التفاصيل البيبلوغرافية
| العنوان: |
Systemic Immune Modulation by Gastrointestinal Nematodes. |
| المؤلفون: |
Kasal DN; Department of Immunology, University of Washington, Seattle, Washington, USA; email: jmoltke@uw.edu., Warner LM; Department of Immunology, University of Washington, Seattle, Washington, USA; email: jmoltke@uw.edu., Bryant AS; Department of Physiology and Biophysics, University of Washington, Seattle, Washington, USA., Tait Wojno E; Department of Immunology, University of Washington, Seattle, Washington, USA; email: jmoltke@uw.edu., von Moltke J; Department of Immunology, University of Washington, Seattle, Washington, USA; email: jmoltke@uw.edu. |
| المصدر: |
Annual review of immunology [Annu Rev Immunol] 2024 Jun; Vol. 42 (1), pp. 259-288. Date of Electronic Publication: 2024 Jun 14. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Annual Reviews Inc Country of Publication: United States NLM ID: 8309206 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-3278 (Electronic) Linking ISSN: 07320582 NLM ISO Abbreviation: Annu Rev Immunol Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Palo Alto, Calif. : Annual Reviews Inc., c1983- |
| مواضيع طبية MeSH: |
Nematode Infections*/immunology , Nematoda*/immunology , Nematoda*/physiology , Gastrointestinal Microbiome*/immunology, Animals ; Humans ; Immunomodulation ; Host-Parasite Interactions/immunology ; Intestinal Diseases, Parasitic/immunology ; Immune Tolerance ; Gastrointestinal Tract/immunology ; Gastrointestinal Tract/parasitology |
| مستخلص: |
Gastrointestinal nematode (GIN) infection has applied significant evolutionary pressure to the mammalian immune system and remains a global economic and human health burden. Upon infection, type 2 immune sentinels activate a common antihelminth response that mobilizes and remodels the intestinal tissue for effector function; however, there is growing appreciation of the impact GIN infection also has on the distal tissue immune state. Indeed, this effect is observed even in tissues through which GINs never transit. This review highlights how GIN infection modulates systemic immunity through ( a ) induction of host resistance and tolerance responses, ( b ) secretion of immunomodulatory products, and ( c ) interaction with the intestinal microbiome. It also discusses the direct consequences that changes to distal tissue immunity can have for concurrent and subsequent infection, chronic noncommunicable diseases, and vaccination efficacy. |
| فهرسة مساهمة: |
Keywords: helminth infection; host–parasite interaction; mucosal immunity; type 2 immunity |
| تواريخ الأحداث: |
Date Created: 20240126 Date Completed: 20240628 Latest Revision: 20240628 |
| رمز التحديث: |
20240629 |
| DOI: |
10.1146/annurev-immunol-090222-101331 |
| PMID: |
38277692 |
| قاعدة البيانات: |
MEDLINE |
