دورية أكاديمية
أعرض في EDS

p40 homodimers bridge ischemic tissue inflammation and heterologous alloimmunity in mice via IL-15 transpresentation.

التفاصيل البيبلوغرافية
العنوان: p40 homodimers bridge ischemic tissue inflammation and heterologous alloimmunity in mice via IL-15 transpresentation.
المؤلفون: Tsuda H; Department of Inflammation & Immunity, Lerner Research Institute, Cleveland, Ohio, USA.; Transplant Center, Cleveland Clinic, Cleveland, Ohio, USA., Keslar KS; Department of Inflammation & Immunity, Lerner Research Institute, Cleveland, Ohio, USA.; Transplant Center, Cleveland Clinic, Cleveland, Ohio, USA., Baldwin WM 3rd; Department of Inflammation & Immunity, Lerner Research Institute, Cleveland, Ohio, USA.; Transplant Center, Cleveland Clinic, Cleveland, Ohio, USA., Heeger PS; Icahn School of Medicine at Mount Sinai, New York, New York, USA., Valujskikh A; Department of Inflammation & Immunity, Lerner Research Institute, Cleveland, Ohio, USA.; Transplant Center, Cleveland Clinic, Cleveland, Ohio, USA., Fairchild RL; Department of Inflammation & Immunity, Lerner Research Institute, Cleveland, Ohio, USA.; Transplant Center, Cleveland Clinic, Cleveland, Ohio, USA.
المصدر: The Journal of clinical investigation [J Clin Invest] 2024 Jan 25; Vol. 134 (6). Date of Electronic Publication: 2024 Jan 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation
Original Publication: New Haven [etc.] American Society for Clinical Investigation.
مواضيع طبية MeSH: Heart Transplantation* , Interleukin-15*/genetics, Animals ; Mice ; CD8-Positive T-Lymphocytes ; Graft Rejection ; Immunologic Memory ; Mice, Inbred C57BL ; Transplantation, Homologous ; Interleukin-9/metabolism
مستخلص: Virus-induced memory T cells often express functional cross-reactivity, or heterologous immunity, to other viruses and to allogeneic MHC molecules that is an important component of pathogenic responses to allogeneic transplants. During immune responses, antigen-reactive naive and central memory T cells proliferate in secondary lymphoid organs to achieve sufficient cell numbers to effectively respond, whereas effector memory T cell proliferation occurs directly within the peripheral inflammatory microenvironment. Mechanisms driving heterologous memory T cell proliferation and effector function expression within peripheral tissues remain poorly understood. Here, we dissected proliferation of heterologous donor-reactive memory CD8+ T cells and their effector functions following infiltration into heart allografts with low or high intensities of ischemic inflammation. Proliferation within both ischemic conditions required p40 homodimer-induced IL-15 transpresentation by graft DCs, but expression of effector functions mediating acute allograft injury occurred only in high-ischemic allografts. Transcriptional responses of heterologous donor-reactive memory CD8+ T cells were distinct from donor antigen-primed memory CD8+ T cells during early activation in allografts and at graft rejection. Overall, the results provide insights into mechanisms driving heterologous effector memory CD8+ T cell proliferation and the separation between proliferation and effector function that is dependent on the intensity of inflammation within the tissue microenvironment.
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معلومات مُعتمدة: R01 AI040459 United States AI NIAID NIH HHS; R01 AI113142 United States AI NIAID NIH HHS; U01 AI063594 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Adaptive immunity; Innate immunity; Organ transplantation; Transplantation
المشرفين على المادة: 0 (Interleukin-15)
0 (Interleukin-9)
تواريخ الأحداث: Date Created: 20240125 Date Completed: 20240318 Latest Revision: 20240319
رمز التحديث: 20240319
مُعرف محوري في PubMed: PMC10940089
DOI: 10.1172/JCI172760
PMID: 38271093
قاعدة البيانات: MEDLINE
الوصف
تدمد:1558-8238
DOI:10.1172/JCI172760