Balanced spatiotemporal arrangements of histone H3 and H4 posttranslational modifications are necessary for meiotic prophase I chromosome organization.

التفاصيل البيبلوغرافية
العنوان:	Balanced spatiotemporal arrangements of histone H3 and H4 posttranslational modifications are necessary for meiotic prophase I chromosome organization.
المؤلفون:	Kumar SL; National Institute of Animal Biotechnology, Hyderabad, Telangana, India.; Graduate Studies, Regional Center for Biotechnology, Faridabad, Haryana, India., Mohanty A; National Institute of Animal Biotechnology, Hyderabad, Telangana, India.; Graduate Studies, Regional Center for Biotechnology, Faridabad, Haryana, India., Kumari A; National Institute of Animal Biotechnology, Hyderabad, Telangana, India.; Graduate Studies, Regional Center for Biotechnology, Faridabad, Haryana, India., Etikuppam AK; National Institute of Animal Biotechnology, Hyderabad, Telangana, India.; Graduate Studies, Regional Center for Biotechnology, Faridabad, Haryana, India., Kumar S R; National Institute of Animal Biotechnology, Hyderabad, Telangana, India., Athar M; National Institute of Animal Biotechnology, Hyderabad, Telangana, India.; Graduate Studies, Regional Center for Biotechnology, Faridabad, Haryana, India., Kumar P K; National Institute of Animal Biotechnology, Hyderabad, Telangana, India., Beniwal R; National Institute of Animal Biotechnology, Hyderabad, Telangana, India.; Graduate Studies, Regional Center for Biotechnology, Faridabad, Haryana, India., Potula MM; National Institute of Animal Biotechnology, Hyderabad, Telangana, India., Gandham RK; Division of Veterinary Biotechnology, ICAR-IVRI, Izatnagar, Bareilly, Uttar Pradesh, India., Rao HBDP; National Institute of Animal Biotechnology, Hyderabad, Telangana, India.
المصدر:	Journal of cellular physiology [J Cell Physiol] 2024 Apr; Vol. 239 (4), pp. e31201. Date of Electronic Publication: 2024 Jan 29.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0050222 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4652 (Electronic) Linking ISSN: 00219541 NLM ISO Abbreviation: J Cell Physiol Subsets: MEDLINE
أسماء مطبوعة:	Publication: New York, NY : Wiley-Liss Original Publication: Philadelphia, Wistar Institute of Anatomy and Biology.
مواضيع طبية MeSH:	Histones/metabolism , Meiotic Prophase I , Protein Processing, Post-Translational* , Spermatocytes/cytology , Spermatocytes/metabolism, Animals ; Male ; Mice ; Chromatin/genetics ; Heterochromatin ; Meiosis
مستخلص:	Dynamic nuclear architecture and chromatin organizations are the key features of the mid-prophase I in mammalian meiosis. The chromatin undergoes major changes, including meiosis-specific spatiotemporal arrangements and remodeling, the establishment of chromatin loop-axis structure, pairing, and crossing over between homologous chromosomes, any deficiencies in these events may induce genome instability, subsequently leading to failure to produce gametes and infertility. Despite the significance of chromatin structure, little is known about the location of chromatin marks and the necessity of their balance during meiosis prophase I. Here, we show a thorough cytological study of the surface-spread meiotic chromosomes of mouse spermatocytes for H3K9,14,18,23,27,36, H4K12,16 acetylation, and H3K4,9,27,36 methylation. Active acetylation and methylation marks on H3 and H4, such as H3K9ac, H3K14ac, H3K18ac, H3K36ac, H3K56ac, H4K12ac, H4K16ac, and H3K36me3 exhibited pan-nuclear localization away from heterochromatin. In comparison, repressive marks like H3K9me3 and H3K27me3 are localized to heterochromatin. Further, taking advantage of the delivery of small-molecule chemical inhibitors methotrexate (heterochromatin enhancer), heterochromatin inhibitor, anacardic acid (histone acetyltransferase inhibitor), trichostatin A (histone deacetylase inhibitor), IOX1 (JmjC demethylases inhibitor), and AZ505 (methyltransferase inhibitor) in seminiferous tubules through the rete testis route, revealed that alteration in histone modifications enhanced the centromere mislocalization, chromosome breakage, altered meiotic recombination and reduced sperm count. Specifically, IOX1 and AZ505 treatment shows severe meiotic phenotypes, including altering chromosome axis length and chromatin loop size via transcriptional regulation of meiosis-specific genes. Our findings highlight the importance of balanced chromatin modifications in meiotic prophase I chromosome organization and instability. (© 2024 Wiley Periodicals LLC.)
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معلومات مُعتمدة:	C0031 NIAB core funds; BT/PR31689/AAQ/1/747/2019 DBT; BT/RLF/Re-entry/21/2016 DBT Ramalingaswami fellowship
فهرسة مساهمة:	Keywords: chromatin organization; genome stability; histone H3 and H4 posttranslational modifications; meiosis prophase I
تواريخ الأحداث:	Date Created: 20240129 Date Completed: 20240412 Latest Revision: 20240520
رمز التحديث:	20240521
DOI:	10.1002/jcp.31201
PMID:	38284481
قاعدة البيانات:	MEDLINE

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تدمد:	1097-4652
DOI:	10.1002/jcp.31201