دورية أكاديمية
أعرض في EDS

Oxidative DNA damage: Induction by fructose, in vitro, and its enhancement by hydrogen peroxide.

التفاصيل البيبلوغرافية
العنوان: Oxidative DNA damage: Induction by fructose, in vitro, and its enhancement by hydrogen peroxide.
المؤلفون: Midorikawa K; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, Japan; Faculty of Child Education, Suzuka University, 663-222, Koriyama, Suzuka, Mie 510-0298, Japan., Kobayashi K; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, Japan., Kato S; Radioisotope Experimental Facility, Advanced Science Research Promotion Center, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan., Kawanishi S; Faculty of Pharmaceutical Science, Suzuka University of Medical Science, 3500-3, Minamitamagaki, Suzuka, Mie 513-8670, Japan., Kobayashi H; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, Japan., Oikawa S; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, Japan., Murata M; Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, Japan. Electronic address: mmurata@med.mie-u.ac.jp.
المصدر: Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2024 Jan; Vol. 893, pp. 503719. Date of Electronic Publication: 2023 Nov 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101632149 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3592 (Electronic) Linking ISSN: 13835718 NLM ISO Abbreviation: Mutat Res Genet Toxicol Environ Mutagen Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier, 1997-
مواضيع طبية MeSH: Deoxyguanosine* , Hydrogen Peroxide*/toxicity, Humans ; 8-Hydroxy-2'-Deoxyguanosine ; Oxidative Stress ; DNA Damage ; Glucose ; Copper/pharmacology ; Oxidation-Reduction
مستخلص: Sucrose and high-fructose corn syrup comprise nearly equal amounts of glucose and fructose. With the use of high-fructose corn syrup in the food industry, consumption of fructose, which may be a tumor promoter, has increased dramatically. We examined fructose-induced oxidative DNA damage in the presence of Cu(II), with or without the addition of H 2 O 2 . With isolated DNA, fructose induced Cu(II)-mediated DNA damage, including formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), to a greater extent than did glucose, and H 2 O 2 enhanced the damage. In cultured human cells, 8-oxodG formation increased significantly following treatment with fructose and the H 2 O 2 -generating enzyme glucose oxidase. Fructose may play an important role in oxidative DNA damage, suggesting a possible mechanism for involvement of fructose in carcinogenesis.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Copper; Oxidative stress; Reactive oxygen species; Redox cycling; Sugar
المشرفين على المادة: 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
G9481N71RO (Deoxyguanosine)
BBX060AN9V (Hydrogen Peroxide)
IY9XDZ35W2 (Glucose)
789U1901C5 (Copper)
تواريخ الأحداث: Date Created: 20240125 Date Completed: 20240129 Latest Revision: 20240129
رمز التحديث: 20240129
DOI: 10.1016/j.mrgentox.2023.503719
PMID: 38272630
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-3592
DOI:10.1016/j.mrgentox.2023.503719