دورية أكاديمية
p40 homodimers bridge ischemic tissue inflammation and heterologous alloimmunity in mice via IL-15 transpresentation.
العنوان: | p40 homodimers bridge ischemic tissue inflammation and heterologous alloimmunity in mice via IL-15 transpresentation. |
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المؤلفون: | Tsuda H; Department of Inflammation & Immunity, Lerner Research Institute, Cleveland, Ohio, USA.; Transplant Center, Cleveland Clinic, Cleveland, Ohio, USA., Keslar KS; Department of Inflammation & Immunity, Lerner Research Institute, Cleveland, Ohio, USA.; Transplant Center, Cleveland Clinic, Cleveland, Ohio, USA., Baldwin WM 3rd; Department of Inflammation & Immunity, Lerner Research Institute, Cleveland, Ohio, USA.; Transplant Center, Cleveland Clinic, Cleveland, Ohio, USA., Heeger PS; Icahn School of Medicine at Mount Sinai, New York, New York, USA., Valujskikh A; Department of Inflammation & Immunity, Lerner Research Institute, Cleveland, Ohio, USA.; Transplant Center, Cleveland Clinic, Cleveland, Ohio, USA., Fairchild RL; Department of Inflammation & Immunity, Lerner Research Institute, Cleveland, Ohio, USA.; Transplant Center, Cleveland Clinic, Cleveland, Ohio, USA. |
المصدر: | The Journal of clinical investigation [J Clin Invest] 2024 Jan 25; Vol. 134 (6). Date of Electronic Publication: 2024 Jan 25. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation Original Publication: New Haven [etc.] American Society for Clinical Investigation. |
مواضيع طبية MeSH: | Heart Transplantation* , Interleukin-15*/genetics, Animals ; Mice ; CD8-Positive T-Lymphocytes ; Graft Rejection ; Immunologic Memory ; Mice, Inbred C57BL ; Transplantation, Homologous ; Interleukin-9/metabolism |
مستخلص: | Virus-induced memory T cells often express functional cross-reactivity, or heterologous immunity, to other viruses and to allogeneic MHC molecules that is an important component of pathogenic responses to allogeneic transplants. During immune responses, antigen-reactive naive and central memory T cells proliferate in secondary lymphoid organs to achieve sufficient cell numbers to effectively respond, whereas effector memory T cell proliferation occurs directly within the peripheral inflammatory microenvironment. Mechanisms driving heterologous memory T cell proliferation and effector function expression within peripheral tissues remain poorly understood. Here, we dissected proliferation of heterologous donor-reactive memory CD8+ T cells and their effector functions following infiltration into heart allografts with low or high intensities of ischemic inflammation. Proliferation within both ischemic conditions required p40 homodimer-induced IL-15 transpresentation by graft DCs, but expression of effector functions mediating acute allograft injury occurred only in high-ischemic allografts. Transcriptional responses of heterologous donor-reactive memory CD8+ T cells were distinct from donor antigen-primed memory CD8+ T cells during early activation in allografts and at graft rejection. Overall, the results provide insights into mechanisms driving heterologous effector memory CD8+ T cell proliferation and the separation between proliferation and effector function that is dependent on the intensity of inflammation within the tissue microenvironment. |
