دورية أكاديمية
أعرض في EDS

Efficacy of topical gabapentin in women with primary macular amyloidosis: A side-by-side triple-blinded randomized clinical trial.

التفاصيل البيبلوغرافية
العنوان: Efficacy of topical gabapentin in women with primary macular amyloidosis: A side-by-side triple-blinded randomized clinical trial.
المؤلفون: Abtahi-Naeini B; Pediatric Dermatology Division of Department of Pediatrics, Imam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Hemati E; Pediatric Dermatology Division of Department of Pediatrics, Imam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran., Faghihi G; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Shahmoradi Z; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Paknazar F; Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran., Rastegarnasab F; Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran., Varshosaz J; Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Hadian M; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Akbari M; Department of Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran., Sabzghabaee AM; Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
المصدر: Journal of cosmetic dermatology [J Cosmet Dermatol] 2024 May; Vol. 23 (5), pp. 1677-1684. Date of Electronic Publication: 2024 Jan 30.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: Blackwell Science Country of Publication: England NLM ID: 101130964 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2165 (Electronic) Linking ISSN: 14732130 NLM ISO Abbreviation: J Cosmet Dermatol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, UK : Blackwell Science, c2002-
مواضيع طبية MeSH: Gabapentin*/administration & dosage , Pruritus*/drug therapy , Pruritus*/etiology , Amyloidosis, Familial*, Humans ; Female ; Middle Aged ; Treatment Outcome ; Amyloidosis/drug therapy ; Amyloidosis/complications ; Adult ; Skin Diseases, Genetic/drug therapy ; Aged ; Skin Cream/administration & dosage ; Administration, Cutaneous ; Double-Blind Method
مستخلص: Background: Primary cutaneous macular amyloidosis (PCMA) is a chronic pruritic cutaneous disease characterized by heterogeneous extracellular deposition of amyloid protein in the skin.
Aims: This study aimed to evaluate the efficacy of topical 6% gabapentin cream for the treatment of patients with PCMA.
Materials and Methods: In this triple-blind clinical trial, a total of 34 patients, who were diagnosed with PCMA, treated using two different strategies of topical gabapentin as the active group and vehicle cream as the control group.
Results: Pruritus score reduction in both groups was statistically significant compared with the baseline value (p < 0.001). There was a significant pigmentation score reduction in intervention group compared with control group after 1 month of the study (p < 0.001). The differences of pigmentation score changes between the groups were not significant at month 2 (p = 0.52) and month 3 (p = 0.22).
Conclusions: The results of this study suggest that topical gabapentin cream may be effective as a topical agent in the treatment of pruritus associated with PCMA without any significant adverse effects. It is recommended to perform similar studies with a larger sample size and longer duration in both sexes.
(© 2024 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: gabapentin; macular amyloidosis; pruritus; topical gabapentin
المشرفين على المادة: 6CW7F3G59X (Gabapentin)
SCR Disease Name: Amyloidosis, Primary Cutaneous
تواريخ الأحداث: Date Created: 20240131 Date Completed: 20240424 Latest Revision: 20240502
رمز التحديث: 20240503
DOI: 10.1111/jocd.16180
PMID: 38291677
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-2165
DOI:10.1111/jocd.16180