دورية أكاديمية
أعرض في EDS

Differential gene expression and microRNA profile in corpora allata-corpora cardiaca of Aedes aegypti mosquitoes with weak juvenile hormone signalling.

التفاصيل البيبلوغرافية
العنوان: Differential gene expression and microRNA profile in corpora allata-corpora cardiaca of Aedes aegypti mosquitoes with weak juvenile hormone signalling.
المؤلفون: Qi Z; Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD, Australia., Etebari K; Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD, Australia., Nouzova M; Institute of Parasitology, Biology Centre CAS, České Budějovice, Czech Republic., Noriega FG; Department of Biological Sciences and Biomolecular Sciences Institute, Florida International University, Miami, FL, USA.; Department of Parasitology, University of South Bohemia, České Budějovice, Czech Republic., Asgari S; Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD, Australia. s.asgari@uq.edu.au.
المصدر: BMC genomics [BMC Genomics] 2024 Jan 25; Vol. 25 (1), pp. 113. Date of Electronic Publication: 2024 Jan 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164 (Electronic) Linking ISSN: 14712164 NLM ISO Abbreviation: BMC Genomics Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2000-
مواضيع طبية MeSH: Aedes*/genetics , Aedes*/metabolism , MicroRNAs*/genetics , MicroRNAs*/metabolism, Animals ; Female ; Juvenile Hormones/metabolism ; Corpora Allata/metabolism ; Gene Expression
مستخلص: The corpora allata-corpora cardiaca (CA-CC) is an endocrine gland complex that regulates mosquito development and reproduction through the synthesis of juvenile hormone (JH). Epoxidase (Epox) is a key enzyme in the production of JH. We recently utilized CRISPR/Cas9 to establish an epoxidase-deficient (epox -/- ) Aedes aegypti line. The CA from epox -/- mutants do not synthesize epoxidated JH III but methyl farneosate (MF), a weak agonist of the JH receptor, and therefore have reduced JH signalling. Illumina sequencing was used to examine the differences in gene expression between the CA-CC from wild type (WT) and epox -/- adult female mosquitoes. From 18,034 identified genes, 317 were significantly differentially expressed. These genes are involved in many biological processes, including the regulation of cell proliferation and apoptosis, energy metabolism, and nutritional uptake. In addition, the same CA-CC samples were also used to examine the microRNA (miRNA) profiles of epox -/- and WT mosquitoes. A total of 197 miRNAs were detected, 24 of which were differentially regulated in epox -/- mutants. miRNA binding sites for these particular miRNAs were identified using an in silico approach; they target a total of 101 differentially expressed genes. Our results suggest that a lack of epoxidase, besides affecting JH synthesis, results in the diminishing of JH signalling that have significant effects on Ae. aegypti CA-CC transcriptome profiles, as well as its miRNA repertoire.
(© 2024. The Author(s).)
References: Insect Mol Biol. 2014 Oct;23(5):539-49. (PMID: 24698447)
Curr Biol. 2019 Dec 2;29(23):R1252-R1268. (PMID: 31794762)
Arch Insect Biochem Physiol. 2022 May;110(1):e21880. (PMID: 35191078)
Insect Mol Biol. 2017 Oct;26(5):574-583. (PMID: 28574638)
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W451-4. (PMID: 16845047)
Insect Biochem Mol Biol. 2011 Mar;41(3):203-9. (PMID: 21195177)
Hum Genomics. 2009 Apr;3(3):281-90. (PMID: 19403462)
Insect Biochem Mol Biol. 2021 Sep;136:103611. (PMID: 34182107)
Front Physiol. 2019 Oct 25;10:1352. (PMID: 31708801)
FEBS Lett. 2018 Feb;592(4):599-609. (PMID: 29364502)
Insect Sci. 2019 Jun;26(3):424-440. (PMID: 29064633)
Front Cell Neurosci. 2019 May 15;13:192. (PMID: 31156389)
J Immunol. 2010 Jun 1;184(11):6053-9. (PMID: 20410487)
Cell Cycle. 2008 Aug 15;7(16):2601-8. (PMID: 18719372)
Sci Adv. 2021 Oct 15;7(42):eabh1434. (PMID: 34652942)
Front Genet. 2020 Nov 19;11:592595. (PMID: 33329739)
Insect Mol Biol. 2017 Dec;26(6):721-733. (PMID: 28776797)