References: | Immunity. 2022 Jun 14;55(6):1032-1050.e14. (PMID: 35704993) J Exp Med. 2001 Oct 15;194(8):1187-94. (PMID: 11602647) Am J Pathol. 2004 Mar;164(3):807-15. (PMID: 14982835) JCI Insight. 2018 Feb 22;3(4):. (PMID: 29467328) Kidney Int. 2015 Feb;87(2):343-9. (PMID: 25229341) JCI Insight. 2021 Dec 22;6(24):. (PMID: 34752416) J Exp Med. 2002 Jun 17;195(12):1515-22. (PMID: 12070279) Am J Transplant. 2013 May;13(5):1134-48. (PMID: 23566221) J Immunol. 2012 Mar 15;188(6):2483-7. (PMID: 22327071) J Exp Med. 1994 Jun 1;179(6):1933-43. (PMID: 8195718) Trends Immunol. 2007 Jan;28(1):33-8. (PMID: 17126601) Nephrol Dial Transplant. 2009 Mar;24(3):1039-47. (PMID: 19103734) J Exp Med. 2002 Jun 17;195(12):1541-8. (PMID: 12070282) Am J Transplant. 2013 Sep;13(9):2293-307. (PMID: 23914930) Am J Physiol Renal Physiol. 2008 Nov;295(5):F1414-21. (PMID: 18753296) J Clin Invest. 2003 Jun;111(12):1887-95. (PMID: 12813024) J Exp Med. 1994 Apr 1;179(4):1155-61. (PMID: 7511682) J Immunol. 2001 Aug 1;167(3):1179-87. (PMID: 11466332) Am J Transplant. 2014 Mar;14(3):568-79. (PMID: 24502272) PLoS One. 2018 Jul 30;13(7):e0200696. (PMID: 30059561) Science. 1996 Jun 28;272(5270):1947-50. (PMID: 8658169) Am J Transplant. 2020 Aug;20(8):2206-2215. (PMID: 32154641) Immunity. 2022 Mar 8;55(3):475-493.e5. (PMID: 35216666) Nature. 1999 Oct 14;401(6754):708-12. (PMID: 10537110) Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19454-9. (PMID: 17159138) J Immunol. 2003 Apr 15;170(8):4077-86. (PMID: 12682237) J Immunol. 2015 Jun 15;194(12):6045-56. (PMID: 25964490) Blood. 2010 Apr 15;115(15):3146-57. (PMID: 20160165) J Immunol. 1999 Aug 15;163(4):2267-75. (PMID: 10438971) J Exp Med. 2000 Dec 18;192(12):1685-96. (PMID: 11120766) Am J Transplant. 2005 Aug;5(8):1971-5. (PMID: 15996247) Immunity. 1996 Apr;4(4):329-36. (PMID: 8612127) Transplantation. 2004 Dec 15;78(11):1640-6. (PMID: 15591953) Eur J Immunol. 2000 Feb;30(2):392-402. (PMID: 10671194) Immunol Rev. 2006 Jun;211:164-81. (PMID: 16824126) Science. 2008 Nov 14;322(5904):1097-100. (PMID: 19008445) J Am Soc Nephrol. 2008 Jul;19(7):1419-29. (PMID: 18417724) Transplantation. 1973 Oct;16(4):343-50. (PMID: 4583148) J Am Soc Nephrol. 2006 Feb;17(2):564-72. (PMID: 16382020) J Exp Med. 2006 Jul 10;203(7):1805-15. (PMID: 16818672) Annu Rev Immunol. 2013;31:137-61. (PMID: 23215646) J Exp Med. 2004 Oct 4;200(7):825-34. (PMID: 15452177) Am J Transplant. 2008 Aug;8(8):1652-61. (PMID: 18557725) J Neurochem. 2003 Jul;86(2):519-28. (PMID: 12871593) J Clin Invest. 2018 Oct 1;128(10):4557-4572. (PMID: 30222140) Eur J Immunol. 1999 Jun;29(6):2007-13. (PMID: 10382764) J Immunol. 2004 May 1;172(9):5456-66. (PMID: 15100287) J Immunol. 2008 Oct 15;181(8):5560-7. (PMID: 18832714) J Clin Invest. 2020 Jul 1;130(7):3437-3452. (PMID: 32191642) Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):599-608. (PMID: 30587590) Nat Immunol. 2003 Mar;4(3):225-34. (PMID: 12563257) Immunity. 2013 Jan 24;38(1):131-9. (PMID: 23260193) J Immunol. 2013 Mar 1;190(5):1936-47. (PMID: 23355737) PLoS One. 2015 Mar 10;10(3):e0120274. (PMID: 25756182) Mucosal Immunol. 2017 Jul;10(4):1031-1042. (PMID: 27924822) J Exp Med. 2002 May 20;195(10):1289-302. (PMID: 12021309) Science. 1996 Apr 5;272(5258):60-6. (PMID: 8600538) Am J Transplant. 2009 Sep;9(9):2057-66. (PMID: 19624567) Am J Transplant. 2015 Dec;15(12):3081-94. (PMID: 26228897) J Exp Med. 1996 Jun 1;183(6):2489-99. (PMID: 8676069) |
معلومات مُعتمدة: | R01 AI040459 United States AI NIAID NIH HHS; R01 AI113142 United States AI NIAID NIH HHS; U01 AI063594 United States AI NIAID NIH HHS |
فهرسة مساهمة: | Keywords: Adaptive immunity; Innate immunity; Organ transplantation; Transplantation |
المشرفين على المادة: | 0 (Interleukin-15) 0 (Interleukin-9) |
تواريخ الأحداث: | Date Created: 20240125 Date Completed: 20240318 Latest Revision: 20240319 |
رمز التحديث: | 20240319 |
مُعرف محوري في PubMed: | PMC10940089 |
DOI: | 10.1172/JCI172760 |
PMID: | 38271093 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1558-8238 |
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DOI: | 10.1172/JCI172760 |