دورية أكاديمية
أعرض في EDS

Environmentally benign liquid chromatographic method for concurrent estimation of four antihistaminic drugs applying factorial design approach.

التفاصيل البيبلوغرافية
العنوان: Environmentally benign liquid chromatographic method for concurrent estimation of four antihistaminic drugs applying factorial design approach.
المؤلفون: Ghonim R; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. rana.ghonim@deltauniv.edu.eg.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, International Coastal Road, Gamasa, 11152, Egypt. rana.ghonim@deltauniv.edu.eg., Tolba MM; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., Ibrahim F; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., El-Awady MI; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, International Coastal Road, Gamasa, 11152, Egypt.
المصدر: BMC chemistry [BMC Chem] 2024 Jan 30; Vol. 18 (1), pp. 26. Date of Electronic Publication: 2024 Jan 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Nature Country of Publication: Switzerland NLM ID: 101741142 Publication Model: Electronic Cited Medium: Internet ISSN: 2661-801X (Electronic) Linking ISSN: 2661801X NLM ISO Abbreviation: BMC Chem Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cham, Switzerland : Springer Nature, [2019]-
مستخلص: In the last few decades, green analytical chemistry (GAC) has become a smart magical solution for the qualification and quantification of many drugs. In the current study, a direct, sensitive, and green RP-HPLC method was used to separate three anti-histaminic combinations rupatadine/montelukast, desloratadine/montelukast, fexofenadine/montelukast, and finally a mixture of rupatadine and its metabolite; desloratadine in less than 20 min. The developed method was optimized by a 2 3 full factorial design to improve the chromatographic responses. The proposed method was used to analyze these antihistaminic combinations at different pharmaceutical ratios. The linearity range is from 1 to 10 µg/mL for rupatadine, desloratadine, and montelukast, while for fexofenadine from 1 to 24 µg/mL drugs. The proposed method is useful in common quality control analysis of the investigated quaternary combinations because of its non-toxic and eco-friendly effects on the environment and human beings. The proposed procedure was thoroughly validated in accordance with ICH guidelines and was revealed to be accurate, reproducible, and selective. The developed methods were compared with a reported reference comparison method, where no significant difference was observed.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Desloratadine; Fexofenadine; Green RP-HPLC-factorial design; Montelukast; Rupatadine
تواريخ الأحداث: Date Created: 20240130 Latest Revision: 20240202
رمز التحديث: 20240202
مُعرف محوري في PubMed: PMC10829218
DOI: 10.1186/s13065-024-01117-2
PMID: 38291482
قاعدة البيانات: MEDLINE
الوصف
تدمد:2661-801X
DOI:10.1186/s13065-024-01117-2