دورية أكاديمية
Exploring the short-term influence of a proprietary oil extract of black cumin ( Nigella sativa ) on non-restorative sleep: a randomized, double-blinded, placebo-controlled actigraphy study.
| العنوان: | Exploring the short-term influence of a proprietary oil extract of black cumin ( Nigella sativa ) on non-restorative sleep: a randomized, double-blinded, placebo-controlled actigraphy study. |
|---|---|
| المؤلفون: | Mohan ME; Department of General Medicine, BGS Global Institute of Medical Sciences, Kengeri, India., Mohan MC; Centre for Neuroscience, Cochin University of Science and Technology, Cochin, Kerala, India.; Department of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, India., Prabhakaran P; R&D Centre, Akay Natural Ingredients, Cochin, Kerala, India., Syam Das S; R&D Centre, Akay Natural Ingredients, Cochin, Kerala, India., Krishnakumar IM; R&D Centre, Akay Natural Ingredients, Cochin, Kerala, India., Baby Chakrapani PS; Centre for Neuroscience, Cochin University of Science and Technology, Cochin, Kerala, India.; Department of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, India.; Centre of Excellence in Neurodegeneration and Brain Health, Cochin, Kerala, India. |
| المصدر: | Frontiers in nutrition [Front Nutr] 2024 Jan 15; Vol. 10, pp. 1200118. Date of Electronic Publication: 2024 Jan 15 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 101642264 Publication Model: eCollection Cited Medium: Print ISSN: 2296-861X (Print) Linking ISSN: 2296861X NLM ISO Abbreviation: Front Nutr Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne, Switzerland : Frontiers Media S. A., [2014]- |
| مستخلص: | Background: Nigella sativa (black cumin, or black seed) is popularly known as the seed of blessings in the Arab system of medicine. Though not widely recommended for sleep, a unique proprietary black cumin extract (BlaQmax®/ThymoDream™; BCO-5) has been shown to be helpful in the management of stress and sleep issues. Methods: This randomized, double-blind, placebo-controlled trial aimed to investigate the efficacy of BCO-5 on the sleep quality of volunteers characterized with a self-reported non-restorative sleep disorder. Healthy male and female participants ( n = 70), aged 18-65 years (BMI 22-28 Kg/m 2 ) were randomized to either placebo or BCO-5 ( n = 35/group). Both interventions were supplemented at 200 mg/day for seven days. Actigraphy and a validated restorative sleep questionnaire (RSQ-W) were used to monitor the influence of BCO-5 on sleep. Results: Compared to placebo, BCO-5 significantly improved sleep quality, as evidenced by both intra-group and inter-group analyses of the actigraphy data. The relative improvements observed were sleep efficiency (7.8%, p < 0.001), total sleep time (19.1%, p < 0.001), sleep onset latency (35.4%; p < 0.001), and wake-after-sleep-onset (22.5%; p < 0.001) compared with placebo. BCO-5 also improved sleep by 75.3% compared to baseline ( p < 0.001) and by 68.9% compared to placebo ( p < 0.001), when monitored by RSQ-W. BCO-5 was well-tolerated with no reports of side effects or toxicity. Conclusion: BCO-5 significantly improved non-restorative sleep in seven days, indicating its potential role as a natural sleep aid. Competing Interests: BCO-5 used in the present study is a patented black cumin extract developed by Akay Natural Ingredients, Cochin, India and registered as BlaQmax®/ThymoDream™. MM, MCM, and PB belongs to non-profit research organizations who conducted the study and critically evaluated the data. PP, SS, and IK belong to the company Akay Natural Ingredients (Cochin, India), who prepared the study drugs, conceived the idea, and approved the protocol. (Copyright © 2024 Mohan, Mohan, Prabhakaran, Syam Das, Krishnakumar and Baby Chakrapani.) |
