Chemical Characterization, Leishmanicidal Activity and In Vitro Cytotoxicity of the Essential Oil Extracted from Pectis brevipedunculata (Gardner) Sch.Bip. and Its Incorporation into Microemulsion Systems.

التفاصيل البيبلوغرافية
العنوان:	Chemical Characterization, Leishmanicidal Activity and In Vitro Cytotoxicity of the Essential Oil Extracted from Pectis brevipedunculata (Gardner) Sch.Bip. and Its Incorporation into Microemulsion Systems.
المؤلفون:	Lopes ACCB; Programa de Pós-Graduação em Biodiversidade e Biotecnologia da Rede BIONORTE (PPG-BIONORTE), Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil., do Nascimento JR; Programa de Pós-Graduação em Química, Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara 14800-060, SP, Brazil., Camara MBP; Programa de Pós-Graduação em Biodiversidade e Biotecnologia da Rede BIONORTE (PPG-BIONORTE), Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil., Lima ADS; Programa de Pós-Graduação em Química, Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil., Lopes GLN; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, Teresina 64049-550, PI, Brazil., do Nascimento MO; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, Teresina 64049-550, PI, Brazil., Xavier JKAM; Programa de Pós-Graduação em Química, Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil., de Jesus CM; Programa de Pós-Graduação em Saúde e Tecnologia, Universidade Federal do Maranhão, Imperatriz 65900-410, MA, Brazil., Mendonça CJS; Programa de Pós-Graduação em Química, Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil., Carvalho ALM; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, Teresina 64049-550, PI, Brazil., Silva LA; Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil., da Rocha CQ; Programa de Pós-Graduação em Biodiversidade e Biotecnologia da Rede BIONORTE (PPG-BIONORTE), Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil.; Programa de Pós-Graduação em Química, Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil.
المصدر:	Pharmaceutics [Pharmaceutics] 2024 Jan 09; Vol. 16 (1). Date of Electronic Publication: 2024 Jan 09.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Original Publication: Basel, Switzerland : MDPI
مستخلص:	Pectis brevipedunculata (Gardner) Sch.Bip., known in Brazil as alecrim do campo, is a small Asteraceae family plant with a calming effect and consumed as tea. This species contains components, such as neral and geranial, that display various biological activities, such as leishmanicidal. The aim was to chemically characterize the essential oil (EO) obtained from P. brevipedunculata (EO-PB) by hydrodistillation and a microemulsion formulated with EO (ME-PB), Tween 80 and Transcutol P, assess the leishmanicidal effect against Leishmania (L.) amazonensis promastigotes and cytotoxicity against RAW 264.7. EO-PB and ME-PB were analyzed by Gas Chromatography Mass Spectrometry (GC/MS). Monoterpene hydrocarbons were noteworthy among the identified compounds. The main EO-PB constituents were α-pinene and limonene, followed by neral and geranial, which were maintained in ME-PB. EO-PB presented an inhibitory concentration (IC 50 ) of 20 µg/mL and ME-PB of 0.93 µg/mL. ME-PB inhibition towards the parasite was 20-fold higher than that of EO-PB. This indicated that EO incorporation to the microemulsion resulted in optimized biological activity. Selectivity indices indicate that ME-PB is more selective concerning parasite inhibition. Thus, ME-PB may comprise an adequate approach against Leishmania, as the inhibitory concentration (IC 50 ) promastigotes was lower than that considered toxic for cells cell cytotoxicity of 50% (CC 50 ).
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معلومات مُعتمدة:	Finance code 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior; PROCAD-AM [88887.472618/2019-00 Coordenação de Aperfeicoamento de Pessoal de Nível Superior; INFRA-02263/21 Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão; 88881.691482/2022-01 CAPES/PDPG-POSDOC / Programa de Desenvolvimento da Pós-Graduação (PDPG) Pós-Doutorado Estratégico
فهرسة مساهمة:	Keywords: Asteraceae; L. (L.) amazonensis; formulation; monoterpenes; nanotechnology; promastigote
تواريخ الأحداث:	Date Created: 20240123 Latest Revision: 20240129
رمز التحديث:	20240129
مُعرف محوري في PubMed:	PMC10818420
DOI:	10.3390/pharmaceutics16010087
PMID:	38258098
قاعدة البيانات:	MEDLINE

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تدمد:	1999-4923
DOI:	10.3390/pharmaceutics16010087