دورية أكاديمية
Efficacy of bronchial thermoplasty in a patient panel with uncontrolled severe persistent asthma.
| العنوان: | Efficacy of bronchial thermoplasty in a patient panel with uncontrolled severe persistent asthma. |
|---|---|
| المؤلفون: | Zikos A; Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, PA, USA., Balaan M; Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, PA, USA., Hobart E; Care Analytics Department, Highmark Health, Pittsburgh, PA, USA., Bansal S; Department of Internal Medicine, The Lung Center, Penn Highlands Healthcare, Dubois, PA, USA., Saeed R; Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, PA, USA., Cheema T; Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, PA, USA., Gentile D; Department of Health Science, Saint Francis University, Loretto, PA, USA. |
| المصدر: | The Journal of asthma : official journal of the Association for the Care of Asthma [J Asthma] 2024 Aug; Vol. 61 (8), pp. 867-875. Date of Electronic Publication: 2024 Feb 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8106454 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-4303 (Electronic) Linking ISSN: 02770903 NLM ISO Abbreviation: J Asthma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: [Ossining, N.Y. : Asthma Publications Society, c1981- |
| مواضيع طبية MeSH: | Asthma*/therapy , Asthma*/surgery , Bronchial Thermoplasty*/methods , Quality of Life*, Humans ; Female ; Male ; Adult ; Middle Aged ; Prospective Studies ; Treatment Outcome ; Severity of Illness Index ; Nitric Oxide/analysis ; Nitric Oxide/metabolism ; Spirometry ; Peak Expiratory Flow Rate |
| مستخلص: | Background: Bronchial thermoplasty (BT) is an approved procedure to manage uncontrolled severe persistent asthma. Many insurance providers are reluctant to pay for BT without proven benefit among their specific patient panel. Objective: Determine if BT is effective in a panel patient panel with uncontrolled severe persistent asthma. Study Design and Methods: This was an unblinded prospective study of adult subjects with uncontrolled severe persistent asthma who underwent BT. Outcomes were assessed at baseline and then 3-, 6-, 12-, 18- and 24-months post-BT. The primary metric was an improved Asthma Quality of Life Questionnaire (AQLQ) score. Other metrics included improved Asthma Control Test (ACT), peak expiratory flow rates (PEFR), spirometry, fractional excretion of nitric oxide (FeNO), number of unscheduled medical visits, and lost days of work/activity. Respiratory adverse events were assessed during the BT treatment period and at each post-BT visit. Results: Twenty-nine subjects completed the study; the median interquartile range (IQR) age was 47 (42-61), and the majority were female (69%), white (93%), and non-Hispanic (90%). After BT, mean (±std) AQLQ scores improved by 1.6(±1.1) at 3 months ( p < 0.0001), 1.6(±1.2) at 6 months ( p < 0.0001), 1.4(±1.0) at 12 months ( p < 0.0001), 1.8(±1.1) at 18 months ( p < 0.0001), and 1.6 (±1.5) at 24 months ( p < 0.0001). There were significant improvements in ACT, PEFR, unscheduled medical visits and lost days of work and activity. Spirometry and FeNO metrics were unchanged. The average cost for subjects completing all 3 BT procedures was approximately $15,000. Conclusion: BT is an effective adjunctive therapeutic modality in subjects with uncontrolled severe persistent asthma. |
| فهرسة مساهمة: | Keywords: Quality of life; efficacy; medical costs; safety; treatment |
| المشرفين على المادة: | 31C4KY9ESH (Nitric Oxide) |
| تواريخ الأحداث: | Date Created: 20240131 Date Completed: 20240705 Latest Revision: 20240705 |
| رمز التحديث: | 20240705 |
| DOI: | 10.1080/02770903.2024.2309532 |
| PMID: | 38294702 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1532-4303 |
|---|---|
| DOI: | 10.1080/02770903.2024.2309532 |