| التعليقات: | Erratum in: Front Nutr. 2024 Feb 13;11:1378259. (PMID: 38414487) |
| References: | Nutrients. 2021 May 24;13(6):. (PMID: 34073784) Front Endocrinol (Lausanne). 2022 Dec 19;13:1064969. (PMID: 36601010) Nutrients. 2021 Apr 27;13(5):. (PMID: 33925432) J Clin Sleep Med. 2014 Jul 15;10(7):733-41, 741A-741E. (PMID: 25024650) Nutrients. 2016 Jan 20;8(1):. (PMID: 26805875) J Nurs Scholarsh. 2019 Sep;51(5):500-508. (PMID: 31512821) P T. 2015 Nov;40(11):759-71. (PMID: 26609210) Saudi Pharm J. 2022 Dec;30(12):1781-1790. (PMID: 36601514) Sci Rep. 2019 Aug 26;9(1):12339. (PMID: 31451704) Front Sleep. 2022;1:. (PMID: 36042946) J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20967323. (PMID: 33086877) Int J Mol Sci. 2020 Dec 26;22(1):. (PMID: 33375373) Sleep. 2020 Mar 12;43(3):. (PMID: 31608395) J Ayurveda Integr Med. 2013 Apr;4(2):77-81. (PMID: 23930038) Curr Med Res Opin. 2004 Dec;20(12):1979-91. (PMID: 15701215) Respir Investig. 2019 May;57(3):227-237. (PMID: 30827934) Ger Med Sci. 2013 Jul 18;11:Doc10. (PMID: 23904824) BMJ Open Sport Exerc Med. 2018 Oct 04;4(1):e000392. (PMID: 30364557) Int Clin Psychopharmacol. 2020 Jan;35(1):29-35. (PMID: 31714321) Front Nutr. 2023 Apr 17;10:1152680. (PMID: 37139438) Biomed Pharmacother. 2021 Nov;143:112182. (PMID: 34649338) Complement Ther Med. 2017 Aug;33:58-64. (PMID: 28735826) Neurosci Lett. 2010 Jan 22;469(2):229-33. (PMID: 19969042) Eur Neuropsychopharmacol. 2015 Nov;25(11):1960-7. (PMID: 26293583) Sleep Med. 2022 Mar;91:253-261. (PMID: 34391672) Sleep Med Clin. 2017 Mar;12(1):1-22. (PMID: 28159089) Sleep. 2010 Apr;33(4):449-58. (PMID: 20394313) Int J Environ Res Public Health. 2020 Oct 04;17(19):. (PMID: 33020371) Br J Psychiatry. 2014 Nov;205(5):407-8. (PMID: 25061118) Lancet Neurol. 2021 Jan;20(1):15-17. (PMID: 33340475) Interface Focus. 2020 Jun 6;10(3):20190092. (PMID: 32382403) Sleep Med. 2005 Nov;6(6):487-95. (PMID: 16230048) J Sleep Res. 2019 Feb;28(1):e12712. (PMID: 29790200) Horm Metab Res. 2011 May;43(5):337-42. (PMID: 21332028) J Clin Sleep Med. 2017 Feb 15;13(2):275-281. (PMID: 27855744) Complement Ther Med. 2017 Dec;35:109-114. (PMID: 29154054) North Clin Istanb. 2018 May 29;5(4):295-301. (PMID: 30859159) Biol Psychiatry. 2006 Dec 15;60(12):1364-71. (PMID: 16952333) Toxicol Rep. 2022 Apr 20;9:999-1007. (PMID: 36518481) Cureus. 2019 Sep 28;11(9):e5797. (PMID: 31728244) Comb Chem High Throughput Screen. 2021;24(10):1644-1653. (PMID: 33115388) Sleep Sci. 2019 Oct-Dec;12(4):257-264. (PMID: 32318246) Int Clin Psychopharmacol. 1998 Jul;13(4):157-67. (PMID: 9727726) Eur J Neurol. 2012 Jan;19(1):155-62. (PMID: 22175760) Sleep Med. 2020 Aug;72:28-36. (PMID: 32540634) J Clin Med. 2021 Nov 08;10(21):. (PMID: 34768724) Front Nutr. 2023 Mar 28;10:1107750. (PMID: 37057067) J Sleep Res. 2017 Dec;26(6):675-700. (PMID: 28875581) Behav Res Methods. 2014 Dec;46(4):1032-41. (PMID: 24442593) Sci Pharm. 2013 Nov 05;82(1):161-70. (PMID: 24634848) Eur J Nutr. 2012 Dec;51(8):909-16. (PMID: 22038497) |
| فهرسة مساهمة: | Keywords: Nigella sativa; actigraphy; black cumin; insomnia; non-refreshing sleep; non-restorative sleep; thymoquinone |
| تواريخ الأحداث: | Date Created: 20240130 Latest Revision: 20240228 |
| رمز التحديث: | 20240228 |
| مُعرف محوري في PubMed: | PMC10822901 |
| DOI: | 10.3389/fnut.2023.1200118 |
| PMID: | 38288065 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-861X |
|---|---|
| DOI: | 10.3389/fnut.2023.1200118 |