دورية أكاديمية
Clinical and molecular epidemiology of enterovirus D68 from 2013 to 2020 in Shanghai.
| العنوان: | Clinical and molecular epidemiology of enterovirus D68 from 2013 to 2020 in Shanghai. |
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| المؤلفون: | Li F; Infectious Disease Department, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China., Lu RJ; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China., Zhang YH; Infectious Disease Department, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China., Shi P; Statistics and Data Management Center, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China., Ao YY; Virology Department, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China., Cao LF; Virology Department, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China., Zhang YL; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China., Tan WJ; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China. tanwj28@163.com., Shen J; Infectious Disease Department, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. shenjun_@fudan.edu.cn. |
| المصدر: | Scientific reports [Sci Rep] 2024 Jan 25; Vol. 14 (1), pp. 2161. Date of Electronic Publication: 2024 Jan 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Enterovirus D, Human*/genetics , Respiratory Tract Infections*/epidemiology , Enterovirus Infections*/epidemiology , Enterovirus*/genetics, Child ; Humans ; Molecular Epidemiology ; Phylogeny ; China/epidemiology ; Disease Outbreaks |
| مستخلص: | Enterovirus D68 (EV-D68) is an emerging pathogen that has caused outbreaks of severe respiratory disease worldwide, especially in children. We aim to investigate the prevalence and genetic characteristics of EV-D68 in children from Shanghai. Nasopharyngeal swab or bronchoalveolar lavage fluid samples collected from children hospitalized with community-acquired pneumonia were screened for EV-D68. Nine of 3997 samples were EV-D68-positive. Seven of nine positive samples were sequenced and submitted to GenBank. Based on partial polyprotein gene (3D) or complete sequence analysis, we found the seven strains belong to different clades and subclades, including three D1 (detected in 2013 and 2014), one D2 (2013), one D3 (2019), and two B3 (2014 and 2018). Overall, we show different clades and subclades of EV-D68 spread with low positive rates (0.2%) among children in Shanghai between 2013 and 2020. Amino acid mutations were found in the epitopes of the VP1 BC and DE loops and C-terminus; similarity analysis provided evidence for recombination as an important mechanism of genomic diversification. Both single nucleotide mutations and recombination play a role in evolution of EV-D68. Genetic instability within these clinical strains may indicate large outbreaks could occur following cumulative mutations. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | 19411972100 Shanghai Science and Technology Commission Medical Project; EK2022ZX05 Key Development Program of Children's Hospital of Fudan University |
| تواريخ الأحداث: | Date Created: 20240125 Date Completed: 20240129 Latest Revision: 20240129 |
| رمز التحديث: | 20240129 |
| مُعرف محوري في PubMed: | PMC10810781 |
| DOI: | 10.1038/s41598-024-52226-w |
| PMID: | 38272942 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-2322 |
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| DOI: | 10.1038/s41598-024-52226-w |