دورية أكاديمية
أعرض في EDS

Acute Response of the Noninfarcted Myocardium and Surrounding Tissue Assessed by T2 Mapping After STEMI.

التفاصيل البيبلوغرافية
العنوان: Acute Response of the Noninfarcted Myocardium and Surrounding Tissue Assessed by T2 Mapping After STEMI.
المؤلفون: Bergamaschi L; Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland., Landi A; Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland., Maurizi N; Center for Cardiac Magnetic Resonance of the CHUV (CRMC), Lausanne University Hospital, Lausanne, Switzerland; Department of Cardiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Pizzi C; Cardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences-DIMEC-Alma Mater Studiorum, University of Bologna, Bologna, Italy., Leo LA; Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland., Arangalage D; Department of Cardiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Iglesias JF; Department of Cardiology, Geneva University Hospitals, Geneva, Switzerland., Eeckhout E; Department of Cardiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland; University of Lausanne (Unil), Lausanne, Switzerland., Schwitter J; Center for Cardiac Magnetic Resonance of the CHUV (CRMC), Lausanne University Hospital, Lausanne, Switzerland; Department of Cardiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland; University of Lausanne (Unil), Lausanne, Switzerland., Valgimigli M; Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland., Pavon AG; Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland; Center for Cardiac Magnetic Resonance of the CHUV (CRMC), Lausanne University Hospital, Lausanne, Switzerland. Electronic address: annagiulia.pavon@eoc.ch.
المصدر: JACC. Cardiovascular imaging [JACC Cardiovasc Imaging] 2024 Jun; Vol. 17 (6), pp. 610-621. Date of Electronic Publication: 2024 Jan 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101467978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7591 (Electronic) Linking ISSN: 18767591 NLM ISO Abbreviation: JACC Cardiovasc Imaging Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York : Elsevier
مواضيع طبية MeSH: ST Elevation Myocardial Infarction*/diagnostic imaging , ST Elevation Myocardial Infarction*/mortality , ST Elevation Myocardial Infarction*/therapy , ST Elevation Myocardial Infarction*/physiopathology , Percutaneous Coronary Intervention*/adverse effects , Percutaneous Coronary Intervention*/mortality , Myocardium*/pathology , Predictive Value of Tests*, Humans ; Male ; Female ; Middle Aged ; Aged ; Time Factors ; Risk Factors ; Treatment Outcome ; Edema, Cardiac/diagnostic imaging ; Edema, Cardiac/physiopathology ; Edema, Cardiac/etiology ; Magnetic Resonance Imaging, Cine ; Magnetic Resonance Imaging ; Patient Readmission ; Pectoralis Muscles/diagnostic imaging ; Ventricular Function, Left ; Liver/diagnostic imaging ; Liver/pathology ; Spleen/diagnostic imaging
مستخلص: Background: ST-segment elevation myocardial infarction (STEMI) is associated with a systemic and local inflammatory response with edema. However, their role at the tissue level is poorly characterized.
Objectives: This study aims to characterize T2 values of the noninfarcted myocardium (NIM) and surrounding tissue and to investigate prognostic relevance of higher NIM T2 values after STEMI.
Methods: A total of 171 consecutive patients with STEMI without prior cardiovascular events who underwent cardiac magnetic resonance after primary percutaneous coronary intervention were analyzed in terms of standard infarct characteristics. Edema of the NIM, liver, spleen, and pectoralis muscle was assessed based on T2 mapping. Follow-up was available for 130 patients. The primary endpoint was major adverse cardiac events (MACE), defined as cardiovascular death, myocardial infarction, unplanned coronary revascularization or rehospitalization for heart failure. The median time from primary percutaneous coronary intervention to cardiac magnetic resonance was 3 days (IQR: 2-5 days).
Results: Higher (above the median value of 45 ms) T2 values in the NIM area were associated with larger infarct size, microvascular obstruction, and left ventricular dysfunction and did not correlate with C-reactive protein, white blood cells, or T2 values of the pectoralis muscle, liver, and spleen. At a median follow-up of 17 months, patients with higher (>45 ms) NIM T2 values had increased risk of MACE (P < 0.001) compared with subjects with NIM T2 values ≤45 ms, mainly caused by a higher rate of myocardial reinfarction (26.3% vs 1.4%; P < 0.001). At multivariable analysis, higher NIM T2 values independently predicted MACE (HR: 2.824 [95% CI: 1.254-6.361]; P = 0.012).
Conclusions: Higher NIM T2 values after STEMI are independently associated with worse cardiovascular outcomes, mainly because of higher risk of myocardial infarction.
Competing Interests: Funding Support and Author Disclosures The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
(Copyright © 2024 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: ST-elevation myocardial infarction; acute response; cardiovascular magnetic resonance; mapping; noninfarcted myocardium; prognosis; surrounding tissue
تواريخ الأحداث: Date Created: 20240126 Date Completed: 20240605 Latest Revision: 20240605
رمز التحديث: 20240606
DOI: 10.1016/j.jcmg.2023.11.014
PMID: 38276932
قاعدة البيانات: MEDLINE
الوصف
تدمد:1876-7591
DOI:10.1016/j.jcmg.2023.11.014