دورية أكاديمية
أعرض في EDS

Analysis of the correlation between serum Klotho and FeNO: a cross-sectional study from NHANES (2007-2012).

التفاصيل البيبلوغرافية
العنوان: Analysis of the correlation between serum Klotho and FeNO: a cross-sectional study from NHANES (2007-2012).
المؤلفون: Mao H; Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, 315100, Ningbo, China., Xie Z; Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, 315100, Ningbo, China., Huang S; Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, 315100, Ningbo, China., Shen X; Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, 315100, Ningbo, China., Jin S; Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, 315100, Ningbo, China., Lin T; Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, 315100, Ningbo, China. kai893@foxmail.com., Yang Z; Zhejiang Provincial Key Lab of Geriatrics and Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, 310030, Hangzhou, China. yangzhouxin@hotmail.com.
المصدر: BMC pulmonary medicine [BMC Pulm Med] 2024 Jan 29; Vol. 24 (1), pp. 61. Date of Electronic Publication: 2024 Jan 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968563 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2466 (Electronic) Linking ISSN: 14712466 NLM ISO Abbreviation: BMC Pulm Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001]-
مواضيع طبية MeSH: Fractional Exhaled Nitric Oxide Testing* , Pulmonary Disease, Chronic Obstructive*/diagnosis, Humans ; Nutrition Surveys ; Cross-Sectional Studies ; Nitric Oxide/analysis ; Breath Tests ; Exhalation
مستخلص: Background: Klotho is an anti-aging protein that has multiple functions and may play a key role in the pathogenesis and progression of chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD). Fractional Exhaled Nitric Oxide (FeNO) is a non-invasive and novel biomarker that has the advantages of being simple, fast and reproducible. It can effectively assess the degree of airway inflammation in diseases such as asthma and COPD. Despite these insights, the relationship between serum Klotho levels and FeNO has not been explored yet.
Methods: Leveraging data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2012, we investigated the correlation between FeNO and serum Klotho levels. This association was scrutinized both as continuous variables and within quartile distributions, utilizing the Kruskal-Wallis H test. The correlation between the two variables was assessed through Spearman rank analysis. Employing survey weight-adjusted linear regression models, we gauged the strength of these associations.
Results: This study included 6,527 participants with a median FeNO level of 14.5 parts per billion (ppb). We found that FeNO levels varied significantly across different quartiles of Klotho protein (H = 7.985, P = 0.046). We also found a significant positive correlation between serum Klotho levels and FeNO levels in the whole population (Spearman's rho = 0.029, P = 0.019). This correlation remained significant after adjusting for covariates such as age, gender, lung function, smoking status, alcohol use, BMI, cardiovascular disease (including hypertension, heart failure, coronary heart disease, and myocardial infarction), diabetes, inflammatory markers, serum vitamin D level and BUN (P < 0.05 for all). Furthermore, this correlation was stronger at the high (K3) and super high (K4) levels of Klotho than at the low (K1) and medium (K2) levels (β = 1.979 ppb and β = 1.993 ppb for K3 and K4 vs. K1, respectively; 95% CI: 0.497 ~ 2.953 and 95% CI: 0.129 ~ 2.827, respectively; P = 0.007 and P = 0.032, respectively). The β coefficient for serum Klotho was 0.002 ppb/pg/ml.
Conclusions: Our study illuminates a positive correlation between serum Klotho levels and FeNO. Further study is needed to verify the causality of this association and elucidate the underlying mechanisms.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 2023KY244 Medical and Health Science and Technology Project of Zhejiang Province
فهرسة مساهمة: Keywords: Airway inflammation; Chronic respiratory diseases; FeNO; Klotho
المشرفين على المادة: 31C4KY9ESH (Nitric Oxide)
تواريخ الأحداث: Date Created: 20240129 Date Completed: 20240131 Latest Revision: 20240201
رمز التحديث: 20240201
مُعرف محوري في PubMed: PMC10823643
DOI: 10.1186/s12890-024-02864-7
PMID: 38287280
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2466
DOI:10.1186/s12890-024-02864-7