Genetics. 2021 Apr 15;217(4):. (PMID: 33681970)
Genes (Basel). 2021 Apr 13;12(4):. (PMID: 33924421)
Genetics. 2014 Sep;198(1):45-57. (PMID: 25236448)
Gene. 2022 Mar 1;813:146095. (PMID: 34902509)
Genetics. 2007 Sep;177(1):295-306. (PMID: 17603127)
Bioinformatics. 2014 May 1;30(9):1236-40. (PMID: 24451626)
J Insect Physiol. 2011 Sep;57(9):1274-81. (PMID: 21708165)
Insect Biochem Mol Biol. 2015 Jun;61:1-7. (PMID: 25881968)
Cancer Med. 2019 Dec;8(18):7762-7773. (PMID: 31663688)
Arch Insect Biochem Physiol. 2017 Jan;94(1):. (PMID: 28042896)
Nucleic Acids Res. 2008 Jun;36(10):3420-35. (PMID: 18445632)
Open Biol. 2020 Sep;10(9):200029. (PMID: 32873153)
Curr Biol. 2024 Jan 8;:. (PMID: 38215744)
Insect Biochem Mol Biol. 2022 Apr;143:103743. (PMID: 35202811)
Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):139-144. (PMID: 29255055)
Dev Biol. 2006 Apr 15;292(2):381-92. (PMID: 16487504)
Front Physiol. 2022 May 09;13:873580. (PMID: 35615668)
Insects. 2021 Mar 11;12(3):. (PMID: 33799822)
Genes Dev. 2007 Sep 15;21(18):2277-82. (PMID: 17761811)
Mech Dev. 1993 Jan;40(1-2):47-61. (PMID: 8443106)
Curr Opin Genet Dev. 2006 Oct;16(5):533-9. (PMID: 16919443)
Insect Biochem Mol Biol. 2006 Apr;36(4):366-74. (PMID: 16551550)
PLoS Genet. 2020 Aug 7;16(8):e1008942. (PMID: 32764744)
PLoS Genet. 2017 Aug 7;13(8):e1006943. (PMID: 28787446)
Science. 2001 Apr 6;292(5514):107-10. (PMID: 11292875)
PLoS One. 2014 Jan 29;9(1):e86183. (PMID: 24489697)
Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3849-E3858. (PMID: 28439025)
PLoS Genet. 2019 Jun 26;15(6):e1008235. (PMID: 31242182)
Int J Mol Sci. 2020 Aug 22;21(17):. (PMID: 32842667)
Biochem J. 2005 Feb 15;386(Pt 1):145-52. (PMID: 15469415)
Insect Biochem Mol Biol. 2009 Nov;39(11):770-81. (PMID: 19748585)
Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):. (PMID: 34697248)
PLoS Genet. 2020 Apr 29;16(4):e1008762. (PMID: 32348297)
Front Cell Dev Biol. 2019 May 24;7:85. (PMID: 31231648)
Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1440-5. (PMID: 25605933)
J Hered. 2019 Jan 7;110(1):80-91. (PMID: 30445496)
PLoS One. 2012;7(5):e37730. (PMID: 22662202)
EMBO Rep. 2010 Aug;11(8):605-11. (PMID: 20559325)
Int J Mol Sci. 2019 Jun 10;20(11):. (PMID: 31185645)
Genes Dev. 2012 Jul 1;26(13):1427-32. (PMID: 22751499)
Genes (Basel). 2023 Apr 29;14(5):. (PMID: 37239372)
Insect Mol Biol. 2016 Dec;25(6):788-799. (PMID: 27515977)
Cell. 2009 Dec 11;139(6):1096-108. (PMID: 20005803)
Insect Mol Biol. 2021 Aug;30(4):446-458. (PMID: 33949026)
Int J Genomics. 2014;2014:970607. (PMID: 25180174)
Parasit Vectors. 2013 Sep 11;6(1):259. (PMID: 24020355)
Science. 2007 Dec 21;318(5858):1931-4. (PMID: 18048652)
Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):544-9. (PMID: 12522263)
Insect Biochem Mol Biol. 2018 May;96:10-18. (PMID: 29605533)
Parasit Vectors. 2013 Aug 08;6(1):230. (PMID: 23924583)
Commun Biol. 2021 Mar 22;4(1):384. (PMID: 33753888)
Dev Biol. 2004 Oct 15;274(2):280-94. (PMID: 15385159)
Insect Biochem Mol Biol. 2013 Jun;43(6):495-500. (PMID: 23541607)
BMC Genomics. 2003 Aug 12;4(1):33. (PMID: 12914675)
Cell Death Differ. 2012 May;19(5):839-46. (PMID: 22095284)
Genome Biol. 2003;5(1):R1. (PMID: 14709173)
Cell. 2006 Sep 22;126(6):1203-17. (PMID: 16990141)
Annu Rev Entomol. 2017 Jan 31;62:111-125. (PMID: 27813669)
Cell. 2015 Nov 5;163(4):907-19. (PMID: 26544939)
Nucleic Acids Res. 2019 Jan 8;47(D1):D309-D314. (PMID: 30418610)
Insect Biochem Mol Biol. 2022 Mar;142:103727. (PMID: 35092820)
معلومات مُعتمدة: R21 AI167849 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Aedes aegypti; Corpora allata; Epoxidase; Juvenile hormone; Mosquito; RNA-Seq; Transcriptome; microRNA
المشرفين على المادة: 0 (Juvenile Hormones)
0 (MicroRNAs)
تواريخ الأحداث: Date Created: 20240125 Date Completed: 20240129 Latest Revision: 20240201
رمز التحديث: 20240201
مُعرف محوري في PubMed: PMC10811912
DOI: 10.1186/s12864-024-10007-9
PMID: 38273232
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2164
DOI:10.1186/s12864-024-10007-9