دورية أكاديمية
Design of a generic model based on physiology for persistent organic pollutants in laying hens: Applications on chlordecone and chlorinated paraffins.
| العنوان: | Design of a generic model based on physiology for persistent organic pollutants in laying hens: Applications on chlordecone and chlorinated paraffins. |
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| المؤلفون: | Joachim T; Université de Lorraine, INRAE, URAFPA, F-54000 Nancy., Cyril F; Université de Lorraine, INRAE, URAFPA, F-54000 Nancy., Ronan C; ONIRIS, INRAE, LABERCA, 44300 Nantes, France., Gaud D; ONIRIS, INRAE, LABERCA, 44300 Nantes, France., Agnès F; Université de Lorraine, INRAE, URAFPA, F-54000 Nancy. Electronic address: agnes.fournier@univ-lorraine.fr. |
| المصدر: | The Science of the total environment [Sci Total Environ] 2024 Mar 20; Vol. 917, pp. 170447. Date of Electronic Publication: 2024 Jan 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0330500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1026 (Electronic) Linking ISSN: 00489697 NLM ISO Abbreviation: Sci Total Environ Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier. |
| مواضيع طبية MeSH: | Chlordecone*/metabolism , Insecticides*/analysis , Soil Pollutants*/analysis , Hydrocarbons, Chlorinated*, Animals ; Female ; Persistent Organic Pollutants ; Paraffin ; Chickens/metabolism |
| مستخلص: | A Physiology Based Pharmacokinetic (PBPK) model has been developed to predict the kinetics of Persistent Organic Pollutants (POPs) in laying hens. Different datasets have enabled the calibration of the model for chlordecone (CLD), an organochlorine pesticide used in the French West Indies between 1972 and 1993, as well as for chlorinated paraffins (CPs), widely used for various industrial applications worldwide. For this purpose, the sensitivity analysis showed that intake parameters, laying rate, partition coefficients of yolk, hepatic clearance, percentage of metabolism and age were key parameters. Applied to CLD and CPs, this model shows a good capacity for prediction, with 88 % of the experimental values ranging within 1.5-fold of the predicted value at steady state for CPs and 100 % for CLD. The fine modelling of the physiology and the laying process contributes to precision of the model and gives genericity, enabling the switch from one bird species to another. The model can be implemented with other POPs if the clearance and partition coefficient are known. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Animal products; Eggs; Meat; PBPK; POPs; Risk assessment |
| المشرفين على المادة: | RG5XJ88UDF (Chlordecone) 0 (Insecticides) 0 (Persistent Organic Pollutants) 8002-74-2 (Paraffin) 0 (Soil Pollutants) 0 (Hydrocarbons, Chlorinated) |
| تواريخ الأحداث: | Date Created: 20240130 Date Completed: 20240222 Latest Revision: 20240222 |
| رمز التحديث: | 20240222 |
| DOI: | 10.1016/j.scitotenv.2024.170447 |
| PMID: | 38290669 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1026 |
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| DOI: | 10.1016/j.scitotenv.2024.170447 |