دورية أكاديمية
Chemical exploration of different extracts from Phytolacca americana leaves and their potential utilization for global health problems: ın silico and network pharmacology validation.
| العنوان: | Chemical exploration of different extracts from Phytolacca americana leaves and their potential utilization for global health problems: ın silico and network pharmacology validation. |
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| المؤلفون: | Fahmy NM; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt., Fayez S; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt., Zengin G; Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya, Turkey., Selvi S; Department of Plant and Animal Production, Altınoluk Vocational School, Balıkesir University, Balıkesir, Turkey., Uba AI; Department of Molecular Biology and Genetics, Istanbul AREL University, Istanbul, Turkey., Mollica A; Department of Pharmacy, 'G. D'Annunzio', University of Chieti-Pescara, Chieti, Italy., Bouyahya A; Laboratory of Human Pathologies Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco., Ponniya SKM; Department of Bioinformatics, Pondicherry University, Pudhucherry, India., Nilofar; Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya, Turkey.; Department of Pharmacy, Botanic Garden 'Giardino deiSemplici', Universitàdegli Studi 'Gabriele d'Annunzio', Chieti, Italy., Lekmine S; Biotechnology, Water, Environment and Health Laboratory, Abbes Laghrour University, Khenchela, Algeria., Ferrante C; Department of Pharmacy, Botanic Garden 'Giardino deiSemplici', Universitàdegli Studi 'Gabriele d'Annunzio', Chieti, Italy., Eldahshan OA; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.; Center of Drug Development Research and Discovery, Ain Shams University, Cairo, Egypt. |
| المصدر: | Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2024 Jan 30, pp. 1-21. Date of Electronic Publication: 2024 Jan 30. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: June 2012- : Oxon, UK : Taylor & Francis Original Publication: Guilderland, NY : Adenine Press, [c1983- |
| مستخلص: | Phytolacca americana L. is of great interest as a traditional additive in various folk remedies in several countries, including Turkey. We aimed to determine the chemical profile (assisted by high-Performance liquid chromatography-electrospray ionization-tandem mass apectrometry (HPLC-ESI-MS/MS) experiments of three extracts obtained by different polarity solvents viz. ethyl acetate (to extract semipolar compounds), methanol and water (to extract highly polar metabolites) from P. americana leaves. Their anti-diabetic effects were investigated in vitro by assessing their inhibition toα-amylase and α-glucosidase. Assessment of the neuroprotective potential of the three extracts was carried out against acetyl-(AChE) and butyryl-(BChE) cholinesterase enzymes. HPLC-ESI-MS/MS experiments showed a total of 17 chromatographic peaks primarily classified to six flavonoids, two saponins, and six fatty acids. Antioxidant assays revealed remarkable activity for the ethyl acetate and methanol extracts. The BChE inhibition was considerably more significant (4.08 mg galantamine equivalent (GALAE)/g) for the ethyl acetate extract, whereas the methanol extract had good inhibitory efficacy for AChE (2.05 mg GALAE/g). Through network pharmacology, the compounds' mechanism of action of targeted key gene in their associated diseases were identified. The hubb gene signal transducer and activator of transcription 3 (STAT3) and tumour necrosis factor (TNFα) where the P. americana compound's site of action in inflammation bowel disease. The results offer possibilities for the prospective application of P. americana in metabolic regulation, blood glucose control, and as a source of bioactive compounds with cholinesterase enzyme inhibitory characteristics which could be of relevance in the cosmetic or pharmaceutical industry for combating melanogenesis.Communicated by Ramaswamy H. Sarma. |
| فهرسة مساهمة: | Keywords: Phytolacca; bioactive compounds; network pharmacology; phytolaccagenin; saponins |
| تواريخ الأحداث: | Date Created: 20240130 Latest Revision: 20240130 |
| رمز التحديث: | 20240130 |
| DOI: | 10.1080/07391102.2024.2308770 |
| PMID: | 38288952 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1538-0254 |
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| DOI: | 10.1080/07391102.2024.2308770 |