دورية أكاديمية
Cholinergic modulation of rearing in rats performing a spatial memory task.
| العنوان: | Cholinergic modulation of rearing in rats performing a spatial memory task. |
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| المؤلفون: | Cassity S; Department of Psychological and Brain Sciences, College of Arts and Sciences, Indiana University Bloomington, Bloomington, Indiana, USA.; Program in Neuroscience, College of Arts and Sciences, Indiana University Bloomington, Bloomington, Indiana, USA., Choi IJ; Department of Psychological and Brain Sciences, College of Arts and Sciences, Indiana University Bloomington, Bloomington, Indiana, USA., Gregory BH; Department of Psychological and Brain Sciences, College of Arts and Sciences, Indiana University Bloomington, Bloomington, Indiana, USA., Igbasanmi AM; Department of Psychological and Brain Sciences, College of Arts and Sciences, Indiana University Bloomington, Bloomington, Indiana, USA., Bickford SC; Department of Psychological and Brain Sciences, College of Arts and Sciences, Indiana University Bloomington, Bloomington, Indiana, USA., Moore KT; Department of Psychological and Brain Sciences, College of Arts and Sciences, Indiana University Bloomington, Bloomington, Indiana, USA., Seraiah AE; Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA., Layfield D; Department of Psychological and Brain Sciences, College of Arts and Sciences, Indiana University Bloomington, Bloomington, Indiana, USA.; Intelligent Systems Engineering, Luddy School of Informatics Computing and Engineering, University Bloomington, Bloomington, Indiana, USA., Newman EL; Department of Psychological and Brain Sciences, College of Arts and Sciences, Indiana University Bloomington, Bloomington, Indiana, USA.; Intelligent Systems Engineering, Luddy School of Informatics Computing and Engineering, University Bloomington, Bloomington, Indiana, USA. |
| المصدر: | The European journal of neuroscience [Eur J Neurosci] 2024 May; Vol. 59 (9), pp. 2240-2255. Date of Electronic Publication: 2024 Jan 23. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-9568 (Electronic) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press, c1989- |
| مواضيع طبية MeSH: | Cholinergic Neurons*/physiology , Cholinergic Neurons*/drug effects , Cholinergic Neurons*/metabolism , Spatial Memory*/physiology , Spatial Memory*/drug effects , Optogenetics*/methods, Animals ; Male ; Rats ; Rats, Long-Evans ; Choline O-Acetyltransferase/metabolism ; Choline O-Acetyltransferase/genetics ; Acetylcholine/metabolism ; Memory, Short-Term/physiology ; Memory, Short-Term/drug effects ; Maze Learning/physiology ; Maze Learning/drug effects |
| مستخلص: | Spatial memory encoding depends in part on cholinergic modulation. How acetylcholine supports spatial memory encoding is not well understood. Prior studies indicate that acetylcholine release is correlated with exploration, including epochs of rearing onto hind legs. Here, to test whether elevated cholinergic tone increases the probability of rearing, we tracked rearing frequency and duration while optogenetically modulating the activity of choline acetyltransferase containing (i.e., acetylcholine producing) neurons of the medial septum in rats performing a spatial working memory task (n = 17 rats). The cholinergic neurons were optogenetically inhibited using halorhodopsin for the duration that rats occupied two of the four open arms during the study phase of an 8-arm radial arm maze win-shift task. Comparing rats' behaviour in the