دورية أكاديمية
Maternal prenatal, with or without postpartum, vitamin D3 supplementation does not improve maternal iron status at delivery or infant iron status at 6 months of age: secondary analysis of a randomised controlled trial.
العنوان: | Maternal prenatal, with or without postpartum, vitamin D3 supplementation does not improve maternal iron status at delivery or infant iron status at 6 months of age: secondary analysis of a randomised controlled trial. |
---|---|
المؤلفون: | O'Callaghan KM; Department of Nutritional Sciences, King's College London, London, UK.; Centre for Global Child Health and SickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada., Qamar H; Centre for Global Child Health and SickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada., Gernand AD; Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA., Onoyovwi AK; Centre for Global Child Health and SickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada., Zlotkin S; Centre for Global Child Health and SickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Paediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada., Mahmud AA; Nutrition Research Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh., Ahmed T; Nutrition Research Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh., Keya FK; Nutrition Research Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh., Roth DE; Centre for Global Child Health and SickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Paediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada. |
المصدر: | BMJ nutrition, prevention & health [BMJ Nutr Prev Health] 2023 Dec; Vol. 6 (2), pp. 282-292. Date of Electronic Publication: 2023 Nov 14. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BMJ in association with the NNEdPro Global Centre for Nutrition and Health (Cambridge) Country of Publication: England NLM ID: 101769223 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2516-5542 (Electronic) Linking ISSN: 25165542 NLM ISO Abbreviation: BMJ Nutr Prev Health Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : BMJ in association with the NNEdPro Global Centre for Nutrition and Health (Cambridge), [2018]- |
مستخلص: | Background: Vitamin D may modify iron status through regulation of hepcidin and inflammatory pathways. This study aimed to investigate effects of maternal vitamin D supplementation on iron status in pregnancy and early infancy. Methods: In a trial in Dhaka, Bangladesh, women (n=1300) were randomised to one of five vitamin D Results: At delivery, ferritin concentrations were similar between each intervention group and placebo in unadjusted (n=998) and baseline ferritin-adjusted analyses (n=992; p>0.05). Compared with placebo, AGP was lower in each intervention group (per cent difference (95% CI) = -11% (-21 to -1.0), -14% (-23 to -3.5) and -11% (-19 to -2.0) in the 4200 IU/week, 16 800 IU/week and 28 000 IU/week groups, respectively; n=779). In the subgroup of women with baseline 25-hydroxyvitamin D < 30 nmol/L, ferritin was lower in each intervention group versus placebo (-23% (-37 to -5.0), -20% (-35 to -1.9) and -20% (-33 to -4.1) in the 4200 IU/week, 16 800 IU/week and 28 000 IU/week groups, respectively; n=645); effects were slightly attenuated after adjustment for inflammation (n=510). There were no effects of vitamin D on other iron biomarkers among women at delivery or infants aged 6 months. Conclusion: These findings do not support improvement of iron status by vitamin D. The effect of prenatal vitamin D supplementation on ferritin may reflect an anti-inflammatory mechanism. Competing Interests: Competing interests: None declared (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.) |
References: | Lancet Glob Health. 2022 Nov;10(11):e1590-e1599. (PMID: 36240826) Am J Clin Nutr. 2006 Apr;83(4):788-94. (PMID: 16600929) J Am Soc Nephrol. 2014 Mar;25(3):564-72. (PMID: 24204002) N Engl J Med. 2018 Nov 08;379(19):1881. (PMID: 30403950) Nutrients. 2018 Jan 31;10(2):. (PMID: 29385099) Matern Child Nutr. 2016 Oct;12(4):647-68. (PMID: 26373311) Am J Physiol Gastrointest Liver Physiol. 2006 Feb;290(2):G199-203. (PMID: 16407589) Pediatr Nephrol. 2013 Aug;28(8):1261-6. (PMID: 23420502) BMJ Open. 2020 Jan 20;10(1):e032626. (PMID: 31964667) Lancet Glob Health. 2013 Jul;1(1):e16-25. (PMID: 25103581) Physiol Rev. 2016 Jan;96(1):365-408. (PMID: 26681795) Public Health Nutr. 2020 May;23(7):1208-1213. (PMID: 31097054) J Nephrol. 2011 Jan-Feb;24(1):98-105. (PMID: 20563998) Am J Clin Nutr. 2015 Nov;102(5):1088-95. (PMID: 26447159) Trials. 2015 Jul 14;16:300. (PMID: 26169781) BJOG. 2013 Sep;120 Suppl 2:42-7, v. (PMID: 23841804) Clin Nutr. 2017 Aug;36(4):980-985. (PMID: 27402475) J Clin Transl Endocrinol. 2014 Mar 21;1(1):19-25. (PMID: 25097830) Nutr J. 2016 Aug 09;15(1):74. (PMID: 27506667) Am J Clin Nutr. 2017 Dec;106(Suppl 6):1606S-1614S. (PMID: 29070545) Exp Hematol. 2002 May;30(5):403-9. (PMID: 12031646) Nutrients. 2022 Mar 25;14(7):. (PMID: 35405984) PLoS One. 2022 Nov 30;17(11):e0278350. (PMID: 36449486) Nutrients. 2019 Jan 18;11(1):. (PMID: 30669280) Neonatology. 2007;92(2):73-82. (PMID: 17361090) Am J Clin Nutr. 2017 Jul;106(Suppl 1):333S-347S. (PMID: 28615254) Eur J Clin Nutr. 2017 Aug;71(8):931-943. (PMID: 28488684) |
فهرسة مساهمة: | Keywords: Nutrient deficiencies |
تواريخ الأحداث: | Date Created: 20240124 Latest Revision: 20240425 |
رمز التحديث: | 20240425 |
مُعرف محوري في PubMed: | PMC10800272 |
DOI: | 10.1136/bmjnph-2023-000758 |
PMID: | 38264359 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2516-5542 |
---|---|
DOI: | 10.1136/bmjnph-2023-000758 |