دورية أكاديمية
Relevance of sarcopenia in elderly patients undergoing surgery for oral squamous cell carcinoma.
| العنوان: | Relevance of sarcopenia in elderly patients undergoing surgery for oral squamous cell carcinoma. |
|---|---|
| المؤلفون: | Madadian MA; Regional Maxillofacial Unit, Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital, Lower Lane, Fazakerley, Liverpool L9 7AL, UK., Da Costa LS; Regional Maxillofacial Unit, Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital, Lower Lane, Fazakerley, Liverpool L9 7AL, UK., Kerai A; Regional Maxillofacial Unit, Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital, Lower Lane, Fazakerley, Liverpool L9 7AL, UK., Bajwa MS; Regional Maxillofacial Unit, Liverpool University Hospitals NHS Foundation Trust, Aintree University Hospital, Lower Lane, Fazakerley, Liverpool L9 7AL, UK. Electronic address: mbajwa@liverpool.ac.uk., Rogers SN; Maxillofacial Department, Wirral University Teaching Hospital NHS Foundation Trust, Arrowe Park Hospital, Arrowe Park Rd, Birkenhead, Wirral CH49 5PE, UK. |
| المصدر: | The British journal of oral & maxillofacial surgery [Br J Oral Maxillofac Surg] 2024 Feb; Vol. 62 (2), pp. 184-190. Date of Electronic Publication: 2023 Dec 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 8405235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1940 (Electronic) Linking ISSN: 02664356 NLM ISO Abbreviation: Br J Oral Maxillofac Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Edinburgh, U.K. : Churchill Livingstone, c1984- |
| مواضيع طبية MeSH: | Sarcopenia*/complications , Sarcopenia*/diagnosis , Sarcopenia*/epidemiology , Carcinoma, Squamous Cell*/surgery , Carcinoma, Squamous Cell*/complications , Frailty*/complications , Frailty*/diagnosis , Mouth Neoplasms*/surgery , Mouth Neoplasms*/complications , Head and Neck Neoplasms*/complications, Humans ; Aged ; Squamous Cell Carcinoma of Head and Neck/complications ; Retrospective Studies ; Cohort Studies |
| مستخلص: | In the elderly population there is increasing evidence that frailty predicts adverse outcomes better than chronological age. Sarcopenia is an important component of frailty. This study aimed to establish the relevance of sarcopenia in elderly patients with oral squamous cell carcinoma (OSCC) undergoing surgery. This retrospective, single-centre, cohort study included patients over the age of 75 years who were diagnosed with OSCC between 2007 and 2016. Cross-sectional imaging of the neck was used to predict the Skeletal Muscle Index (SMI) using validated equations. Based on established thresholds, patients were categorised as having either a normal or low SMI, indicative of sarcopenia. Sixty-nine patients met the inclusion criteria. Patients with a low SMI had a longer length of stay (16.9 days vs 9.8 days, p = 0.030); they had more severe complications, defined as Clavien-Dindo grade IIIb or higher (17.6% vs 4.0%, p = 0.042); and their mean Comprehensive Complication Index (CCI) was also higher (14.1 vs 4.7, p = 0.051). Furthermore, 2/34 patients in the low SMI group died within 30 days of surgery compared with none in the normal SMI group (5.9% vs 0%, p = 0.503). Whilst patients with a low SMI who underwent surgery had lower five-year overall survival, the difference was not statistically significant. This study shows that sarcopenia negatively influences surgical outcomes in elderly patients. Routine measurement of SMI could be an indication for a comprehensive geriatric assessment (CGA). (Crown Copyright © 2023. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Frailty; Mouth neoplasms; Sarcopenia; Squamous cell carcinoma of head and neck; Surgical oncology |
| تواريخ الأحداث: | Date Created: 20240125 Date Completed: 20240304 Latest Revision: 20240304 |
| رمز التحديث: | 20240304 |
| DOI: | 10.1016/j.bjoms.2023.11.017 |
| PMID: | 38272707 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-1940 |
|---|---|
| DOI: | 10.1016/j.bjoms.2023.11.017 |