دورية أكاديمية
Anti-inflammatory, analgesic, antitussive and antipyretic activities of polyphenol-enriched fraction from Nymphaea candida.
| العنوان: | Anti-inflammatory, analgesic, antitussive and antipyretic activities of polyphenol-enriched fraction from Nymphaea candida. |
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| المؤلفون: | Sun Y; School of Pharmacy, Xinjiang Medical University, Urumqi, 830011, China. Electronic address: 562963262@qq.com., Qi Z; School of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, 830011, China. Electronic address: bright674511@yeah.net., Xu Y; School of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, 830011, China. Electronic address: xuyuanhui1999@163.com., Li C; Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi, 830004, China. Electronic address: licy0609@126.com., Zhao J; School of Pharmacy, Xinjiang Medical University, Urumqi, 830011, China; Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi, 830004, China. Electronic address: zhaojun21cn@163.com., Liu T; School of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, 830011, China. Electronic address: xjmult@163.com. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2024 Apr 24; Vol. 324, pp. 117789. Date of Electronic Publication: 2024 Jan 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Antipyretics*/pharmacology , Antipyretics*/therapeutic use , Antipyretics*/chemistry , Nymphaea* , Antitussive Agents*/therapeutic use, Rats ; Mice ; Animals ; Carrageenan ; Polyphenols/pharmacology ; Polyphenols/therapeutic use ; Tumor Necrosis Factor-alpha ; Saccharomyces cerevisiae ; Interleukin-6 ; Cyclooxygenase 2 ; Dinoprostone ; Plant Extracts/therapeutic use ; Plant Extracts/toxicity ; Anti-Inflammatory Agents/adverse effects ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Analgesics/chemistry ; Pain/drug therapy ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Edema/chemically induced ; Edema/drug therapy ; Edema/pathology ; Acetates ; Cough/drug therapy ; Granuloma/drug therapy ; Superoxide Dismutase |
| مستخلص: | Ethnopharmacological Relevance: "Snow-white waterlily" (Nymphaea candida) dried flower possesses various efficacy in Uighur medicine such as reducing fever and nourishing the liver, anti-inflammatory and cough relieving, moistening the throat and quenching thirst. Aim of the Study: Polyphenols are characteristic component of N. candida as well as its quality markers, and the purpose of this study was to conduct investigations into anti-inflammatory, antitussive, antipyretic, and analgesic activities of the polyphenol-enriched fraction from N. candida (NCTP) in order to validate the traditional efficacy of this plant. Materials and Methods: The polyphenols in NCTP were analyzed by HPLC, and an acute oral toxicity study was conducted for NCTP. The anti-inflammatory activities of NCTP were evaluated using xylene induced ear edema, capillary permeability, cotton pellet granuloma, and carrageenan-induced rat paw edema, of which multiple biochemical indices were measured in carrageenan-induced rat paw edema such as prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2),5-lipoxygenase (5-LOX), interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) activities; the analgesic activities were investigated using acetic acid writhing, hot plate test, and formalin test; the anti-tussive and antipyretic effects were tested by ammonia induced cough in mice and yeast-induced fever respectively. Results: NCTP with LD50 of 5222 mg/kg was low toxicity and safety. NCTP (200 mg/kg) could significantly reduce ear swelling and capillary permeability by 30.63% and 31.37%, respectively. NCTP revealed 15.76% inhibiting activities in cotton pellet granuloma in mice at a dosage of 200 mg/kg. Furthermore, NCTP (50, 100, and 200 mg/kg) substantially decreased carrageenin-induced paw edema in rats between 1 and 5 h, and NCTP could decrease PGE2, 5-LOX, COX-2 levels as well as IL-6, IL-1β, TNF-α activities compared with the control group; NCTP could decrease MDA contents in carrageenin-induced rise, and increase SOD and GSH activities. Furthermore, the dose-dependent inhibition effect of NCTP on pain was revealed in the hot plate experiment. In addition to reducing the amount of writhes brought on by acetic acid, NCTP (50, 100, and 200 mg/kg) significantly inhibited pain latency against both stages of the formalin test. Moreover, NCTP (50, 100, 200 mg/kg) showed the better antitussive activities in mice in a dose-dependent manner. In the yeast-induced pyrexia test, dosages of 50, 100, and 200 mg/kg resulted in a statistically significant drop in rectal temperature. Conclusion: The experimental results proved the analgesic, anti-inflammatory, anti-tussive and antipyretic activities of the polyphenol-enriched fraction from N. candida, and supported the traditional use of this plant as well. Competing Interests: Declaration of competing interest All authors disclosed no relevant relationships, and confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. (Copyright © 2024. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Analgesic; Anti-inflammatory; Anti-pyretic; Anti-tussive; Nymphaea candida; Polyphenols |
| المشرفين على المادة: | 0 (Antipyretics) 9000-07-1 (Carrageenan) 0 (Antitussive Agents) 0 (Polyphenols) 0 (Tumor Necrosis Factor-alpha) 0 (Interleukin-6) EC 1.14.99.1 (Cyclooxygenase 2) K7Q1JQR04M (Dinoprostone) 0 (Plant Extracts) 0 (Anti-Inflammatory Agents) 0 (Analgesics) 0 (Anti-Inflammatory Agents, Non-Steroidal) 0 (Acetates) EC 1.15.1.1 (Superoxide Dismutase) |
| تواريخ الأحداث: | Date Created: 20240124 Date Completed: 20240214 Latest Revision: 20240214 |
| رمز التحديث: | 20240214 |
| DOI: | 10.1016/j.jep.2024.117789 |
| PMID: | 38266950 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2024.117789 |