two arm types showed that rearing frequency was not changed, but the average duration of rearing epochs became significantly longer. This effect on rearing was observed during optogenetic inhibition but not during sham inhibition or in rats that received infusions of a fluorescent reporter virus (i.e., without halorhodopsin; n = 6 rats). Optogenetic inhibition of cholinergic neurons during the pretrial waiting phase had no significant effect on rearing, indicating a context-specificity of the observed effects. These results are significant in that they indicate that cholinergic neuron activity in the medial septum is correlated with rearing not because it motivates an exploratory state but because it contributes to the processing of information acquired while rearing. (© 2024 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.) |
| التعليقات: | Update of: bioRxiv. 2023 Dec 03;:. (PMID: 37873370) |
| References: | Behav Brain Res. 1985 Sep-Oct;17(2):103-15. (PMID: 4074488) J Neurosci. 2015 Jun 3;35(22):8394-410. (PMID: 26041909) Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17651-6. (PMID: 23045697) Front Neural Circuits. 2022 Aug 25;16:957441. (PMID: 36092276) Hippocampus. 2014 Jun;24(6):643-55. (PMID: 24493379) Neuron. 2011 Dec 8;72(5):721-33. (PMID: 22153370) Sci Rep. 2023 Apr 15;13(1):6136. (PMID: 37061540) Hippocampus. 2019 Nov;29(11):1075-1090. (PMID: 31095800) J Neurosci. 1994 Jun;14(6):3898-914. (PMID: 8207494) Hippocampus. 2017 Oct;27(10):1069-1082. (PMID: 28628945) Learn Mem. 2004 Jan-Feb;11(1):9-20. (PMID: 14747512) Curr Opin Neurobiol. 2006 Dec;16(6):710-5. (PMID: 17011181) Experientia. 1989 Sep 15;45(9):839-45. (PMID: 2570714) Neuroscience. 2004;126(3):541-57. (PMID: 15183504) J Exp Psychol Anim Behav Process. 2007 Jul;33(3):213-24. (PMID: 17620022) J Neurosci. 2013 Dec 11;33(50):19635-46. (PMID: 24336727) Brain Res. 1982 Mar;257(1):105-27. (PMID: 7059844) Netw Neurosci. 2017 Dec 01;1(4):339-356. (PMID: 30090870) Cell. 2010 Apr 2;141(1):154-165. (PMID: 20303157) Neuroscience. 2001;106(1):43-53. (PMID: 11564415) Front Behav Neurosci. 2012 Jun 13;6:24. (PMID: 22707936) Neuropsychologia. 2012 Nov;50(13):3156-68. (PMID: 22884957) Psychopharmacology (Berl). 1992;109(3):373-6. (PMID: 1365638) Eur J Neurosci. 2005 Sep;22(6):1349-56. (PMID: 16190890) Rev Neurosci. 2006;17(1-2):111-33. (PMID: 16703946) Nat Neurosci. 2018 Sep;21(9):1281-1289. (PMID: 30127430) J Neurosci. 2013 May 15;33(20):8689-704. (PMID: 23678113) J Neurosci. 1996 May 1;16(9):3089-96. (PMID: 8622138) Pharmacol Biochem Behav. 1997 Oct;58(2):577-82. (PMID: 9300622) Neuroscience. 1998 Aug;85(4):1253-62. (PMID: 9681961) Neuroscience. 1989;31(1):37-61. (PMID: 2475819) J Comp Neurol. 1985 Sep 8;239(2):237-46. (PMID: 4044938) Nat Protoc. 2019 Jul;14(7):2152-2176. (PMID: 31227823) Hippocampus. 2020 Feb;30(2):121-129. (PMID: 31453652) |
| معلومات مُعتمدة: | R01 AG076198 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Keywords: acetylcholine; exploration; hippocampus; medial septum; optogenetics; rat; rearing; reversible inactivation; spatial memory |
| المشرفين على المادة: | EC 2.3.1.6 (Choline O-Acetyltransferase) N9YNS0M02X (Acetylcholine) |
| تواريخ الأحداث: | Date Created: 20240123 Date Completed: 20240507 Latest Revision: 20240509 |
| رمز التحديث: | 20240509 |
| مُعرف محوري في PubMed: | PMC11076174 |
| DOI: | 10.1111/ejn.16248 |
| PMID: | 38258622 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1460-9568 |
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| DOI: | 10.1111/ejn.16248 |