and Ergosterol Biosynthesis-Targeting Antimicrobial Activity of Nutmeg ( Myristica fragans Houtt.) against Phytopathogens.
المؤلفون: Cruz A; Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.; Centre of Molecular and Environmental Biology (CBMA), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal., Sánchez-Hernández E; Department of Agricultural and Forestry Engineering, ETSIIAA, University of Valladolid, Avenida de Madrid 44, 34004 Palencia, Spain., Teixeira A; Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.; Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Trás-os-Montes and Alto Douro (UTAD), Quinta de Prados, 5000-801 Vila Real, Portugal., Oliveira R; Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.; Centre of Molecular and Environmental Biology (CBMA), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal., Cunha A; Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.; Centre of Molecular and Environmental Biology (CBMA), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal., Martín-Ramos P; Department of Agricultural and Forestry Engineering, ETSIIAA, University of Valladolid, Avenida de Madrid 44, 34004 Palencia, Spain.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Jan 18; Vol. 29 (2). Date of Electronic Publication: 2024 Jan 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Myristica*, Saccharomyces cerevisiae ; Crop Protection ; Ergosterol ; Plant Extracts
مستخلص: In recent years, nutmeg ( Myristica fragans Houtt.) has attracted considerable attention in the field of phytochemistry due to its diverse array of bioactive compounds. However, the potential application of nutmeg as a biorational for crop protection has been insufficiently explored. This study investigated the constituents of a nutmeg hydroethanolic extract via gas chromatography-mass spectrometry and vibrational spectroscopy. The research explored the extract's activity against phytopathogenic fungi and oomycetes, elucidating its mechanism of action. The phytochemical profile revealed fatty acids (including tetradecanoic acid, 9-octadecenoic acid, n -hexadecanoic acid, dodecanoic acid, and octadecanoic acid), methoxyeugenol, and elemicin as the main constituents. Previously unreported phytochemicals included veratone, gelsevirine, and montanine. Significant radial growth inhibition of mycelia was observed against Botrytis cinerea, Colletotrichum acutatum, Diplodia corticola, Phytophthora cinnamomi , and especially against Fusarium culmorum . Mode of action investigation, involving Saccharomyces cerevisiae labeled positively with propidium iodide, and a mutant strain affected in ERG6, encoding sterol C-24 methyltransferase, suggested that the extract induces a necrotic type of death and targets ergosterol biosynthesis. The evidence presented underscores the potential of nutmeg as a source of new antimicrobial agents, showing particular promise against F. culmorum .
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معلومات مُعتمدة: , under projects UIDB/04050/2020 and UIDB/04033/2020 FCT - Portuguese Foundation for Science and Technology; (NORTE-01-0145-FEDER-000041) AgrifoodXXI; project VA148P23, with FEDER co-funding Junta de Castilla y León under
فهرسة مساهمة: Keywords: Fusarium culmorum; Myristica fragans; biopesticide; indole alkaloids; phenylpropenes; plant extract
المشرفين على المادة: Z30RAY509F (Ergosterol)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20240123 Date Completed: 20240124 Latest Revision: 20240129
رمز التحديث: 20240129
مُعرف محوري في PubMed: PMC10819938
DOI: 10.3390/molecules29020471
PMID: 38257384
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules29020471