دورية أكاديمية
Neuroprotective effect of gallic acid in mice with rotenone-induced neurodegeneration.
| العنوان: | Neuroprotective effect of gallic acid in mice with rotenone-induced neurodegeneration. |
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| المؤلفون: | Thong-Asa W; Animal Toxicology and Physiology Specialty Research Unit (ATPSRU), Department of Zoology, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Jatujak, Bangkok 10900, Thailand., Wassana C; Animal Toxicology and Physiology Specialty Research Unit (ATPSRU), Department of Zoology, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Jatujak, Bangkok 10900, Thailand., Sukkasem K; Animal Toxicology and Physiology Specialty Research Unit (ATPSRU), Department of Zoology, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Jatujak, Bangkok 10900, Thailand., Innoi P; Animal Toxicology and Physiology Specialty Research Unit (ATPSRU), Department of Zoology, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Jatujak, Bangkok 10900, Thailand., Dechakul M; Animal Toxicology and Physiology Specialty Research Unit (ATPSRU), Department of Zoology, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Jatujak, Bangkok 10900, Thailand., Timda P; Animal Toxicology and Physiology Specialty Research Unit (ATPSRU), Department of Zoology, Faculty of Science, Kasetsart University, 50 Ngam Wong Wan Road, Jatujak, Bangkok 10900, Thailand. |
| المصدر: | Experimental animals [Exp Anim] 2024 Jul 09; Vol. 73 (3), pp. 259-269. Date of Electronic Publication: 2024 Feb 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Japanese Association for Laboratory Animal Science Country of Publication: Japan NLM ID: 9604830 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-7122 (Electronic) Linking ISSN: 00075124 NLM ISO Abbreviation: Exp Anim Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo : Japanese Association for Laboratory Animal Science |
| مواضيع طبية MeSH: | Rotenone* , Gallic Acid*/pharmacology , Gallic Acid*/administration & dosage , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/administration & dosage, Animals ; Male ; Mice, Inbred ICR ; Corpus Striatum/metabolism ; Corpus Striatum/drug effects ; Mice ; Oxidative Stress/drug effects ; Neurodegenerative Diseases/chemically induced ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/prevention & control ; Lipid Peroxidation/drug effects ; Tyrosine 3-Monooxygenase/metabolism |
| مستخلص: | We investigated the effect of gallic acid (Gal) against neurodegenerative pathophysiology relevant to Parkinsion's disease (PD) in mice with rotenone-induced toxicity. Forty male institute of cancer research (ICR) mice were randomly divided into four groups: sham-veh, PD-veh (received subcutaneous injection with 2.5 mg/kg/48 h of rotenone); PD-Gal50; and PD-Gal100 (the latter two groups received subcutaneous injection with 2.5 mg/kg/48 h of rotenone and oral gavage with gallic acid 50 and 100 mg/kg/48 h, respectively). All treatments continued for 5 weeks with motor ability assessments once per week using hanging and rotarod tests. Brain tissue evaluation of oxidative status, together with striatal and substantia nigra par compacta (SNc) histological and immunohistological assessments were performed. The results indicate that rotenone significantly induced muscle weakness and motor coordination deficit from the first week of rotenone injection, and a significant increase in neuronal degeneration was presented in both the striatum and SNc. Decreased tyrosine hydroxylase and increment of glia fibrillary acidic protein expression in SNc were depicted. The deteriorating effects of rotenone were ameliorated by gallic acid treatment, especially 100 mg/kg dose. Rotenone did not induce a significant change of lipid peroxidation indicated, but gallic acid exhibited a significant inhibitory effect on the lipid peroxidation increment. Rotenone showed a significant reduction of superoxide dismutase activity, and neither 50 nor 100 mg/kg of gallic acid could alleviate this enzyme activity. In conclusion, gallic acid ameliorated motor deficits and preserving SNc neurons which led to maintaining of the dopaminergic source, including a nurturing effect on supporting astrocytes in mice with rotenone-induced neurodegeneration. |
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| فهرسة مساهمة: | Keywords: Parkinson’s disease; gallic acid; rotenone; striatum; substantia nigra |
| المشرفين على المادة: | 03L9OT429T (Rotenone) 632XD903SP (Gallic Acid) 0 (Neuroprotective Agents) EC 1.14.16.2 (Tyrosine 3-Monooxygenase) |
| تواريخ الأحداث: | Date Created: 20240131 Date Completed: 20240710 Latest Revision: 20240719 |
| رمز التحديث: | 20240719 |
| مُعرف محوري في PubMed: | PMC11254496 |
| DOI: | 10.1538/expanim.23-0165 |
| PMID: | 38296489 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1881-7122 |
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| DOI: | 10.1538/expanim.23-0165 |