دورية أكاديمية
Effect of human umbilical cord blood-mesenchymal stem cells on cisplatin-induced nephrotoxicity in rats.
| العنوان: | Effect of human umbilical cord blood-mesenchymal stem cells on cisplatin-induced nephrotoxicity in rats. |
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| المؤلفون: | Hussein S; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. samiahussein82@hotmail.com., Hasan MM; Physiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Saeed AA; Physiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Tolba AM; Anatomy and Embryology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Sameh R; Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Abdelghany EMA; Anatomy and Embryology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. |
| المصدر: | Molecular biology reports [Mol Biol Rep] 2024 Jan 28; Vol. 51 (1), pp. 234. Date of Electronic Publication: 2024 Jan 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Dordrecht, Boston, Reidel. |
| مواضيع طبية MeSH: | Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cell Transplantation*, Humans ; Rats ; Animals ; Cisplatin/adverse effects ; Cisplatin/metabolism ; Fetal Blood ; Stem Cells ; Oxidants/metabolism |
| مستخلص: | Background: Cisplatin-containing regimen is an effective treatment for several malignancies. However, cisplatin is an important cause of nephrotoxicity. So, many trials were performed to transplant stem cells systemically or locally to control cisplatin-induced nephrotoxicity. Stem cell therapeutic effect may be dependent on the regulation of inflammation and oxidant stress. Aim: To investigate the effect of human umbilical cord blood-mesenchymal stem cells (hUCB-MSCs) on the histological structure, the oxidant stress, and the inflammatory gene expression in an experimental model of cisplatin-induced nephrotoxicity in rats. Method: The rats were divided into 6 equal groups (each of 10 rats): Group I included normal rats that received no treatment. Group II included healthy rats that received IV hUCB-MSCs. Group III included untreated cisplatin-induced nephrotoxic rats. Group IV included cisplatin-induced nephrotoxic rats that received magnesium (Mg) injections after injury. Group V was injected with hUCB-MSCs after injury. Group VI received both Mg and hUCB-MSCs after injury. In tissue homogenates, reduced glutathione (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA) activities were measured. Quantitative real-time-polymerase chain reaction (qRT-PCR) was performed to assess iNOS, TLR4, and NF-kB gene expression. Hematoxylin and eosin (H&E) staining was performed to study the histological structure of the kidney. Immunohistochemical staining of iNOS and NF-κB was performed, as well. Results: Disturbed kidney functions, oxidative status, and histological structure were seen in the rats that received cisplatin. Treated groups showed improvements in kidney functions, oxidative status, and histological structure, particularly in the combined treatment group. Conclusion: In the cisplatin-induced nephrotoxicity model, hUCB-MSCs could improve the functional and morphological kidney structure by modulation of oxidative and inflammatory status. (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.) |
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| فهرسة مساهمة: | Keywords: Cisplatin; Human umbilical cord blood-mesenchymal stem cells; Mg; Nephrotoxicity; qRT- PCR |
| المشرفين على المادة: | Q20Q21Q62J (Cisplatin) 0 (Oxidants) |
| تواريخ الأحداث: | Date Created: 20240128 Date Completed: 20240130 Latest Revision: 20240130 |
| رمز التحديث: | 20240130 |
| DOI: | 10.1007/s11033-023-08958-5 |
| PMID: | 38282086 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-4978 |
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| DOI: | 10.1007/s11033-023-08958-5 |