دورية أكاديمية
أعرض في EDS

Wide dynamic range measurement of blood flow in vivo using laser speckle contrast imaging.

التفاصيل البيبلوغرافية
العنوان: Wide dynamic range measurement of blood flow in vivo using laser speckle contrast imaging.
المؤلفون: Liu HL; Beijing Anzhen Hospital of Capital Medical University, Department of Cardiovascular Surgery, Beijing, China., Yuan Y; Chinese Academy of Sciences, Technical Institute of Physics and Chemistry, Center of Applied Laser, Beijing, China., Han L; Chinese Academy of Sciences, Technical Institute of Physics and Chemistry, Center of Applied Laser, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Bi Y; Chinese Academy of Sciences, Technical Institute of Physics and Chemistry, Center of Applied Laser, Beijing, China., Yu WY; Beijing Anzhen Hospital of Capital Medical University, Department of Cardiovascular Surgery, Beijing, China., Yu Y; Beijing Anzhen Hospital of Capital Medical University, Department of Cardiovascular Surgery, Beijing, China.
المصدر: Journal of biomedical optics [J Biomed Opt] 2024 Jan; Vol. 29 (1), pp. 016009. Date of Electronic Publication: 2024 Jan 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society Country of Publication: United States NLM ID: 9605853 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1560-2281 (Electronic) Linking ISSN: 10833668 NLM ISO Abbreviation: J Biomed Opt Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Bellingham, WA : Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society, c1996-
مواضيع طبية MeSH: Laser Speckle Contrast Imaging* , Hemodynamics*, Rats ; Animals ; Rabbits ; Blood Flow Velocity ; Regional Blood Flow/physiology ; Veins ; Laser-Doppler Flowmetry/methods
مستخلص: Significance: Laser speckle contrast imaging (LSCI) is a real-time wide-field technique that is applied to visualize blood flow in biomedical applications. However, there is currently a lack of relevant research to demonstrate that it can measure velocities over a wide dynamic range (WDR), which is critical for monitoring much higher and more pulsatile blood flow in larger size myocardial vessels, such as the coronary artery bypass graft, and visualizing the spatio-temporal evolution of myocardial blood flow perfusion in cardiac surgery.
Aim: We aim to demonstrate that the LSCI technique enables measuring velocities over a WDR from phantom experiments to animal experiments. In addition, LSCI is preliminarily applied to imaging myocardial blood flow distribution in vivo on rabbits.
Approach: Phantom and animal experiments are performed to verify that the LSCI method has the ability to measure blood velocities over a wide range. Our method is also validated by transit time flow measurement, which is the gold standard for blood flow measurement in cardiac surgery.
Results: Our method is demonstrated to measure the blood flow over a wide range from 0.2 to 635    mm / s . To validate the phantom results, the varying blood flow rate from 0 to 320    mm / s is detected in the rat carotid artery. Additionally, our technique also obtains blood flow maps of different myocardial vessels, such as superficial large/small veins, veins surrounded by fat, and myocardial deeper arteriole.
Conclusions: Our study has the potential to visualize the spatio-temporal evolution of myocardial perfusion in coronary artery bypass grafting, which would be of great benefit for future research in the life sciences and clinical medicine.
(© 2024 The Authors.)
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فهرسة مساهمة: Keywords: blood flow; laser speckle contrast imaging; myocardial vessel imaging; wide dynamic range
تواريخ الأحداث: Date Created: 20240129 Date Completed: 20240130 Latest Revision: 20240422
رمز التحديث: 20240422
مُعرف محوري في PubMed: PMC10821768
DOI: 10.1117/1.JBO.29.1.016009
PMID: 38283936
قاعدة البيانات: MEDLINE
الوصف
تدمد:1560-2281
DOI:10.1117/1.JBO.29.1.016009