دورية أكاديمية
Prenatal cannabis use and the risk of attention deficit hyperactivity disorder and autism spectrum disorder in offspring: A systematic review and meta-analysis.
| العنوان: | Prenatal cannabis use and the risk of attention deficit hyperactivity disorder and autism spectrum disorder in offspring: A systematic review and meta-analysis. |
|---|---|
| المؤلفون: | Tadesse AW; School of Population Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia; Department of Public Health, College of Medicine and Health Sciences, Samara University, 132, Semera, Ethiopia. Electronic address: tadesse.woday@postgrad.curtin.edu.au., Dachew BA; School of Population Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia., Ayano G; School of Population Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia., Betts K; School of Population Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia., Alati R; School of Population Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia; Institute for Social Sciences Research, The University of Queensland, 80 Meier's Rd, Indooroopilly, QLD, 4068, Australia. |
| المصدر: | Journal of psychiatric research [J Psychiatr Res] 2024 Mar; Vol. 171, pp. 142-151. Date of Electronic Publication: 2024 Jan 23. |
| نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res |
| أسماء مطبوعة: | Original Publication: Oxford : Pergamon Press |
| مواضيع طبية MeSH: | Attention Deficit Disorder with Hyperactivity*/epidemiology , Attention Deficit Disorder with Hyperactivity*/chemically induced , Attention Deficit Disorder with Hyperactivity*/etiology , Autism Spectrum Disorder*/epidemiology , Autism Spectrum Disorder*/chemically induced , Autism Spectrum Disorder*/etiology , Prenatal Exposure Delayed Effects*/chemically induced, Humans ; Pregnancy ; Female ; Marijuana Use/adverse effects ; Marijuana Use/epidemiology |
| مستخلص: | Background: It is plausible that exposure to cannabis in-utero could be associated with an increased risk of neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD) symptoms and autism spectrum disorder (ASD) during childhood and adolescence; however, mixed results have been reported. This study investigated whether there is an association between prenatal cannabis use and ADHD symptoms and ASD in offspring using a systematic review and meta-analysis methodology. Methods: A systematic literature search was conducted in PubMed/Medline, Scopus, EMBASE, Web of Science, Psych-Info, and Google Scholar to identify relevant studies. The study protocol has been preregistered in the Prospective Register of Systematic Reviews (PROSPERO) (CRD42022345001), and the Newcastle-Ottawa Quality Assessment Scale (NOS) was used to assess the methodological quality of included studies. An inverse variance weighted random effect meta-analysis was conducted to pool the overall effect estimates from the included studies. Results: Fourteen primary studies, consisting of ten on ADHD and four on ASD, with a total of 203,783 participants, were included in this study. Our meta-analysis underscores an increased risk of ADHD symptoms and/or disorder [β = 0.39: 95 % CI (0.20-0.58), I 2 = 66.85 %, P = 0.001)] and ASD [RR = 1.30: 95 % CI (1.03-1.64), I 2 = 45.5 %, P = 0.14] associated with in-utero cannabis exposure in offspring compared to their non-exposed counterparts. Additionally, our stratified analysis highlighted an elevated risk of ADHD symptoms [β = 0.54: 95 % CI (0.26-0.82)] and a marginally significant increase in the risk of diagnostic ADHD among exposed offspring compared to non-exposed counterparts [RR = 1.13, 95 % CI (1.01, 1.26)]. Conclusion: This study indicated that maternal prenatal cannabis exposure is associated with a higher risk of ADHD symptoms and ASD in offspring. Competing Interests: Declaration of competing interest All authors have no conflicts of interest to disclose. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ADHD; ASD; Cannabis; Marijuana; Neurodevelopmental disorders; Offspring; Pregnancy; Prenatal |
| تواريخ الأحداث: | Date Created: 20240128 Date Completed: 20240807 Latest Revision: 20240807 |
| رمز التحديث: | 20240808 |
| DOI: | 10.1016/j.jpsychires.2024.01.045 |
| PMID: | 38281464 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-1379 |
|---|---|
| DOI: | 10.1016/j.jpsychires.2024.01.045 |