دورية أكاديمية
Role of collagen and immunostaining for TGF-β in the clinical and microscopic findings of pyogenic granuloma and peripheral ossifying fibroma.
| العنوان: | Role of collagen and immunostaining for TGF-β in the clinical and microscopic findings of pyogenic granuloma and peripheral ossifying fibroma. |
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| المؤلفون: | Silva PG; Division of Oral Pathology, Dental School Federal University of Ceará Alexandre Barauna Street, 949, Rodolfo Teofilo 60430-160, Fortaleza, Ceará, Brazil paulo_goberlanio@yahoo.com.br., Paula DS, Soares GC, Cavalcante LN, Nascimento IV, Sousa FB, Mota MR, Alves AP |
| المصدر: | Medicina oral, patologia oral y cirugia bucal [Med Oral Patol Oral Cir Bucal] 2024 Mar 01; Vol. 29 (2), pp. e288-e296. Date of Electronic Publication: 2024 Mar 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medicina Oral S.L Country of Publication: Spain NLM ID: 101231694 Publication Model: Electronic Cited Medium: Internet ISSN: 1698-6946 (Electronic) Linking ISSN: 16984447 NLM ISO Abbreviation: Med Oral Patol Oral Cir Bucal Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Valencia, España : Medicina Oral S.L., [2004]- |
| مواضيع طبية MeSH: | Fibroma, Ossifying* , Granuloma, Pyogenic*/diagnosis , Gingival Neoplasms*, Humans ; Collagen Type I ; Collagen ; Transforming Growth Factor beta |
| مستخلص: | Background: Collagen is a component of Pyogenic Granuloma (PG) and Peripheral Ossifying Fibroma (POF) and performs different functions in these lesions. The objective of this study is to evaluate the role of collagen and immunostaining for Transforming Growth Factor beta (TGF-β) in the clinical and microscopic findings of PG and POF. Material and Methods: PG (n=20) and POF (n=20) were selected for clinical evaluation (sex, age, localization, size and evolution time) and microscopic analysis (picrosirius red staining for collagen analysis and immunohistochemistry for TGF-β) performed in the superficial and deep areas of the two lesions. ANOVA/Bonferroni and t-test, Pearson correlation and χ2 were used to compare the sites and parameters analyzed (p<0.05, GraphPad Prism 5.0). Results: The depth of PG presented the highest amount of collagen (p<0.001), and its surface showed the lowest amount of type 1 collagen (yellow-red strong birefringence). Type 1 collagen gradually increased in depth of PG, surface and depth of POF (p<0.001). The number of TGF-β+ cells was lower on the surface of PG compared with the depth of PG and the two areas of POF (p<0.001). Sex and localization did not affect these parameters, but the profile of collagen and immunostaining for TGF-β suffered from modifications by the time of evolution and the size of the lesion. Conclusions: Although PG and POF are reactive gingival lesions, the expression of TGF-β and its role in collagen showed different biological behaviors in these lesions, suggesting different biological origins for its components. |
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| المشرفين على المادة: | 0 (Collagen Type I) 9007-34-5 (Collagen) 0 (Transforming Growth Factor beta) |
| تواريخ الأحداث: | Date Created: 20240130 Date Completed: 20240304 Latest Revision: 20240320 |
| رمز التحديث: | 20240320 |
| مُعرف محوري في PubMed: | PMC10945864 |
| DOI: | 10.4317/medoral.26268 |
| PMID: | 38288849 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1698-6946 |
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| DOI: | 10.4317/medoral.26268 |