دورية أكاديمية
Association of Altered Ratio of Maternal Folic Acid and Vitamin B12 during Pregnancy with Newborn Birth Weight, Head Circumference, and Chest Circumference.
| العنوان: | Association of Altered Ratio of Maternal Folic Acid and Vitamin B12 during Pregnancy with Newborn Birth Weight, Head Circumference, and Chest Circumference. |
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| المؤلفون: | Ramijinni RR; Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Mahajan A; Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Sapehia D; Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Singh P; Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Suri V; Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Kaur J; Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India. |
| المصدر: | Journal of the American Nutrition Association [J Am Nutr Assoc] 2024 Jul; Vol. 43 (5), pp. 452-463. Date of Electronic Publication: 2024 Jan 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 9918300687506676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2769-707X (Electronic) Linking ISSN: 27697061 NLM ISO Abbreviation: J Am Nutr Assoc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Philadelphia, Pennsylvania?] : Taylor & Francis Group, [2022]- |
| مواضيع طبية MeSH: | Vitamin B 12*/blood , Folic Acid*/blood , Birth Weight* , Fetal Blood*/metabolism , Fetal Blood*/chemistry, Humans ; Female ; Pregnancy ; Infant, Newborn ; Adult ; Vitamin B 12 Deficiency/blood ; Vitamin B 12 Deficiency/metabolism ; Homocysteine/blood ; Erythrocytes/metabolism ; Folic Acid Deficiency/blood ; Young Adult ; Head/anatomy & histology ; Placenta/metabolism ; Maternal Nutritional Physiological Phenomena |
| مستخلص: | Objective: This study evaluated the effect of an altered ratio of maternal RBC folate (MRF) to serum vitamin B12 (MB12) on pregnancy and newborn outcomes. Methods: Blood samples were collected from pregnant women and the umbilical cord at the time of delivery. Estimations of RBC folate and serum vitamin B12 from maternal and cord blood samples and total homocysteine (HCY) were performed. Maternal and newborn anthropometric parameters like placental weight (PW), head circumference (HC), chest circumference (CC), and body weight (BW) were measured in offsprings after birth. We stratified the pregnant women into six groups (a) vitamin B12 normal and folic acid normal (BNFN)-control group, (b) vitamin B12 normal and folic acid elevated (BNFE), (c) vitamin B12 normal and folic acid deficient (BNFD), (d) vitamin B12 deficient and folic acid normal (BDFN), (e) vitamin B12 deficient and folic acid elevated (BDFE) and (f) vitamin B12 deficient and folic acid deficient (BDFD) based on their levels of RBC folate (MRF) and vitamin B12 (MB12). The expression of the one-carbon metabolism genes (methionine synthase (MS), glycine N-methyltransferase (GNMT), and cystathionine β-synthase (CBS) was also studied in placental tissue by using real-time PCR. Results: Cord blood RBC folate was significantly reduced in groups BDFE and BDFD as compared to the control group (BNFN). The cord blood vitamin B12 levels were also reduced in the BDFE group as compared to the BDFD. All the newborn parameters viz. PW, HC, CC, and BW, were reduced in the altered MRF/MB12 ratio (low & high vs. normal ratio). Total HCY was significantly elevated in the groups with (BDFE & BDFN) an imbalance of maternal RBC folate and serum vitamin B12 as compared to the control group. Downregulation of one-carbon metabolism genes like MS ( p < 0.001), GNMT ( p < 0.05), and CBS ( p < 0.01) in placental tissue was observed in the high MRF/MB12 ratio group as compared to the normal ratio group. A strong positive correlation was also observed between MRF, MB12, and newborn parameters. Conclusions: The altered ratio of folate to vitamin B12 in the maternal blood is associated with adverse growth and development of the newborn. |
| فهرسة مساهمة: | Keywords: Birth weight; Folic acid; Homocysteine; Placental genes; Pregnancy; Vitamin B12 |
| المشرفين على المادة: | P6YC3EG204 (Vitamin B 12) 935E97BOY8 (Folic Acid) 0LVT1QZ0BA (Homocysteine) |
| تواريخ الأحداث: | Date Created: 20240130 Date Completed: 20240624 Latest Revision: 20240624 |
| رمز التحديث: | 20240625 |
| DOI: | 10.1080/27697061.2024.2307980 |
| PMID: | 38289269 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 2769-707X |
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| DOI: | 10.1080/27697061.2024.2307980 |