دورية أكاديمية
أعرض في EDS

The effect of emotional faces on reward-related probability learning in depressed patients.

التفاصيل البيبلوغرافية
العنوان: The effect of emotional faces on reward-related probability learning in depressed patients.
المؤلفون: Keskin-Gokcelli D; SoCAT Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital, RWTH Aachen, Aachen, Germany., Kizilates-Evin G; SoCAT Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey; Hulusi Behcet Life Sciences Research Laboratory, Neuroimaging Unit, Istanbul University, Istanbul, Turkey., Eroglu-Koc S; SoCAT Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey; Department of Psychology, Faculty of Letters, Dokuz Eylul University, Izmir, Turkey., Oguz K; SoCAT Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey; Department of Computer Engineering, Izmir University of Economics, Izmir, Turkey., Eraslan C; SoCAT Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey; Department of Radiology, School of Medicine, Ege University, Izmir, Turkey., Kitis O; SoCAT Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey; Department of Radiology, School of Medicine, Ege University, Izmir, Turkey., Gonul AS; SoCAT Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey; Department of Psychiatry and Behavioral Sciences, Mercer School of Medicine, Mercer University, Macon, GA, USA. Electronic address: ali.saffet.gonul@ege.edu.tr.
المصدر: Journal of affective disorders [J Affect Disord] 2024 Apr 15; Vol. 351, pp. 184-193. Date of Electronic Publication: 2024 Jan 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Depressive Disorder, Major*/drug therapy, Humans ; Probability Learning ; Facial Expression ; Emotions/physiology ; Happiness ; Magnetic Resonance Imaging ; Brain Mapping
مستخلص: Background: Existing research indicates that individuals with Major Depressive Disorder (MDD) exhibit a bias toward salient negative stimuli. However, the impact of such biased stimuli on concurrent cognitive and affective processes in individuals with depression remains inadequately understood. This study aimed to investigate the effects of salient environmental stimuli, specifically emotional faces, on reward-associated processes in MDD.
Methods: Thirty-three patients with recurrent MDD and thirty-two healthy controls (HC) matched for age, sex, and education were included in the study. We used a reward-related associative learning (RRAL) task primed with emotional (happy, sad, neutral) faces to investigate the effect of salient stimuli on reward-related learning and decision-making in functional magnetic resonance imaging (fMRI). Participants were instructed to ignore emotional faces during the task. The fMRI data were analyzed using a full-factorial general linear model (GLM) in Statistical Parametric Mapping (SPM12).
Results: In depressed patients, cues primed with sad faces were associated with reduced amygdala activation. However, both HC and MDD group exhibited reduced ventral striatal activity while learning reward-related cues and receiving rewards.
Limitations: The patients'medication usage was not standardized.
Conclusions: This study underscores the functional alteration of the amygdala in response to cognitive tasks presented with negative emotionally salient stimuli in the environment of MDD patients. The observed alterations in amygdala activity suggest potential interconnected effects with other regions of the prefrontal cortex. Understanding the intricate neural connections and their disruptions in depression is crucial for unraveling the complex pathophysiology of the disorder.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Amygdala; Depression; Probabilistic reward learning; Reward processing; Striatum; fMRI
تواريخ الأحداث: Date Created: 20240129 Date Completed: 20240228 Latest Revision: 20240228
رمز التحديث: 20240228
DOI: 10.1016/j.jad.2024.01.247
PMID: 38286231
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-2517
DOI:10.1016/j.jad.2024.01.247