دورية أكاديمية
Onabotulinum Toxin A (BoNT-A) for Drooling in Children: A Systematic Review and Meta-Analysis.
| العنوان: | Onabotulinum Toxin A (BoNT-A) for Drooling in Children: A Systematic Review and Meta-Analysis. |
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| المؤلفون: | Oad H; Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Quebec, Canada., Maltezeanu A; Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Quebec, Canada., da Silva SD; Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Quebec, Canada., Daniel SJ; Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Quebec, Canada. |
| المصدر: | The Laryngoscope [Laryngoscope] 2024 Jul; Vol. 134 (7), pp. 3012-3017. Date of Electronic Publication: 2024 Jan 31. |
| نوع المنشور: | Systematic Review; Journal Article; Meta-Analysis; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8607378 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-4995 (Electronic) Linking ISSN: 0023852X NLM ISO Abbreviation: Laryngoscope Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2009- >: Philadelphia, PA : Wiley-Blackwell Original Publication: St. Louis, Mo. : [s.n., 1896- |
| مواضيع طبية MeSH: | Sialorrhea*/drug therapy , Sialorrhea*/etiology , Botulinum Toxins, Type A*/administration & dosage , Botulinum Toxins, Type A*/therapeutic use, Humans ; Child ; Neuromuscular Agents/administration & dosage ; Neuromuscular Agents/therapeutic use ; Neuromuscular Agents/adverse effects ; Treatment Outcome ; Child, Preschool ; Adolescent ; Male ; Female |
| مستخلص: | Introduction: Sialorrhea, also known as drooling, hypersalivation, or ptyalism, has a significant impact on the medical and psychosocial well-being of children. Onabotulinum toxin A (BoNT-A) is the most commonly used botulinum toxin worldwide for the treatment of sialorrhea in children. Objectives: To conduct a comprehensive systematic review and meta-analysis to assess the clinical efficacy and potential adverse effects of BoNT-A as a treatment for drooling in children. Methods: Cochrane, Embase, and Medline databases were systematically searched (up to May 2023). Out of 535 identified publications, 20 were found eligible for inclusion. A systematic review and meta-analysis were performed to determine the efficacy of BoNT-A treatment in children in reducing the frequency and severity of drooling. Results: Out of the 20 studies included, a meta-analysis was conducted on the complete dataset of eight studies involving 131 patients. BoNT-A was found to significantly decrease the severity of drooling in patients with sialorrhea (standardized mean difference [SMD], -2.07; 95% confidence interval [CI], -2.91 to -1.23; p < 0.0001) when compared with the conditions before injections using random-effects models. Six studies out of 20 reported dysphagia as an adverse effect after injection. Other side effects included thickness of saliva and pain at the site of injection. Conclusion: BoNT-A is a clinically effective therapy that improves drooling severity in children with sialorrhea. Although there were some adverse side effects reported, they were transient and not severe. Future studies are needed to further evaluate the best techniques and to identify the ideal dosages required to achieve the optimal outcomes. Laryngoscope, 134:3012-3017, 2024. (© 2024 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.) |
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| فهرسة مساهمة: | Keywords: BoNT‐A; botulinum neurotoxin‐A; children; drooling; sialorrhea |
| المشرفين على المادة: | EC 3.4.24.69 (Botulinum Toxins, Type A) EC 3.4.24.69 (onabotulinum toxin A) 0 (Neuromuscular Agents) |
| تواريخ الأحداث: | Date Created: 20240131 Date Completed: 20240617 Latest Revision: 20240624 |
| رمز التحديث: | 20240624 |
| DOI: | 10.1002/lary.31277 |
| PMID: | 38294288 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1531-4995 |
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| DOI: | 10.1002/lary.31277 |