Near-Infrared Fluorescent Silica Nanoparticles Based on Gold-Silver Alloy Nanoclusters for Clinical Diagnosis.

التفاصيل البيبلوغرافية
العنوان:	Near-Infrared Fluorescent Silica Nanoparticles Based on Gold-Silver Alloy Nanoclusters for Clinical Diagnosis.
المؤلفون:	Ichimaru H; Tsukuba Research Laboratories, Tokuyama Corporation., Kikuchi S; Tsukuba Research Laboratories, Tokuyama Corporation.
المصدر:	Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2024; Vol. 72 (1), pp. 121-126.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Pharmaceutical Society of Japan Country of Publication: Japan NLM ID: 0377775 Publication Model: Print Cited Medium: Internet ISSN: 1347-5223 (Electronic) Linking ISSN: 00092363 NLM ISO Abbreviation: Chem Pharm Bull (Tokyo) Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Tokyo, Pharmaceutical Society of Japan.
مواضيع طبية MeSH:	Gold Alloys* , Metal Nanoparticles*, Animals ; Horses ; Silver ; Silicon Dioxide ; Gold
مستخلص:	In clinical diagnosis, fluorescent particles are applied to detect analytes in biofluids, such as blood and saliva. However, current fluorescence detection methods have not been optimized to account for the overlapping autofluorescence peaks of biological substances. Gold and silver nanoclusters are known to the novel fluorescent materials and their emission wavelengths depend on cluster size. In this study, we developed fluorescent silica nanoparticles using gold-silver alloy nanoclusters and chitosan (CS) (NH 2 -SiO 2 @Au@CS@AuAg) by the layer-by-layer method. Under UV-light irradiation at 365 nm, the emission wavelength of NH 2 -SiO 2 @Au@CS@AuAg reached 750 nm in the near-IR region. Scanning electron microscopy images revealed that the shape of NH 2 -SiO 2 @Au@CS@AuAg was uniform and spherical. The fluorescence spectrum of horse blood obtained in the presence of NH 2 -SiO 2 @Au@CS@AuAg contained a specific fluorescence peak attributed to NH 2 -SiO 2 @Au@CS@AuAg, which was distinguishable from the autofluorescence peaks. These results showed that NH 2 -SiO 2 @Au@CS@AuAg has advantageous fluorescence properties for clinical diagnostic applications.
فهرسة مساهمة:	Keywords: clinical diagnosis; fluorescent silica nanoparticle; gold–silver alloy nanocluster; layer-by-layer method; near-IR emission
المشرفين على المادة:	0 (Gold Alloys) 3M4G523W1G (Silver) 7631-86-9 (Silicon Dioxide) 7440-57-5 (Gold)
تواريخ الأحداث:	Date Created: 20240131 Date Completed: 20240214 Latest Revision: 20240214
رمز التحديث:	20240214
DOI:	10.1248/cpb.c23-00688
PMID:	38296514
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1347-5223
DOI:	10.1248/cpb.c23-00688