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A case of spindle and giant cell-type undifferentiated carcinoma of the extrahepatic bile duct.

التفاصيل البيبلوغرافية
العنوان: A case of spindle and giant cell-type undifferentiated carcinoma of the extrahepatic bile duct.
المؤلفون: Nagata K; Department of Surgery, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe, Hyogo, 651-2273, Japan., Nakamura K; Department of Surgery, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe, Hyogo, 651-2273, Japan. kojiro@kuhp.kyoto-u.ac.jp.; Department of Surgery, National Hospital Organization, Kyoto Medical Center, 1-1 Fukakusamukaihata-cho, Fushimi-ku, Kyoto, 612-8555, Japan. kojiro@kuhp.kyoto-u.ac.jp., Iida T; Department of Surgery, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe, Hyogo, 651-2273, Japan., Iwasaki J; Department of Surgery, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe, Hyogo, 651-2273, Japan., Hata T; Department of Surgery, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe, Hyogo, 651-2273, Japan., Yoshino K; Department of Surgery, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe, Hyogo, 651-2273, Japan., Asai S; Department of Diagnostic Pathology, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe, Hyogo, 651-2273, Japan., Ishihara M; Department of Diagnostic Pathology, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe, Hyogo, 651-2273, Japan., Itami A; Department of Surgery, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe, Hyogo, 651-2273, Japan., Kyogoku T; Department of Surgery, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe, Hyogo, 651-2273, Japan.
المصدر: Clinical journal of gastroenterology [Clin J Gastroenterol] 2024 Apr; Vol. 17 (2), pp. 345-351. Date of Electronic Publication: 2024 Jan 28.
نوع المنشور: Case Reports; Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Japan Country of Publication: Japan NLM ID: 101477246 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-7265 (Electronic) Linking ISSN: 18657265 NLM ISO Abbreviation: Clin J Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Tokyo] : Springer Japan
مواضيع طبية MeSH: Bile Duct Neoplasms*/diagnosis , Bile Duct Neoplasms*/surgery , Bile Duct Neoplasms*/pathology , Bile Ducts, Extrahepatic*/pathology , Bile Ducts, Extrahepatic*/surgery , Carcinoma*/surgery , Carcinoma*/pathology, Male ; Humans ; Aged ; Common Bile Duct/pathology ; Giant Cells/pathology
مستخلص: Spindle and giant cell type undifferentiated carcinoma of the extrahepatic bile duct is an uncommon malignancy. We report a case involving the common bile duct in a 72-year-old male with jaundice who was admitted to our hospital. Diagnostic imaging, including abdominal computed tomography and magnetic resonance imaging, revealed a mass in the distal common bile duct, accompanied by dilatation of both intra- and extrahepatic bile ducts and regional lymph node enlargement. Endoscopic retrograde cholangiography demonstrated stenosis in the distal common bile duct, with a biopsy confirming adenocarcinoma. The patient underwent endoscopic retrograde biliary drainage followed by a subtotal stomach-preserving pancreaticoduodenectomy with regional lymphadenectomy. Microscopic examination revealed that the tumor predominantly comprised spindle and giant atypical cells within the stroma. Immunohistochemical analysis showed the tumor cells expressing cytokeratins and mesenchymal markers, confirming the diagnosis of spindle and giant cell type undifferentiated carcinoma of the common bile duct. Ki-67 labeling index was observed to be above 80%. Postoperatively, intra-abdominal lymph node recurrence was noted at two months, and multiple liver metastases were identified at three months. The patient died seven months post-surgery. The literature pertaining to this rare disease is reviewed and discussed.
(© 2024. Japanese Society of Gastroenterology.)
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معلومات مُعتمدة: 19K24012 Ministry of Education, Culture, Science and Sports; 22K08749 Ministry of Education, Culture, Science and Sports
فهرسة مساهمة: Keywords: Bile duct cancer; Rapid recurrence; Spindle and giant cell type; Surgery; Undifferentiated carcinoma
تواريخ الأحداث: Date Created: 20240128 Date Completed: 20240325 Latest Revision: 20240325
رمز التحديث: 20240325
DOI: 10.1007/s12328-023-01913-8
PMID: 38281288
قاعدة البيانات: MEDLINE
الوصف
تدمد:1865-7265
DOI:10.1007/s12328-023-01913-8