التفاصيل البيبلوغرافية
| العنوان: |
Association Between Atherogenic Index of Plasma and Risk of Incident Major Adverse Cardiovascular Events. |
| المؤلفون: |
Zhi YW; Department of Intensive Care Unit, Sun Yat-sen Memorial Hospital, Sun Yat-sen University., Chen RG; Department of Intensive Care Unit, Hospital of Changan Dongguan., Zhao JW; Comprehensive Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University., Zhou SX; Cardiovascular Center, Hospital of Changan Dongguan., He ZJ; Department of Intensive Care Unit, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. |
| المصدر: |
International heart journal [Int Heart J] 2024; Vol. 65 (1), pp. 39-46. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: International Heart Journal Association Country of Publication: Japan NLM ID: 101244240 Publication Model: Print Cited Medium: Internet ISSN: 1349-3299 (Electronic) Linking ISSN: 13492365 NLM ISO Abbreviation: Int Heart J Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: [Tokyo, Japan] : International Heart Journal Association, [2005]- |
| مواضيع طبية MeSH: |
Atherosclerosis* , Hypertension* , Diabetes Mellitus*/epidemiology, Humans ; Male ; Female ; Middle Aged ; Triglycerides ; Risk Factors |
| مستخلص: |
It is unclear whether the atherogenic index of plasma (AIP) is associated with major adverse cardiovascular events (MACEs) in the general population. A total of 361,644 participants (aged 56.19 ± 8.09 years; 44.79% male) free of a history of MACEs at baseline from the UK Biobank data were included in the analysis. The AIP was calculated using log (triglyceride/high-density lipoprotein-cholesterol). Over a mean follow-up of 12.19 ± 1.60 years, 16,683 participants developed MACEs. After adjustment for traditional risk factors, each 1 unit increase in AIP was associated with a 45.3% higher risk of incident MACEs (hazard ratio (HR), 1.453 [95% confidence interval (CI) 1.371-1.540], P < 0.001). Results were similar when individuals were categorized by the AIP quartiles (HR, 1.283 [95% CI 1.217-1.351]; comparing extreme quartiles). The subgroup analyses showed that the association between AIP and risk of incident MACEs was more obvious in female participants who are < 60 years old and free of hypertension or diabetes. Sensitivity analysis included participants without any lipid-lowering medication or excluded incident MACEs in the first 2 years of follow-up confirming the robustness of the findings. Elevated AIP is a risk factor of incident MACEs in the general population, independent of traditional risk factors.Dynamic monitoring of the AIP may help select the population at high risk of cardiovascular events and guide primary prevention. |
| فهرسة مساهمة: |
Keywords: Cardiovascular disease; General population; Lipids; Prevention; Risk factors |
| المشرفين على المادة: |
0 (Triglycerides) |
| تواريخ الأحداث: |
Date Created: 20240131 Date Completed: 20240214 Latest Revision: 20240214 |
| رمز التحديث: |
20240214 |
| DOI: |
10.1536/ihj.23-406 |
| PMID: |
38296577 |
| قاعدة البيانات: |
MEDLINE |
