دورية أكاديمية
The diagnostic value of bronchial provocation testing combined with fractional exhaled nitric oxide (FeNO) in children with chest tightness-variant asthma (CTVA).
| العنوان: | The diagnostic value of bronchial provocation testing combined with fractional exhaled nitric oxide (FeNO) in children with chest tightness-variant asthma (CTVA). |
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| المؤلفون: | Zhang T; Department of Respiration, Children's Hospital of Hebei Province, Shijiazhuang, China., Xu L; Department of Endocrinology, Genetics and Metabolism, Children's Hospital of Hebei Province, Shijiazhuang, China., Zhang Y; Department of Respiration, Children's Hospital of Hebei Province, Shijiazhuang, China., Zhen L; Department of Respiration, Children's Hospital of Hebei Province, Shijiazhuang, China. Electronic address: 464096045@qq.com. |
| المصدر: | Respiratory medicine [Respir Med] 2024 Mar; Vol. 223, pp. 107543. Date of Electronic Publication: 2024 Jan 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8908438 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3064 (Electronic) Linking ISSN: 09546111 NLM ISO Abbreviation: Respir Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : Oxford : Elsevier Original Publication: London : Baillière Tindall, in association with the British Thoracic Society, [c1989- |
| مواضيع طبية MeSH: | Fractional Exhaled Nitric Oxide Testing* , Asthma*/diagnosis, Child ; Humans ; Nitric Oxide ; Bronchial Provocation Tests ; Breath Tests |
| مستخلص: | Background: Chest tightness-variant asthma (CTVA) is a novel atypical asthma characterized by chest tightness as the sole or primary symptom. Objectives: To investigate the value of bronchial provocation testing combined with fractional exhaled nitric oxide (FeNO) in the diagnosis of CTVA in children. Methods: This study included 95 children aged 6-14 years with chest tightness as the sole symptom, with a duration of symptoms exceeding 4 weeks. All subjects underwent FeNO measurement, pulmonary function testing, and bronchial provocation testing using the Astograph method. Subjects with positive bronchial provocation testing were classified as the CTVA group, while those with negative results served as the non-CTVA control group. Results: The lung function of children in both groups was normal. The FeNO level in the CTVA group was (22.35 ± 9.91) ppb, significantly higher than the control group (14.85 ± 5.63) ppb, with a statistically significant difference (P < 0.05). The value of FeNO in diagnosing CTVA was analyzed using an ROC curve, with an area under the curve of 0.073 (P < 0.05). The optimal cutoff point for diagnosing CTVA using FeNO was determined to be 18.5 ppb, with a sensitivity of 60.3 % and specificity of 77.8 %. There was a negative correlation between FeNO and Dmin as well as PD15 (P = 0.006). Conclusion: FeNO can serve as an adjunctive diagnostic tool for CTVA, with the optimal cutoff point for diagnosing CTVA being 18.5 ppb. However, FeNO is not a specific diagnostic marker for CTVA and should be used in conjunction with bronchial provocation testing to enhance its diagnostic value. Competing Interests: Declaration of competing interest None. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bronchial provocation testing; CTVA; Chest tightness-variant asthma; Fractional exhaled nitric oxide |
| المشرفين على المادة: | 31C4KY9ESH (Nitric Oxide) |
| تواريخ الأحداث: | Date Created: 20240129 Date Completed: 20240226 Latest Revision: 20240226 |
| رمز التحديث: | 20240226 |
| DOI: | 10.1016/j.rmed.2024.107543 |
| PMID: | 38286340 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-3064 |
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| DOI: | 10.1016/j.rmed.2024.107543 |