دورية أكاديمية
أعرض في EDS

Tight junction proteins and biliary diseases.

التفاصيل البيبلوغرافية
العنوان: Tight junction proteins and biliary diseases.
المؤلفون: Merlen G; INSERM U1193, Université Paris-Saclay, bât Henri Moissan, 17 av. des Sciences, Orsay, France., Tordjmann T
المصدر: Current opinion in gastroenterology [Curr Opin Gastroenterol] 2024 Mar 01; Vol. 40 (2), pp. 70-76. Date of Electronic Publication: 2024 Jan 19.
نوع المنشور: Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8506887 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-7056 (Electronic) Linking ISSN: 02671379 NLM ISO Abbreviation: Curr Opin Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Publication: : Philadelphia, PA : Lippincott Williams & Wilkins
Original Publication: London ; New York : Gower Academic Journals, [1985-
مواضيع طبية MeSH: Tight Junction Proteins*/metabolism , Liver*/pathology, Humans ; Bile Ducts ; Tight Junctions/metabolism ; Tight Junctions/pathology ; Epithelial Cells
مستخلص: Purpose of Review: In the pathophysiological context of cholangiopathies and more broadly of hepatopathies, while it is conceptually clear that the maintenance of inter-cholangiocyte and inter-hepatocyte tight junction integrity would be crucial for liver protection, only scarce studies have been devoted to this topic. Indeed, in the liver, alteration of tight junctions, the intercellular adhesion complexes that control paracellular permeability would result in leaky bile ducts and bile canaliculi, allowing bile reflux towards hepatic parenchyma, contributing to injury during the disease process.
Recent Findings: Last decades have provided a great deal of information regarding both tight junction structural organization and signaling pathways related to tight junctions, providing clues about potential intervention to modulate paracellular permeability during cholangiopathies pathogenesis. Interestingly, several liver diseases have been reported to be associated with abnormal expression of one or several tight junction proteins. However, the question remains unanswered if these alterations would be primarily involved in the disease pathogenesis or if they would occur secondarily in the pathological course.
Summary: In this review, we provide an overview of tight junction disruptions described in various biliary diseases that should pave the way for defining new therapeutic targets in this field.
(Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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المشرفين على المادة: 0 (Tight Junction Proteins)
تواريخ الأحداث: Date Created: 20240123 Date Completed: 20240208 Latest Revision: 20240603
رمز التحديث: 20240603
DOI: 10.1097/MOG.0000000000000996
PMID: 38260939
قاعدة البيانات: MEDLINE
الوصف
تدمد:1531-7056
DOI:10.1097/MOG.0000000000000996